PombeDoc

Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site - PubMed We analyzed upstream activation sequence 2 (UAS2), one of two independent UAS elements in the CYC1 gene of Saccharomyces cerevisiae. Deletions and linker scanning mutations across the 87 base pairs pr...

Oh and of particular amusement , two posters talking about CCAAT sequence elements and php/pombe HAP transcription factor. My very first paper as a PhD student identified the CCAAT sequence in cerevisiae as a HAP responsive element. A very long time ago.

pubmed.ncbi.nlm.nih.gov/2832731/

I’m at #pombe2025 with the small but mighty international fission yeast community talking about everything from heterochromatin to membrane fusion to lateral gene transfer. This is such a great community. Thanks to @drpombe.bsky.social and colleagues for putting this together!

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

💯

it’s a real testament to the intellectual traditions of these centuries-old institutions, folding to authoritarian pressure like paper in a storm and kneeling to naked financial extortion

Every Scientific Empire Comes to an End America’s run as the premiere techno-superpower may be over.

I hope the voters wanted death, suffering, corruption, and hyperinflation, because that is the logical endpoint.

www.theatlantic.com/science/arch...

Are you a scientist who wants to advocate for federal science funding? 📣

SNAP is helping early-career researchers meet with their representatives while they’re home this August, ahead of the FY2026 budget vote, where major cuts to NIH and NSF are on the table.

No experience needed—Just your voice!

Senator Murray Opening Remarks at Full Committee Mark Up of Defense and Labor, Health and Human Services, and Education Bills | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

Public pressure works. The Senate proposed FY26 funding for the NIH that is being voted on today includes a $400 million increase. Keep up the great work everyone, call your house representatives and make sure this passes through the full Senate.

The Premature Guide to Post-Trump Reform American history offers three general strategies of repair and renewal.

Out today @prospect.org “Trump has shown how vulnerable [we are] … authoritarian rule when the president is contemptuous of [constitutional] norms, Congress is under his thumb, and the Court is an accomplice.” What to do? Here you go: “The Premature Guide to Post-Trump Reform” tinyurl.com/yunb54ab

Trump Administration Scraps Effort to Pause Health-Research Funding The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

FINE. we are fine. We are quite far from the quake. Japan is seeing several meters of waves. We will see much less.
It will rock and surge a bit, and folks shoukd stay outta if the water because it will be unpredictable but this is not a massive thing.

Now let me tell you about our king tides…

Exclusive | White House Seeks Payments From Other Universities—Including Harvard—After Columbia Deal Sets Precedent The Trump administration is in talks with several schools about future funding following allegations of antisemitism.

Nice little university you’ve got there. Shame if something happened to it.

www.wsj.com/us-news/educ...?

They will try to use it. We want them to learn it lies and hallucinates

you are a lab head, this affects you; if you are a student, this threatens your future The NIH grant system was already hyper- competitive before Trump. This policy will make it brutal. Without immediate resistance from the research community, this policy will go forward with devastating consequences for US science. What can you do? • Contact your Congressional representatives. It is best to show up in person. Explain and tell them to oppose this forward funding mandate. Share this article if it helps! Tell them to protect NIH funding. • For researchers: Make noise within your institution. Ask your research office what they re doing to push back. Talk to your program officers. Demand transparency. • Tell your local press that Trump is destroying US medical research, and find local activist groups to reach out to. • There are many engaged citizens across the country affected by cancer, or Alzheimer's, that want more information from scientists to help them advocate to their elected officials and to the press. Offer to talk to them, and help them do

this ends with a description of what YOU can do.

Please get involved now.
Everyone can take one of these actions.

#academicsky i teach s senior capstone genetics class in which the final assignment is a review of a recent paper . Im wondering how to create AI inoculation. Thinking of asking the students to ask ChatGPT to do the assignnent and then critique that. Thoughts?

few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history

I feel ill
Everything i have cared about being destroyed

JFC SO MANY people suck right now

and like EPIC suckage

It's just so hard to see and experience

Half my career was spent doing lab research in support of this goal. To be privileged enough to see it reached is humbling. To be aware enough to know that this kind of success will be denied future researchers because of this administration is anguish.

This make me ill. So much loss.

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

www.science.org/content/arti...

I mourn the pain, grief, suffering, and death this policy will cause

once upon a time it was considered a great thing to be a wizard, a shaman, a Jedi warrior — someone who can summon “magic” to do needful things

we need that “magic” which is actually reality

Outstanding thread.

And none of this would have been possible without NIH funding.

None of it.

NIH funding was the engine behind this cure as well as just about every other biomedical therapy and cure in modern history.

Alert: The Trump administration is quietly slashing new NIH grant awards, and it's not via the budget NIH’s sudden move to multiyear grant funding is forcing shocking cuts in the number of grants funded. This is an effective budget cut. It's bad, folks.

New, from an anonymous NIH insider: Trump is being pushed to spend more NIH money. The White House is ordering NIH to do multi-year budgets for awards. This budget trick means fewer awards, fewer labs funded, and lower paylines for researchers. 🧵
donmoynihan.substack.com/p/alert-the-...

National Institutes of Health v. American Public Health Association When political ideologies interfere with science, everyone loses.

Right now, the continuation of many restored NIH grants relies on the SCOTUS shadow docket. SCOTUS is not immune to pressure.
Also, if you are represented by one of the 14 R senators that called for the restoration of NIH grants, please write them a thank you. Good behavior should be rewarded.

I am demoraized ans depressed as all that i value is attacked by people who are at best ignorant but more often malevolent, cruel and evil

three principles I believe in: the dignity and worth of all human beings; the rule of law in protecting us all from injustice; and the importance of reason and empathy in addressing society’s biggest problems

all three are under attack and the institutions who are supposed to uphold them are dying

Post Sunday morning shows Bhattacharya email...

An Accurate Organizational Chart of Your University In accordance with our informal tradition of updating documents every thirty years, whether they need it or not, our university is pleased to prese...

#AcademicSky
🤣
www.mcsweeneys.net/articles/an-...

I think they only survive with international satellite campuses