Sarah Ross

Well, this is rather wonderful! #IUIS2025

The human immune system evolved over millennia - and can adapt within a single lifetime. This review examines how the immune responses change over the life course. By Jessica Metcalf, Andrea Graham, Andrew Yates and Derek Cummings @science.org

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Tissue immunity meets biological sex differences - context is important in the immune system. Another of my reading recommendations during a trip to @iuis-online.bsky.social Congress. From Sonia Sharma, Alicia Gibbons and Erica Ollmann Saphire in @science.org

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If you are looking for a great read during your journey to @iuis-online.bsky.social Congress, take a peek at this review from from Matthias Nahrendorf, Florent Ginhoux and @filswirski.bsky.social in @science.org that explores the role of immune cells beyond host defence.

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Anyone traveling to @iuis-online.bsky.social Congress and looking for something to read? Don't miss the reviews from our @science.org Evolving Immunity Special Issue!
Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences.

buff.ly/IU4nbSE

Such a beautiful and intricate image! I was fascinated by the creative process for the cover, and loved getting a behind-the-scenes look at the work of artist Rioka Hayama and the Science Visuals team. Have you guessed all the features yet?

Not long to go - I'm looking forward to some fantastic immunology!

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

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By Jobin, Seetharama, Rüttger et al.

#Immunology out now @science.org

Regulatory T cells inhibit pain sensing in female, but not male, mice.

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By Élora Midavaine, Sakeen Kashem et al.

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

#Immunology by First Release @science.org

In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.

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#Immunology out now @science.org

Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.

https://buff.ly/3QvxSVf

By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.

#Immunology out now @science.org

In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells.

https://buff.ly/4hBmL8W

By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al

ICYMI by First Release - now officially in print @science.org

Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.

https://buff.ly/4gvqKTz

From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.

#immunometabolism

Not long to go now! Don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!

Enter: buff.ly/4gS29ZH
More details: ⤵️

This Perspective from Aaron Ver Heul puts the work of Andrew Liu, @danhkaplan.bsky.social et al into context.

https://buff.ly/40Bp1G1

#Immunology @science.org

#Immunology out now @science.org

Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators.

https://buff.ly/4hDAgF2

From Andrew Liu, @danhkaplan.bsky.social et al

ICYMI by First Release - now officially in print @science.org

Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.

https://buff.ly/3BzpLmL

By Andrew MacLean, Michel Nussenzweig et al.

#Immunology

#Immunology out now @science.org

ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.

https://buff.ly/42iBst0

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!

Grand Prize: $25K & your essay published in Science Magazine

Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH

#Immunology by first release now @science.org

Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.

https://buff.ly/3BzpLmL

By Andrew MacLean, Michel Nussenzweig et al.

This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context.

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#Immunology @science.org

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

#Immunology out now @science.org

An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.

https://buff.ly/4grnf18

By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.

#Immunology out now @science.org

Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses.

https://buff.ly/4flV5TK

By Vamsee Mallajosyula, Mark Davis et al.

I am excited to say, we have not one but FOUR #Immunology Research Articles out this week @science.org! Individual posts to follow!

From Feb '24: A treatment combining a soluble IL-15 superagonist with broadly neutralizing antibodies against the HIV-1 envelope protein induced long-term viral control in rhesus macaques infected with SIV-HIV.

https://buff.ly/3ZZdYY4

#Immunology #HIV @science.org

From Sept '24: Computational approaches identified
a localized flexible region within the F protein of RSV that could be mutated to keep the protein in the prefusion state when used as a vaccine antigen.

https://buff.ly/4gAS8zy

#Immunology #Vaccines @science.org

From March '24: Investigation of variants in the pre-T cell receptor α (PTCRA) chain in humans.

https://buff.ly/3ZGq2wf

A collaboration, including Rik Schrijvers,@sarahhenrickson.bsky.social, Jean-Laurent Casanova and Vivien

#Immunology @science.org