Celeste Karch

🎉🎉🎉🎉🎉🎉🎉

Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org/news/2025/ke...

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

Could blocking ‘jumping genes’ help fight disease and aging? The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!

Registration 🔗 us02web.zoom.us/meeting/regi...

#NewVisionResearch #ProfessionalDevelopment

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting. Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration

A neuroimmune circuit mediates cancer cachexia-associated apathy Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

March 19 Participant Toolkit | NEA On Wednesday, March 19, our communities will walk into our schools together to show elected leaders that we are united in support for the programs and protections our communities need to thrive.

When educators, students, families, and community members come together, there is nothing we cannot achieve. Join us to protect students and families on March 19 by attending or hosting a “walk-in” at your local school: nea.org/March19

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders - Molecular Neurodegeneration Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood gli...

NfL beats GFAP in a head-to-head FTD biomarker competition. Gendron et al. show plasma GFAP and NfL correlate with FTD disorder severity; however, NfL outperforms GFAP as a prognostic biomarker and potential susceptibility marker.

molecularneurodegeneration.biomedcentral.com/articles/10....

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration
www.nature.com/articles/s41...

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies - Molecular Neurodegeneration Background Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the mec...

Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....

🤩Preprint alert👇 Excited to introduce the concept of transformative neuropathology, a term we use to describe the integration of foundational descriptive pathology with advanced technologies and methodologies 🔬🏛️🧬🧪🖥️🔬 🧠📊🤖
@cshlnews.bsky.social

www.preprints.org/manuscript/2...

A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD) npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

Results from our AntiRetroviral Therapy for Alzheimer's Disease (ART-AD) clinical trial are available online today and will be included in the inaugural issue of npj Dementia.

rdcu.be/edfwq

PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD: Neuron www.cell.com/neuron/fullt...

If you are in St Louis this weekend, join MO Jobs with Justice to support federal workers

2025 Brain Prize honors pair of cancer neuroscientists Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.

@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience.

By @sydneywyatt.bsky.social

#neuroskyence

www.thetransmitter.org/community/20...

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social

www.nature.com/articles/s41...

(Collaborative work with Panos Roussos and his team! )

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model - Nature Neuroscience The mechanisms of pathological astrocyte responses during multiple sclerosis remain unclear. Kadowaki et al. found in MS mouse models that CLEC16A suppresses astrocyte pathogenic activities related to...

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model @NatureNeuro
www.nature.com/articles/s41...