Aydan Szeto

👀👀 @ilc6.bsky.social
#excited

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!

Grand Prize: $25K & your essay published in Science Magazine

Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH

My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.

https://buff.ly/3BdtFkS

Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org

Welcome to bluesky Sarah! Rod Rahimi assembled several immunology starter packs in case you’d like to connect with them :)

bsky.app/profile/rodr...

Notching up a win: fresh tools for activating Notch Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.

#immunosky

Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!

www.nature.com/articles/d41...

RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?

(Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester on FindAPhD.com PhD Project - (Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester, listed on FindAPhD.com

New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...

#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...

Should we “normalise” the gut myco(& micro)biome across facilities to increase reproducibility? What is normal?

The authors further showed that mice from JAX lab (where many of us get lab mice from) lack this commensal. Differences in mycobiome can dramatically influence immunity.

In @nature, Liao et al showed this commensal promotes type-2 immunity in the gut via IL-33/ST2, influencing protective anti-helminth responses and food allergy models.

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.

www.nature.com/articles/s41...

Why I have resigned from the Royal Society The Royal Society is a venerable institution founded in 1660, whose original members included such eminent men as Christopher Wren, Robert H...

New blogpost:
deevybee.blogspot.com/2024/11/why-...

Happy to answer any specific questions you may have and/or share my experience either here or privately :)

We used BD Cytofix/perm, Foxp3 fix/perm or 2% PFA fixation and these were all compatible with 2W1S tetramer staining and downstream cytokine analyses by flow

I can still see some after stimulation, so it’s not like the stimulation will completely negate tetramer staining (at least for 2W1S-MHCII tetramers). Worth a try!

Agree with the above and I will add that at least for class 2 tetramers, it will depend on the specific tetramers that you use. Unfortunately a lot of the class 2 tetramers are not great compared to class 1, and in my experience both the MFI and % positives may reduce after stimulation, but

Research Assistant in Tissue Immunology:Oxford Road

🚨🚨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!

Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social

#Immunosky #LGBTQSTEM 🏳️‍🌈🏳️‍⚧️🧪 #Academicsky

www.jobs.manchester.ac.uk/Job/JobDetai...

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network

Below are the links

If you're an immunologist and I have missed you so far, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

Yesss!!!

#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.

Can I be added please :)

Some of us already hallucinate more than others and we definitely don’t need more of that

Hyaluronan and collagen III expression in allergic lung

New Slains castle at Cruden Bay

My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.

#immunosky

B cell and TFH researchers:

Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...

ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...

go.bsky.app/Eaua5Jk my starter for neuroimmunology

A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.

go.bsky.app/AjNpW2h