Martin Taylor

Under the microscope: DNA damage tracked through cell generations | Nature An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer. An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer.

🔬Under the microscope: DNA damage tracked through cell generations🔬

It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com

rdcu.be/em0qi

@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social

21.05.2025 15:56 — 👍 20    🔁 6    💬 1    📌 0

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

Adverts with full details below ⬇️

26.03.2025 15:31 — 👍 24    🔁 31    💬 2    📌 1

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating...

This is just brilliant. New tool dissects immune profiles from WGS. Gives novel insights into >90k (!) tumours, highlights circulating immune changes https://buff.ly/41y6Hzz Found with researchbriefing.com

21.02.2025 09:00 — 👍 3    🔁 1    💬 1    📌 0

[2/2] Within a strain, that's divergence from a common starting point. The more heterogeneity (divergence) amongst tumours generated, the less the path of tumour development has been fully determined by the controlled variables.

16.01.2025 18:05 — 👍 1    🔁 0    💬 1    📌 0

[1/2] Throughout the paper we do talk about convergence of phenotypes between strains. For each strain the we took the same starting point (genetics, environment, sex, exposure) and asked how consistent were the tumours produced (same drivers, mutations, expression, selection)?

16.01.2025 18:04 — 👍 0    🔁 0    💬 1    📌 0

In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep.

Our paper in @nature.com today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread...

15.01.2025 21:44 — 👍 48    🔁 17    💬 7    📌 1

Manuscript logo, phylogenetic tree of mouse strains with different but highly reproducible patterns of cancer evolution. Demonstrated by rerunning cancer evolution in a controlled system.

To what extent is cancer development deterministic and predictable..?

Does the germline genome affect that predictability...?

Preprint: www.biorxiv.org/content/10.1...

15.01.2025 19:31 — 👍 15    🔁 8    💬 1    📌 0

Genetic background sets the trajectory of cancer evolution Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

🧵[1/12]

15.01.2025 19:19 — 👍 79    🔁 26    💬 8    📌 5

Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.

Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years!

"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...

15.01.2025 17:21 — 👍 23    🔁 11    💬 1    📌 1