Cristóbal Lecaros, MD MBI

An illustration showing the select inflammatory and immunologic processes relevant to drug reaction with eosinophilia and systemic symptoms (DRESS).

The immunopathogenesis of DRESS (a serious drug-induced T-cell–mediated condition with marked cutaneous and systemic effects) is considered to be complex, and much remains unknown. Learn more in a new review: nej.md/3ONkyL9

🧪 #MedSky

ICIs Result in Increased Rates of High-Grade irAEs for Older Patients With Breast Cancer The risk of developing high-grade immune-related AEs was heightened among patients with breast cancer who were older and who had chronic kidney disease.

ICIs Result in Increased Rates of High-Grade irAEs for Older Patients With Breast Cancer www.onclive.com/view/icis-re... #SABCS24

ACR Journals on Air podcast banner

New ACR Journals on Air podcast episode! How can we improve therapies for cutaneous lupus & dermatomyositis? Victoria P. Werth, MS, MD, explains the science behind type I interferons & their role in these autoimmune diseases.
Listen → acr.tw/3ZmyCji

There was a wonderful talk at PyData Amsterdam last year on using machine learning to study and preserve artworks at the Rijksmuseum, strong recommend.

youtu.be/kMfl5SzfkVc?...

Here the work of the protein fusions:
www.jidonline.org/article/S002...

Deficient mismatch repair is detected in large-to-giant congenital melanocytic naevi: providing new insight into aetiology and diagnosis This study detected deficient mismatch repair (dMMR) in large to giant congenital melanocytic naevi (LGCMN), which may provide new insight into aetiology.

Fascinating work by Wei et al at bjd demostrating that deficient mismatch repair causes in part large congenital melanocytic nevi; this along with Kinsler's paper at jid resolving non-nras/braf congenital nevi are so awesome
academic.oup.com/bjd/article-...

<em>Journal of the European Academy of Dermatology and Venereology</em> | Wiley Online Library Click on the article title to read more.

Developments in digital intelligence for dermatology - Tschandl onlinelibrary.wiley.com/doi/10.1111/...

Ok #medsky, here's my first attempt at a #dermsky #starterpack! Join us and follow along for all those interested in skin health, fun, and chatter!

Let me know if I missed someone so I can add them on here!

go.bsky.app/AkuEjW

two monkeys are playing with a skull in a room ALT: two monkeys are playing with a skull in a room

We also provide a survey of conditions in skin and found the work valuable in the sense of understanding what we are, who we are. 💀∎

data.mendeley.com/public-files...

Nanostructure and mechanics of mummified type I collagen from the 5300-year-old Tyrolean Iceman | Proceedings of the Royal Society B: Biological Sciences Skin protects the body from pathogens and degradation. Mummified skin in particular is extremely resistant to decomposition. External influences or the action of micro-organisms, however, can degrade ...

(3) and collagen I –a quite rigid structure that has shown barely any changes after >5300 years in other mummies

royalsocietypublishing.org/doi/10.1098/...

https://www.jidonline.org/article/S0022-202X(21)01687-0/fulltext

(2) lipids maintaining a very stable state of matter,

www.jidonline.org/article/S002...
youtu.be/jVlmOSEZ0K0?...

https://elifesciences.org/articles/19593

We believe that this preservation is due to biophysical properties of skin: eg (1) the pomegranate configuration of keratinocytes;

elifesciences.org/articles/19593

Fig 2 A, Dermatoscopy and histology of the mummy “El niño del Plomo.” Follicular openings and perifollicular pigmentation in skin from the trunk of the mummy (blue arrow). B, Exogenous pigmentation, dermatoglyphs, and acrosyringiums of the plantar region (white arrow). C, Histopathologic examination of plantar skin. The plantar skin sample showed thickening of the stratum corneum and black-brown particulate material of exogenous type in the superficial zone, consistent with dust particles. The melanin pigment status in the specimen was normal. (Hematoxylin-eosin stain; original magnifications: ×4 and ×10.)

We described dermoscopic findings and also how shocking well preserved structures were maintained!

Fig 1 The mummy “El Niño del Plomo.” Spontaneous natural mummification of an 8-year-old infant.

Integuments of mummy “El niño del Plomo”. (A) Well preserved braided hair. (B) Beau's lines in the foot nail. (C) Empty nits of Pediculosis capitis. (D) Hyperkeratosis and hyperpigmentation of the plantar region of the feet. (E) Paled erosion due to prior manipulation for a skin sample. (F) Subungual hematoma.

We had the opportunity to examine a Chilean mummy that was found about 500 years ago and corresponds to an Incan prince. Now it is under care of The Natural History Museum

www.mnhn.gob.cl/colecciones/...

The fantastic overview of Dr Eve Lowenstein (great talk at AAD this year also) settles the horizon of this interdisciplinary science, as "the study of integuments and its diseases as found in former remains"

doi.org/10.1016/s019...

Paleodermatology: Dermatoscopic findings of “Niño del Plomo” an Incan mummy in Chile

Residency works: Thrilled that this interdisciplinary project was published in @Jaadjournals!
It is all about… Paleodermatology! 🔍🏔️

pmc.ncbi.nlm.nih.gov/articles/PMC...

Hi! Fantastic initiative and congrats for your brilliant tutorials! I’ve learnt so much from them (umbilicated papules, id scalp, mf..)

Let’s bring back the club classics 👀

Hello! I enjoyed the old times when #dermtwitter was a thing and were superb tutorials or summaries of new works, commentaries by the authors themselves, a jc 📚 and so on..