The Lajoie Lab

Preprint: Chikungunya virus persists in joint associated macrophages and promotes chronic disease
www.researchsquare.com/article/rs-6...

Piezo1 senses hyphae and initiates host defense against pathogenic fungi Shi et al. demonstrate that the mechanically activated ion channel Piezo1 serves as a critical sensor for innate immune cells, enabling them to distinguish the invasive hyphal form of C. albicans from...

#WeekendRead! #ImmuneMechanosensing! Zhou &co show @cp-cellreports that rigid pathogenic candida hyphae are sensed in phagocytes by Piezo1 which upregulates Dectins & other CLRs via CREB-C/EBPb & drives antifungal NLRP3 activation via NDR1/2!
www.cell.com/cell-reports...

Fonta et al. show that #oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS #autoimmunity. IL-33 ablation reduces persistence & TCF-1low effector T cell generation. rupress.org/jem/article/...

📘 In #Neuroimmunology & #Neurodegeneration 2025: rupress.org/jem/collecti...

Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

This is cool! #Immunology 🧪

Graphical abstract for the linked paper. Top) A diagram depicting the optical properties of nano-composites used to create the near-IR contact lens system. Middle) A diagram showing how different wavelengths of near-IR light can be shifted into the visible spectrum. Bottom) A diagram depicting a wearable eyeglass system with the same capabilities of the contact lens system described in the middle of this graphical abstract.

Experimental contact lenses now allow humans (and mice) to see near-infrared light by converting it into visible wavelengths. No power source needed! 🧪

www.cell.com/cell/fulltex...

Closed-loop vagus nerve stimulation aids recovery from spinal cord injury @nature.com
www.nature.com/articles/s41...

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma
www.nature.com/articles/s41...
@natimmunol.nature.com @regisjoulia.bsky.social

Cholinergic regulation of thymocyte negative selection
www.nature.com/articles/s41...
@natimmunol.nature.com

When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday

Neutrophils: not just infection fighters! 🧬

New review connects them to food allergies, eczema, and asthma.

Could they be future targets for therapy?

🔗 bit.ly/3GReFeX

#FoodAllergyAwarenessWeek

Our work featured on the cover of this month's J Exp Med!

Its enriching to see young talent develop! Proud mentor moments-all 3 of my Ph.D students @aishwaryamagesh.bsky.social @atakkatan.bsky.social and IanMcKnight got selected for podium presentations at #AAI2025 @johnshopkinsmmi.bsky.social @jhu.edu

Had a wonderful time presenting at the international complement society guest symposium at #AAI2025. A big shoutout 👏👏👏to my 2 very talented Ph.D students @aishwaryamagesh.bsky.social and @atakkatan.bsky.social for making this work possible! @johnshopkinsmmi.bsky.social

Honored to have been invited to the #AAI2025 International Complement Society (ICS) Guest Symposium. Big shout out to Claudia Kemper and Jessy J Alexander for organizing the symposium.

Enjoying #AAI2025 and learning a bunch of new science with folks from the lab ! #immunology2025

If you are looking to COMPLEMENT your knowledge of Th2 immunity, please read our latest review.

It’s #CRSwNPAwarenessDay!
We’re honored to team up with microscopy artist 𝐒𝐭𝐞𝐯𝐞 𝐆𝐬𝐜𝐡𝐦𝐞𝐢𝐬𝐬𝐧𝐞𝐫 to show CRSwNP like you’ve never seen it before. More here: theworldcloseup.com
Images are copyright protected—view & license at: www.sciencephoto.com/search?q=chr...
#AirwayHealth #CRSwNP #ScienceArt

Review @jimmunol.bsky.social
Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease
academic.oup.com/jimmunol/adv...

New technique expands tissues so hundreds of biomolecules can be seen inside cells A new tissue expansion method developed by Janelia and University of Wisconsin-Madison researchers enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules

🥼A new tissue expansion method developed by researchers in the Wang & Tillberg labs & collaborators @uwmadison.bsky.social enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations ➡️ hhmi.news/4ixHOZZ

Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

#immunosky Obsessed with our robotic arm loading plates to our Sony ID7000 spectral analyser to dramatically increase our flow throughput. This cytometer literally never blocks so we have complete trust in the whole system to run samples overnight whilst we sleep 😴

Matrix-producing neutrophils populate and shield the skin - Nature A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!

That’s gold!

Meeting the person you suspect is reviewer #2 in a conference

can you explain this 3 year gap in your resume?

yeah the paper was under review

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!

Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth
www.nature.com/articles/s41...
@naturecomms.bsky.social

GABA production by enteric neurons suppresses ILC3 activation to prevent inflammation and maintain gut homeostasis @natimmunol.bsky.social
N&V by @hepworth-lab.bsky.social
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...

Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
www.cell.com/cell-genomic...