Sara Wickstrom

#CABDseminars

"Mechanical regulation of cell states" by Sara Wickström @sarawickstrom.bsky.social, @mpi-muenster.bsky.social

🗓️October 10th
⏰ 12 pm
📍Rosalind Franklin auditorium, CABD

Co-hosted by @dariloops.bsky.social & @jrmarmor.bsky.social

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

Pathway to Independence: a forecast for the future of developmental biology ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Thank you Leo!

Thank you Elias!

Thank you for highlighting our paper Daryl! We are very proud of this one too 😊

Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture - Nature Cell Biology Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.

Third paper to highlight!
Here, Lisa Manning, @sarawickstrom.bsky.social, &c olleagues show contractility, pressure, signalling cooperating in vertebrate development, w/thorough combination of expertise in cell biology, signalling, & biophysics.

(Open Access) www.nature.com/articles/s41...

Thank you Jorge! Nice discussions today 😊

Promotional graphic for a special issue of Journal of Cell Science titled 'Cell Biology of the Nucleus.' Guest Editor: Abby Buchwalter. Submission deadline: 3 November 2025. The image features a stylized cell with a bright pink, heart-shaped nucleus on a black background. Text includes a call for papers.

We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...

#cellbiology #nucleus #notforprofit #freetopublish

Thank you Christian!

Thank you Carmelo!

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Nice work from the labs of @katemiro.bsky.social @sarawickstrom.bsky.social
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

www.nature.com/articles/s41...

Thank you Adrien!

A landmark study by @sarawickstrom.bsky.social @katemiro.bsky.social and colleagues elucidating the relative contribution of GF and nuclear mechanics on cell fate decisions🤩 !! Many congratulations on this 'tour de force' 👏🎉 (pun on words intended 😉!) !!

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

Thank you Francesca!

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Thanks so much Alejo!

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

Contractile fibroblasts form a transient niche for the branching mammary epithelium Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Thank you Andre! Looking forward to hearing what you think 🤓

Amazing to have our work finally out!!! 😍🤩😍

Indeed! Excited to be discussing this work at CellMech!

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Thank you Joaquin ❤️

😂 that paper has been on my mind while working on this 😅

Thank you Manuel! Indeed I think this is quite similar in many ways in terms of the role of cytoskeletal confinement!

a group of power rangers standing next to each other with the words `` super team '' above them . ALT: a group of power rangers standing next to each other with the words `` super team '' above them .

(8/8)This was an exciting but challenging project with amazing teamwork from @akistubb.bsky.social @mccreery.bsky.social @katemiro.bsky.social lab 🙏 fantastic collaborators and support @mpi-muenster.bsky.social @stemmprogram.bsky.social @helsinki.fi