Audrey Leprince

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

graphical abstract of the article the extended mobility of plasmids

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

1/6 Excited to share our review 🚀
🧬 CRISPR–Cas therapies targeting bacteria!
#MicroSky

Our paper on how integrons are biobanks of novel minimal defense systems is now out www.science.org/doi/10.1126/... Two main conclusions on this excellent work led by @eloilittner.bsky.social @baptistedarracq.bsky.social 1/n

Check out our latest Science Story "NMDC Community members put mobile metadata management to the test" featuring 2023 Ambassador and Champion Thomas Pitot and how his field experiences contributed to the development of our newly released Field Notes mobile app! microbiomedata.org/2025/04/28/n...

New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)

Now encompassing 263 systems (+111 this year..!).

Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models

Check out our latest #phagetherapy review in Nature Reviews Methods Primers.

rdcu.be/d9H92

Happy to share a conceptual schematic for a “phrinter (phage printer)” 😊

Many thanks to all co-authors, editors and reviewers!

This is going to be a #phage -tastic conference!
@spp2330.bsky.social

What is the diversity of antiphage systems out there ?

We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.

Leb by E. Mordret.
www.biorxiv.org/content/10.1...

Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...

Viral niche-partitioning: Comparative genomics of giant viruses across environmental gradients in a High Arctic freshwater-saltwater lake Abstract. Giant viruses (GVs; Nucleocytoviricota) impact the biology and ecology of a wide range of eukaryotic hosts, with implications for global biogeoch

Beautiful work by Thomas Pitot as well as by @simrouxvirus.bsky.social, @ai-cy.bsky.social, @vincentsomerville.bsky.social, et al. !

academic.oup.com/ismecommun/a...

Here's the visual proof of why vaccines do more good than harm See year by year how vaccines beat back nine dangerous infectious diseases

Sadly, it’s a good time to once again share this amazing infographic that we ran at @science.org more than 7 years ago
🧪 #IDsky
www.science.org/content/arti...

Sharing new tools made by Artyom Egorov in my group!
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...

Thanks for putting this list together! Could you also add me?