Craig Anderson

Awesome @naxerova.bsky.social !!!!!

It's been a bumper week for super cool cancer genetics papers!!

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature Sex bias and association with smoking history&nbsp;identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men&nbsp;and smokers.

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social

DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

📢OUT @natgenet.nature.com

📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.

By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.

⬇️

www.nature.com/articles/s41...

Very cool! 🙌

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Protein language models reveal evolutionary constraints on synonymous codon choice Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases[1][1]-[4][2]. Almost all of these mosaic mutations begin as nucleotide mismatche...

An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease.

Explore the science behind it:
www.biorxiv.org/content/10.1...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

New paper out today in @science.org! Very proud that my team was able to contribute to this fantastic work from @bethpsaila.bsky.social's group. In short: platelets contain a fair amount of cfDNA taken up from the surrounding! Read the summary by lead author @l-cmurphy.bsky.social:

Congratulations- this is really, really cool!

PhD Student in Mutational Processes Driving Somatic Evolution

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...

You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Clone copy number diversity is linked to survival in lung cancer - Nature A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...

new out in Nature yesterday www.nature.com/articles/s41...

The molecular basis of human transcription-coupled DNA repair - Nature Cell Biology This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps i...

Dive into the step-by-step choreography of transcription-coupled DNA repair.

In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!

www.nature.com/articles/s41...

🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.

If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.

Formal ad coming soon. DM me!

Thank you to everyone who has supported me all along this journey- from everyone rad involved in the earthworms and moths to the insanely clever people who introduced me to the world of mice and humans. I'm very grateful.

Please stay and touch or better yet visit!

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing

www.biorxiv.org/content/10.1...

Postdoctoral Fellow in Coorens Group We are looking for a motivated and talented postdoctoral-level researcher with experience in genomic analyses to join the newly established Coorens group at EMBL-EBI. We study how normal cells in diff...

Last but not least, if you're interested in somatic mutations, new technologies and computational genomics - we're hiring a postdoc in my brand new lab
@emblebi.bsky.social!

Reach out if interested or you have any questions, and apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never&nbsp;smokers, and looks at the possible role of factors such as ...

new out in Nature this week www.nature.com/articles/s41...

We’re hiring!
Postdoc in Computational Genomics at
@uoe-igc.bsky.social

Focus: myeloma, structural variants, heterochromatin, multiomics

Deadline: 9 July 2025, 23:59 GMT

Apply: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

#myeloma #postdoc #genomics #bioinformatics #epigenetics #codeandkilts

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Really cool!

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...