@astbury-bsl.bsky.social
#CryoEM #CryoET @universityofleeds.bsky.social Funded access via @instruct-eric.bsky.social Find out more about our training: http://bit.ly/3Szodyw
🚨 Abstract submission extended to Oct 21!
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹
Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!
#OpenSoftwareAcceleratesScience
www.biorxiv.org/content/10.1...
Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!
22.08.2025 21:37 — 👍 30 🔁 10 💬 0 📌 1
🚨 We’re hiring! 🚨
We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL!
You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM).
Any questions? Get in touch!
jobs.leeds.ac.uk/Vacancy.aspx...
Delighted to see our publication with industry partners out! 🎉
Huge shoutout to @jbrwhite.bsky.social and @oksana-degtjarik.bsky.social for their contributions to the structural work!
Many thanks to @chingshinhuang.bsky.social & the whole team for an excellent collaboration!
#CryoEM #drugdiscovery
Structure of human TRPC5 in complex with the plant nature product (-)-englerin A
We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation".
www.biorxiv.org/content/10.1...
🚀 Less than a week left to apply for our ‘Introduction to Single-Particle Cryo-EM 2025’
Course Dates: 1th - 4th September 2025
Application Deadline: 17th July 2025
astbury.leeds.ac.uk/facilities/w...
🚨 Applications now open!
Join us in Leeds for the Wellcome-MRC Cryo-EM Training Course
📅 1–4 Sept 2025 | 🧊 Beginners tailored
🔬 Hands-on single-particle cryo-EM
👉 More info and to apply: forms.office.com/e/QHYmbcsZ33
A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!
02.06.2025 17:32 — 👍 9 🔁 2 💬 0 📌 0Oops—wrong tag earlier! Meant to tag @richjallen.bsky.social Thanks again for the brilliant talk!
20.05.2025 14:11 — 👍 2 🔁 0 💬 0 📌 0
Wonderful #PintOfScience evening with @maddie-gilbert.bsky.social and @richardallenart.bsky.social making sense of memory loss! The memory test results may already have slipped our minds…😅
Huge thanks to our own @c-hawksworth.bsky.social for helping organise such a great event!🍺
Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!
12.05.2025 10:10 — 👍 8 🔁 5 💬 0 📌 0Haha, baby FastBlot comes with a built-in northern narrator? 🤣
08.05.2025 09:21 — 👍 0 🔁 0 💬 0 📌 0
The perfect gift doesn’t exi… Oh wait!
Those tiny replicas of our Titan Krios microscopes are absolutely adorable! 🥹❄️
Thank you so much @snowentific.bsky.social!
Wishing you all the best in your next adventure - you will be missed!
“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
07.05.2025 10:56 — 👍 66 🔁 14 💬 2 📌 2
The full paper here www.nature.com/articles/s41...
25.04.2025 16:40 — 👍 0 🔁 0 💬 0 📌 0
Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
Huge shout out to @jenkinsjj.bsky.social for his excellent talk on the #cryoET structure of Tau filaments from human brain tissue at CCPEM Spring Symposium in Nottingham! #cryo-EM @diamondlightsource.bsky.social @ccpem.bsky.social
24.04.2025 17:31 — 👍 11 🔁 3 💬 1 📌 0It's great to be at the CCPEM conference in Nottingham this week, with talks from many Instruct facilities including @astburycentre.bsky.social, @astbury-bsl.bsky.social, @diamondlightsource.bsky.social, and @ox.ac.uk!
Find out more about the Instruct-UK centre - instruct-eric.org/centres/inst...
Grateful to @wellcometrust.bsky.social for funding 💙
15.04.2025 09:42 — 👍 1 🔁 0 💬 0 📌 0
Another week, another training course wrapped up ✅
Huge thanks to our fantastic participants for sticking with us through the reschedule, and to our amazing lecturers & tutors for making it a success: @leicstructbio.bsky.social @diamondlightsource.bsky.social @uofglasgow.bsky.social
& Birkbeck, UoL
I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.
10.04.2025 13:46 — 👍 37 🔁 10 💬 1 📌 0🔬 Exciting to see our custom time-resolved cryo-EM device featured in Nature!
A groundbreaking look at the swinging lever mechanism of myosin in action!
Huge congrats to @scarfflab.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social and everyone involved!
#cryoEM
#CryoSPARC v4.7 is out! 🚀
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates
#cryoEM
🔬Sibling rivalry alert!
Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡
Exciting times ahead!
Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌
#cryoEM #cryoET
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
A special thank you to our incredible co-organisers from @diamondlightsource.bsky.social @drlornamalone.bsky.social and to @mrclmb.bsky.social & @wellcometrust.bsky.social for making this event possible!
More courses coming soon—follow us for updates! 🚀
🎉 And that’s a wrap!
The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions.
Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM
📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢
📅 Application deadline: 7th April 2025
@astonaime.bsky.social
tinyurl.com/4arujyaw
Really pleased to share this story in collaboration with our fantastic industry partners @chingshinhuang.bsky.social !
20.02.2025 19:04 — 👍 3 🔁 3 💬 0 📌 0
