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Young-Pearse Lab

@typlab.bsky.social

The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members. Find us at: youngpearselab.bwh.harvard.edu

363 Followers  |  406 Following  |  31 Posts  |  Joined: 10.01.2025  |  2.2088

Latest posts by typlab.bsky.social on Bluesky

Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!

31.07.2025 11:49 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu πŸŽ‰

The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!

10.07.2025 21:47 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! πŸ•πŸ§  She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

13.06.2025 18:26 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...

13.06.2025 10:43 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting!

@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s

@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s

12.06.2025 21:15 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

05.06.2025 00:49 β€” πŸ‘ 19    πŸ” 13    πŸ’¬ 0    πŸ“Œ 0
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Proud of our amazing postdoc @heuerwego.bsky.social πŸ‘ who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

04.06.2025 22:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! πŸŽ‰ Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

04.06.2025 02:09 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! πŸ†πŸ“– We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! πŸŽ‰πŸ½οΈ

03.06.2025 00:29 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸŽ“Congratulations to our incredible grads! πŸŽ‰
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! πŸ₯‚
We’re so proud of all you’ve accomplishedβ€”and can’t wait to see what you do next! πŸ’« @alexlish.bsky.social

31.05.2025 15:44 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
GBM-Masterpreis - Homepage der Gesellschaft fΓΌr Biochemie und Molekularbiologie e.V.

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! πŸ†πŸ§¬
Emma earned it for her work in Biomedical Neurosciences at TUM! πŸŽ“πŸ§ 
πŸ”— gbm-online.de/de/studium-k...

30.05.2025 11:06 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD.

Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.

21.05.2025 18:12 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 1    πŸ“Œ 1
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Big shoutout to our lab at the annual ROSMAP meeting in Chicago!

πŸŽ‰ @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award πŸ†

🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!

21.05.2025 20:20 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Alzheimer’s Risk Variants Leave Astrocytes CLUless | ALZFORUM

Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!

15.05.2025 09:45 β€” πŸ‘ 11    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!

14.05.2025 23:19 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
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Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!

14.05.2025 22:00 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Tracy gave a great presentation at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25

10.05.2025 19:54 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.

Read here www.sciencedirect.com/science/arti...

30.04.2025 15:51 β€” πŸ‘ 37    πŸ” 20    πŸ’¬ 1    πŸ“Œ 0
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CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish etΒ al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

30.04.2025 15:56 β€” πŸ‘ 21    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
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Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!

11.04.2025 23:50 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to TYP lab postdoc @kelliannealexa1.bsky.social on an amazing talk at the Cold Spring Harbor Barriers meeting!! Keep a lookout for all the cool work Kellie is doing with iPSC models of the BBB!

10.04.2025 17:49 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 2
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Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!

10.04.2025 12:15 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Some members of the TYP lab had a great (and only mildly frigid) outing to Fenway to see the Red Sox play this week!

10.04.2025 12:06 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1

@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"

28.03.2025 22:27 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Zach Augur will be presenting a poster during Shift 1 on April 2nd and 3rd titled "BAG3 IN ALZHEIMER’S DISEASE AND ITS IMPACT ON ASTROCYTE FUNCTION AND DISEASE PROGRESSION"

28.03.2025 22:13 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!

28.03.2025 22:12 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1
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Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!

06.03.2025 00:41 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

28.02.2025 22:16 β€” πŸ‘ 15    πŸ” 4    πŸ’¬ 0    πŸ“Œ 2

πŸš€ Excited to share our latest work uncovering the cell-cell signals driving an #astrocyte state linked to cognitive decline in #Alzheimer’s 🧠✨ Huge thanks to my amazing collaborators Aiqun Li, Bin Zhang, Roland Friedel, @typlab.bsky.social, David Bennett!
#SingleCell #SpatialTranscriptomics #Glia

27.02.2025 03:39 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to PhD student @zacharyrmurphy.bsky.social for passing his preliminary exams and officially becoming a PhD candidate through the Harvard BBS program! Zack is excited to get started on his project using stem cell models to investigate sex differences in AD!

20.02.2025 22:42 β€” πŸ‘ 12    πŸ” 0    πŸ’¬ 0    πŸ“Œ 3

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