Craig Anderson

Amazing!! Congratulations Sarah!

The abstract deadline for Mutations in Time and Space 2026 closes in 3 weeks time. Sign up here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...

As well as thrilling science, the programme includes dinner at the beautiful King's College in Cambridge.

@eventswcs.bsky.social

Decay of driver mutations shapes the landscape of intestinal transformation - Nature The order in which driver mutations of colorectal cancer occur in intestinal epithelium can determine whether clones are positively or negatively selected and can shape subsequent tumour development.

Nature research paper: Decay of driver mutations shapes the landscape of intestinal transformation

go.nature.com/49VIh7w

For those interested in cooperativity within and between enhancers, @wbickmor.bsky.social and I wrote a mini-review and perspective, inspired by the many recent papers on this topic.

doi.org/10.1016/j.gd...

This is insanely cool!!!!!

Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1

Spatial architecture of development and disease - Nature Reviews Genetics Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within ...

www.nature.com/articles/s41...

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.

1/n

new out in Nature www.nature.com/articles/s41...

🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
🧵 1/4
Please repost 🙏

Curious Cases - Series 24 - Immortal Jellies - BBC Sounds Hannah Fry and Dara Ó Briain ask whether a tiny jellyfish holds the secret to immortality.

Thrilled to announce that I'm on Curious Cases tomorrow at 10am on BBC Radio 4!

The episode - Immortal Jellies - looks at some remarkably long-lived species and what they can teach us about ageing. This is a key area of focus for our lab.
www.bbc.co.uk/sounds/play/...

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Come to Germany and do a PhD with DKFZ. You'll be supported by an international community doing amazing science in a fantastic place.

I joined the DKTK from the UK 3 months ago and couldn't be happier with how easy it has been fitting in. The quality of work here is phenomenal and you should apply!

📣 Paper alert!

I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry https://www.biorxiv.org/content/10.1101/2025.10.28.685157v1

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

Wellcome Connecting Science hybrid conference Mutations in Time and Space Conference dates: 13-15 April 2026 Location: Hinxton Hall Conference Centre, UK and online. Bursary deadline: 12 January 2026 Abstract deadline: 2 February 2026 In-person registration deadline: 16 March 2026 Virtual deadline: 6 April 2026

Explore the origins, patterns and consequences of mutations across biological systems! #MITS26

🗓️ Conference dates: 13-15 April 2026

Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬

Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics

Landscape of parental postzygotic mutations in >11,000 rare disease trios Postzygotic mutations (PZMs) arising post-fertilisation, prior to primordial germ cell specification, may be subsequently inherited by both somatic and germ cells, causing somatic mosaicism in the par...

New preprint from another part of my PhD! 📝👇

Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells.
By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet.

tinyurl.com/mvns2ytv

Mutations in Time and Space is headed to Cambridge, UK for 2026!

You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...

See you at the Wellcome Genome Campus, on 13–15 April?

Nice one! ;-) #MITS26

Awesome @naxerova.bsky.social !!!!!

It's been a bumper week for super cool cancer genetics papers!!

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature Sex bias and association with smoking history&nbsp;identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men&nbsp;and smokers.

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social

DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

📢OUT @natgenet.nature.com

📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.

By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.

⬇️

www.nature.com/articles/s41...

Very cool! 🙌

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Protein language models reveal evolutionary constraints on synonymous codon choice Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases[1][1]-[4][2]. Almost all of these mosaic mutations begin as nucleotide mismatche...

An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease.

Explore the science behind it:
www.biorxiv.org/content/10.1...