Simon Cleary

Love these 3D renderings of the extracellular matrix cages surrounding megakaryocytes!

bsky.app/profile/wcla...

Fun revisiting this study and looking at the eLife peer review system for this postLight:

Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!

Doctoral INPhINIT fellowships - Incoming Call 2026 We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

Outstanding PhD fellowship call OPEN for excellent students.

lacaixafoundation.org/en/doctoral-...

This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).

If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!

Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week!

Great line-up of speakers. Send an email if you would like to meet at or around the conference.

Reader in/Professor of Immunobiology | King's College London

We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP.
www.kcl.ac.uk/jobs/131447-...

Getting distracted like @bryanwelm.bsky.social states above - the slide drawn by the Family Guy animators has incompatible gears that would either never or always grind and are not in contact with each other. Weak, distracting messaging.

'B' frequently happens and would grind my gears if it weren't so funny.

Great to hear good news on reproducibility!

Nice! Interesting that the screenshot seems to reference the 'arsenic life' paper but not mentioned in the blog post, what's the story behind that?

DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....

Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:

Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability The antiparasitic drug ivermectin was proposed as a repurposed drug for the treatment of SARS-CoV-2 infection based on in vitro studies, but proved ineffective in high-quality clinical trials. When ex...

Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵

It’s official! 🎉
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇

Bioimage Analysis Specialist | King's College London

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Enhancing pulmonary vascular function to heal injured lungs - MRC DTP To develop improved treatments for inflammatory diseases, we need a better understanding of how pro-inflammatory leukocyte responses resolve. During inflammatory resolution, some recruited leukocytes ...

PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues!

Please forward to any suitable undergraduates/MSc students/research assistants.

Info: kcl-mrcdtp.com/project/enha...

Pleased to see this out now in @jem.org 🔬

We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

🚨 New paper in @jclinical-invest.bsky.social!

Kidney lymphatics are a promising target in transplant rejection

🗺️ In rejection, lymphatics expand and adversely remodel

⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system

www.jci.org/articles/vie...

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Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

New postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...

PhD opportunity: please contact me if you know someone with a strong interest in respiratory science who would like to apply for a Sir David Jack PhD scholarship.
Details here: www.bps.ac.uk/membership-a...
Course fee waivers possible for outstanding international students.

Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

Vav-Cre has been transformative for the field, but it is a pain in the a** of a line to work with. Has anyone made a better pan-hematopoietic line? Which one? How specific is it?

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Closing date 7th August.

Please do consider applying!

my.corehr.com/pls/coreport...

Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways:
rdcu.be/ewCMo

Congrats Chou Chou, Hasina Outtz Reed and colleagues!

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients Cook et al. investigate the metabolic profile of DLBCL patient-derived CAR-T cells ex vivo. Comparing Axi-cel (CD28-co-stimulated) and Tisa-cel (4-1BB-co-stimulated) products, they find divergent meta...

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Epithelial damage and ageing: the perfect storm Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchymal scarring that is triggered by repeated microinjury to a vulnerable alveolar epithelium. It is increasingly r...

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social

thorax.bmj.com/content/earl...