Martin Taylor

A really interesting and insightful paper Vova.

DNA mutagenesis driven by transcription factor competition with mismatch repair Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...

IGC is looking for a Core Facility Bioinformatician to provide bioinformatics expertise and support to researchers across the Institute, working at the intersection of computational and experimental science. Find out more and apply by 13 October: edin.ac/3R5dEBU
@cmvm-edinburghuni.bsky.social

PhD Student in Mutational Processes Driving Somatic Evolution

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...

You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social

🔬Under the microscope: DNA damage tracked through cell generations🔬

It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com

rdcu.be/em0qi

@cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

Adverts with full details below ⬇️

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating...

This is just brilliant. New tool dissects immune profiles from WGS. Gives novel insights into >90k (!) tumours, highlights circulating immune changes https://buff.ly/41y6Hzz Found with researchbriefing.com

[2/2] Within a strain, that's divergence from a common starting point. The more heterogeneity (divergence) amongst tumours generated, the less the path of tumour development has been fully determined by the controlled variables.

[1/2] Throughout the paper we do talk about convergence of phenotypes between strains. For each strain the we took the same starting point (genetics, environment, sex, exposure) and asked how consistent were the tumours produced (same drivers, mutations, expression, selection)?

In science, we often see weird blips in the data. The question: is it artefact (usually!), or something new & exciting? We don’t always have time to dig deep.

Our paper in @nature.com today came from just such a blip. So don’t ignore the weird stuff. Pull on that thread...

Manuscript logo, phylogenetic tree of mouse strains with different but highly reproducible patterns of cancer evolution. Demonstrated by rerunning cancer evolution in a controlled system.

To what extent is cancer development deterministic and predictable..?

Does the germline genome affect that predictability...?

Preprint: www.biorxiv.org/content/10.1...

Genetic background sets the trajectory of cancer evolution Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

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Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.

Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years!

"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...