Craig Anderson

🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.

If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.

Formal ad coming soon. DM me!

Thank you to everyone who has supported me all along this journey- from everyone rad involved in the earthworms and moths to the insanely clever people who introduced me to the world of mice and humans. I'm very grateful.

Please stay and touch or better yet visit!

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing

www.biorxiv.org/content/10.1...

Postdoctoral Fellow in Coorens Group We are looking for a motivated and talented postdoctoral-level researcher with experience in genomic analyses to join the newly established Coorens group at EMBL-EBI. We study how normal cells in diff...

Last but not least, if you're interested in somatic mutations, new technologies and computational genomics - we're hiring a postdoc in my brand new lab
@emblebi.bsky.social!

Reach out if interested or you have any questions, and apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as ...

new out in Nature this week www.nature.com/articles/s41...

We’re hiring!
Postdoc in Computational Genomics at
@uoe-igc.bsky.social

Focus: myeloma, structural variants, heterochromatin, multiomics

Deadline: 9 July 2025, 23:59 GMT

Apply: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

#myeloma #postdoc #genomics #bioinformatics #epigenetics #codeandkilts

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Really cool!

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...

A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects Mutational signatures contain valuable information about the mutational processes shaping cancer genomes. However, despite dozens of tools to identify signatures in cancer samples, there is not an est...

If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...

Social media grump Kamila has finally made it onto Bluesky!

Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.

I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.

We are hiring!
Want to join my new group at the amazing @uoe-igc.bsky.social and perform ground-breaking studies in reproductive genomics and genomic medicine as a computational genomicist?

Please DM me to discuss this, I will be attending #ESHG2025

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy

Published @natcancer.nature.com

Melissa is an outstanding new clinician scientist.. one to watch.

www.nature.com/articles/s43...

@icr.ac.uk

Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis Hepatocellular carcinoma is the most prevalent primary liver cancer and arises from hepatocytes, which are very metabolically active and contain abundant mitochondria. Despite extensive characterisati...

🚨New preprint!🚨

Venturing out of the nuclear genome to explore #mtDNA:

"Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis"
www.biorxiv.org/content/10.1...

Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️

With the brilliant @mlockley.bsky.social we've been exploring chemo resistance evolution in ovarian cancer. We find resistance has a fitness cost which means resistant cells are outcompeted by sensitive cells when treatment is stopped.
aacrjournals.org/cancerres/ar...

@icr.ac.uk @qmbci.bsky.social

Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1...
#Genomics #SomaticEvolution

I had an incredible time at the Mutations in Time and Space conference last week! There were a ton of interesting talks and I so appreciate the engagement with my work. Excited for more! #MITS25

Proud to have Prof Nicky McGranahan #CRUKFunded who co-lead City of London Centre Cancer Evolution theme charing and speaking about immunology and somatic evolution at #AACR25!

If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism Nature Reviews Genetics, Published online: 25 April 2025; doi:10.1038/s41576-025-00832-3In this Review, Shao et al. discuss experimental and computational advances in single-cell DNA sequencing, insights into somatic genetic variation during normal development and in disease, and the potential use of single-cell somatic mutations for lineage tracing, diagnostics and biomarkers.

New online! Advances in single-cell DNA sequencing enable insights into human somatic mosaicism

Thank you to the Mutations in Time and Space #MITS25 organisers (and fellow attendees!) for a fantastic few days of Dynamic, Exciting, and Interesting science and people @broadinstitute.org A great week with old friends and collaborators, and making new ones... See you again in 2026 💙

Mutations in Time and Space 2025 #MITS25 was a fabulous meeting! So much science to digest over the weekend. Special thanks to the Broad for hosting.
A special art connection between the MIT campus and the Allen Institute (my next door neighbor) in Seattle. Shared Jaume Plensa sculptures.

Bye Boston. It was a great conference. #MutationsInTimeAndSpace

This meeting wouldn't have been possible without our amazing sponsors and all the great attendees. Thanks everyone!! #MITS25

The best speaker prizes go to
Jennifer Ziegenfuss and Sarah Carioscia!!
#MITS25

Well done to the poster prize winners #MITS25
Daan Andel
Bradley Class
Duncan Odom
Sean Laidlaw