Rogan Grant

It would be great to find out if Patel is still sending new agents to the Holocaust Museum as part of their training. We went in the first week and after seeing the museum had a discussion about complicity and law enforcement that was led by someone from the ADL. This was started in 2001 by Freeh.

Beeswarm plot of the prediction error across different methods of double perturbations showing that all methods (scGPT, scFoundation, UCE, scBERT, Geneformer, GEARS, and CPA) perform worse than the additive baseline.

Line plot of the true positive rate against the false discovery proportion showing that none of the methods is better at finding non additive interactions than simply predicting no change.

Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉

www.nature.com/articles/s41...

We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!

🧵

Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.

Harvard University Loses Student and Exchange Visitor Program Certification for Pro-Terrorist Conduct | Homeland Security Today, Homeland Security Secretary Kristi Noem ordered DHS to terminate the Harvard University’s Student and Exchange Visitor Program (SEVP) certification.

Absolutely nothing could every justify this. DHS revokes status for CURRENT foreign exchange students, blocks future enrollment www.dhs.gov/news/2025/05...

Screenshot of NIMH BRAINS funding opportunity. The expiration date is now before the next application due date.

NIH moved up the expiration date for some funding opportunities, effectively *canceling* the next application date without removing it from the standard table. I can't even imagine how many people are still prepping these grants.

👀 List of impacted opportunities:
grants.nih.gov/grants/guide...

If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.

Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025

Co-sign (as a cis het white man whose father went to college.)

The broad classes of science and scholars lumped under “DEI” has been some of the most productive and insightful we have seen in medicine with huge benefits throughout the system

"NIH funding is gone, so you should pivot to private foundations for funding"

Meanwhile, private foundations:

i'm just a senior postdoc, standing in front of a career that i have worked really hard for, asking higher education in the united states to not completely implode in front of my eyes before i even get a chance to say the words 'my lab studies'

Low-level processing of spatial transcriptomics data has me re-learning geometry and linear algebra and I am not terribly happy about it

Opinion | Larry David: My Dinner With Adolf When a private meeting goes unexpectedly.

Absolutely brutal and hilarious takedown of Bill Maher from the one and only Larry David.

Nation Can’t Believe It On Harvard’s Side

Nation Can’t Believe It On Harvard’s Side

Very thankful to Haverford for standing up, considering their only superdonor is a prominent member of the administration. Do better, UW.

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

Forcing people to pay $130 for a passport in order to vote is just a Jim Crow poll tax by another name.

It is blatantly unconstitutional.

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

Rep. Steven Horsford to Greer: "So the trade representative hasn't spoken to the POTUS about a global reordering of trade, but yet he announced it on a tweet? WTF! Who is in charge? It looks like your boss just pulled the rug out from under you. There is no strategy ... is this market manipulation?"

If the agent of an embittered KGB officer somehow won the US presidency and entered into the office bent on destroying the USA in its national influence, network of alliances, and the American people’s quality of life, what would he be doing differently?

Trumpism has turned out to be DEI for people with immense privilege who failed entirely on their own merits and punishment for those with a modicum of success

We hang together or we hang separately. Could not be clearer what is happening and how universities must respond.

Is it possible to short an index fund?

We are excited to announce our 2025 Schmidt Science Fellows! 32 early career researchers, nominated by the world’s leading research universities, who will take an interdisciplinary approach to advancing discovery schmidtsciencefellows.org/news/2025-fe...

🔥🔥🔥

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

The massive changes in US research brought about by the new administration of President Donald Trump are causing many scientists in the country to rethink their lives and careers

https://go.nature.com/41OhAgK

White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.

How Metabolism Can Shape Cells’ Destinies | Quanta Magazine A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...

I would love for someone to explain to me what this has to do with scientific research or the funding that supports it

Decoding cell–cell communication using spatial transcriptomics Nature Reviews Genetics - In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with...

Review: Decoding cell–cell communication using spatial transcriptomics www.nature.com/articles/s4...

ICYMI, NIH will be asking soon for each NIH-funded researcher to justify every draw they make (often several times a week) on their grants and every NIH officer and their boss will have to justify their agreeing on these draws.

This is the death of US biomedical research by a thousand cuts