Pablo Angeles Tacchino

Next up Zigakibart in IgAN treated for 76 weeks.

Zigakibart is an April inhibitor (learned how to access the poster slides, so screen grabs rather than photos of the slides)

Title, methods, and table 1 demographics #GlomCon

Lionel MEST-C

I'm dying
#GlomCon #Edgar1ofAKind

It wouldn't be an @edgarvlermamd.bsky.social lecture without a Spiderman ref #GlomCon

Fervenza has been asked about galactose deficient IgA1. He says he is going to be nice but then says he has nothing nice to say about KDIGO.

He says guidelines are always backward looking. No answer about Gd-IgA1 though

#GlomCon

👩🏻 75-year-old woman
- History of epilepsy
📈 Creatinine: 2.36 → 7.3 mg/dL in 9 days
🧪 Positive MPO ANCA (61.06)

After 8 years, a new AHA/ACCA hypertension guideline

📊 Proposes cardiovascular risk assessment using the PREVENT calculator.

Urine albumin-to-creatinine ratio in all hypertensive patients.

Plasma aldosterone-to-renin ratio to detect hyperaldosteronism.

HDF over HD: New report from the EuDial working group
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social

High or Low Phosphate? Are we Missing the (P)oint? — NephJC This week, we will discuss the phosphate targets in dialysis. Are you aiming for HIgh or Low?

HiLo, HiLo it's off to work we go! ⛏️
Join us 9 pm EST 8/5/25 to discuss. #NephJC #NephSky
Controlling Phos in patients on HD is a lot of work, but is it worth it? HiLo looks at hospitalization & death in low/high Phos goals. Will we finally have a RCT with answers ⁉️
www.nephjc.com/news/hilo-tr...

so the HiLo study was unremarkable in the treatmet of Hyperphosphahtemia, will the Phosphate trial tell us something different?

The Pathology Lesion Patterns of Podocytopathies: How and why?
#ERA25 🇦🇹 #Nephpearls #NephSky

👉 pubmed.ncbi.nlm.nih.gov/35281116/

Adverse effects

Hyperkalemia rates not lower with adding a flozin to the MRA 🤔

www.nejm.org/doi/full/10....

#ERA25

Urinary Albumin-to-Creatinine Ratio, Serum Potassium Level, Estimated Glomerular Filtration Rate, and Systolic Blood Pressure over Time.

The first #ERA25 simultaneous pub

CONFIDENCE trial of empagliflozin + finerenone in N = 579

Greater reduction in ACR and BP
Note the impressive GFR dip

www.nejm.org/doi/full/10....

Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes | NEJM Limited evidence exists to support the simultaneous initiation of sodium–glucose cotransporter-2 inhibitors and finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in persons with chr...

www.nejm.org/doi/full/10....
Very exciting to hear about this ground breaking clinical trial at #era2025

#era25 following through social media expectorante the resultado of CONFIDENCE trial.

In Heart Failure, Finerenone 20-40mg vs placebo, ↓ cardiorenal risks, effect appears to be independient of the renal risk, ↓ albuminuria more Benefit in renal outcome

PostHoc of FINEARTS-HF
JACC 2025. doi.org/10.1016/j.jc...

Different guidelines hypertension targets comparisson. HYPERTENSION 2025. #Hypertension

So maybe we don’t need to hold flozins before surgery after all?

jamanetwork.com/journals/jam...

📢 New CREDENCE data in NDT:

SGLT2i in CKD and T2D:
✅ ↓ Insulin initiation/dose intensification by 19%
✅ ↑ Reductions in insulin dose by up to 49%
✅ Consistent ↓ in insulin use down to GFR of 30ml/min in whom glycosuric effect is minimal

academic.oup.com/ndt/advance-...

Cool picture . cats claw is quite popular in Peru. #Nephmadness 2025

Spicy!

Adding lasix to the management of hepatorenal syndrome might be ok if you bump the MAP with pressors

@juancarlosqvelez.bsky.social

doi.org/10.1016/j.ek...
#nephsky #liversky

#NephMadness 2025: The PodCrawl Submit your picks! |  @NephMadness |@nephmadness.bsky.social | NephMadness 2025 Over the next couple of weeks, NephMadness 2025 will be popping up on some great podcasts.  Keep your eyes and ears o…

#NephMadness 2025: The PodCrawl

buff.ly/p3xR3cg

Podcasts:
- @thecurbsiders.bsky.social
- Life as a Nephrology Professional @nkf-professionals.bsky.social
- GN in Ten
- @rheummadness.bsky.social
- @freelyfiltered.bsky.social
- Poison Lab
- Nephron Segment
- Kidney Chronicles

Interesante

Acute Kidney Injury Associated with Novel Anti-Cancer... : Kidney360 ertain extent by systemic inflammatory toxicities affecting directly or indirectly the kidney. In the case of ICIs severe acute interstitial nephritis is the main adverse event and can lead to permane...

journals.lww.com/kidney360/ab.... Great paper review Kidney 360

🤔🤔Ever heard of DMANDs-Disease modifying anti nephropathic drugs

doi.org/10.1093/ndt/...

@hjanders.bsky.social #Nephsky
#Nephpearls

✅Why is it Class 1A-1E and not class 1-5 in MIC (Mayo imaging classification)?
✅That’s because Class 1️⃣ is Typical ADPKD and Class 2️⃣ is atypical ADPKD.
✅Checkout what’s typical and atypical ADPKD 👇
✅However, note that the predictive tool is valid for typical category only 🤔

YouTube video by NEJM Group Liraglutide for Children with Obesity | NEJM

Lifestyle interventions are the cornerstone of treatment for children with obesity, but additional treatments, such as medications, may be needed. Research findings on liraglutide in children with obesity are summarized in a Quick Take video. youtu.be/bvxWTUGVeww

#MedSky #PedSky