Simon Cleary

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Closing date 7th August.

Please do consider applying!

my.corehr.com/pls/coreport...

Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways:
rdcu.be/ewCMo

Congrats Chou Chou, Hasina Outtz Reed and colleagues!

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients Cook et al. investigate the metabolic profile of DLBCL patient-derived CAR-T cells ex vivo. Comparing Axi-cel (CD28-co-stimulated) and Tisa-cel (4-1BB-co-stimulated) products, they find divergent meta...

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Epithelial damage and ageing: the perfect storm Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchymal scarring that is triggered by repeated microinjury to a vulnerable alveolar epithelium. It is increasingly r...

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social

thorax.bmj.com/content/earl...

Public access link: rdcu.be/er3Iq

Interested in new ways to study interactions between cancers and the immune system? If yes, have a read of this article on mine and Longhui Qiu's recent work, featured in Nature Reviews Cancer's Tools of the Trade series: rdcu.be/er3Iq

Image captured by a light-sheet microscope showing the arterial tree of an adult mouse kidney in magenta

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

My PhD student isolated some liver endothelial cells and got this brilliant image showing the gradual transition of health EC to full EndMT in a very satisfying circle. #fluorescencefriday #fibrosis

Need help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help!

www.eurobioimaging-access.eu/nodes/uk-node

Very excited about this paper that came online today! InterpolAI can predict missing image data from light microscopy to H&E to MRI for improved volumetric imaging and image analysis.

You did scRNA-seq of the lung, but can't decide on stromal annotation? Or trying to pick up Xenium probes? We got you! We wrote a review of stromal heterogeneity in the adult lung delineated by recent single-cell genomics studies. journals.physiology.org/doi/full/10....

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations Nature Cardiovascular Research - Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth...

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in ‪@natcardiovascres.nature.com by Marle Kraft et al.

rdcu.be/enhST

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma - Nature Immunology Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing alarmins, chemokines and a un...

🚨 We did it! Our latest work—led by my lab and the @lloydlab.bsky.social is now published in Nature Immunology! 🎉

Using single-cell spatial transcriptomics, we provide the first map of the airway wall.

🔗 www.nature.com/articles/s41...

#spatialbiology #asthma #mastcells #lungimmunology

*Paid internship opportunity*

@biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and
@focalplane.bsky.social

If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇

Amazing imaging and useful research from @daniyaljafree.bsky.social !

Thanks!!

Our work featured on the cover of this month's J Exp Med!

One week left to apply! Join my lab in beautiful Vienna for your #PhD studying #metastasis.

🚨 Exciting news for #UKCellMicro2025!

The meeting is now supported by the EMBO Young Investigator Programme
We’re thrilled to have their backing for this year’s meeting. 🌟
🔗 Full details & programme: www.ukcellmicro.org
#CellMicro #ECR #EMBO

Fancy an academic job in London? Apply below and come join us at our amazing institute! 👏🧪🧠 #PainResearch #PainScience

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal!

doi.org/10.1242/dmm....

We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)

Excellent study putting together important pieces of the puzzle of why lymphatic endothelial cells resemble puzzle pieces! 🧩

Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast on FindAPhD.com PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare
- any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

How Our Lungs Back Up the Bone Marrow to Make Our Blood A new UCSF study shows that the human lungs have just as many blood-producing stem cells as bone marrow. These stem cells are a precious resource for a variety of therapies for conditions like leukemi...

Nice news feature on Cathi Conrad's identification of a reservoir of functional haematopoietic stem cells in human lungs! www.ucsf.edu/news/2025/02/429531/how-our-lungs-back-bone-marrow-make-our-blood

Awestruck by these cage-like structures that regulate escape of megakaryocytes from bone marrow into blood vessels.

Congratulations to authors of this study, which I see is now also available as a reviewed preprint at eLife: elifesciences.org/reviewed-preprints/104963v1

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social
doi.org/10.1084/jem....

Check out our movie featured as Biomedical Picture of the Day! 'Bluetorial' in preparation!

Research Assistant (177885) We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Fränze Progatzky at the Kennedy Institute.

🚨 We have TWO exciting open positions in our lab! 🚨

We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:

🔬 Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...

💻 Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...

📢 Please share!