Open position for graduate student at the Roselli lab!

To all colleagues here: have you ever built your own hardware upgrades, and is it worth compared to buying it?

A new preprint from the lab: are there actionable entry points to treat intracranial hypertension? our investigation of a porcine subdural haematoma model: www.biorxiv.org/content/10.1...

Meningeal lymphatics-microglia axis regulates synaptic physiology Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previo…

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||

www.sciencedirect.com/science/arti...

Heading to the Mario Negri Institute in Milan! New TBI research will be presented in our talk there tomorrow!

Mechanism for treating muscle degeneration discovered Utrophin increase in muscle cells after transcriptional adaptation normalises cell function in Duchenne muscular dystrophy

New treatment avenue for #Duchenne muscular dystrophy: researchers found that transcriptional adaptation can boost utrophin production in human cells, unlocking a promising new therapeutic approach!🎉@stainierlab.bsky.social‬, Lara Falcucci, @cmdooley.bsky.social, @douglasadamoski.bsky.social et al.

Woman in cancer remission for record 19 years after CAR-T immune treatment CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.

CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach

https://go.nature.com/42XLYpK

Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.

A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...

Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1 Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volu...

We are glad to celebrate our associate Florian olde Heuvel, for the award of the Hannelore Kohl Foundation national prize for his work on biomarkers of synaptic damage in human severe TBI ! jnnp.bmj.com/content/95/1...

--- Seminar in #Neuroscience ---

Functional diversity of inhibitory amygdala microcircuits

🗣 Dr. Sabine Krabbe, DZNE, Bonn
📅 Jan 27, 2025 - 16:00
Lecture Hall, Biocenter @unicologne.bsky.social

zoologie.uni-koeln.de/forschung/ne...

@ibehave.bsky.social @ggatto.bsky.social

Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive ...

Some more recent work in preprint format (we really like preprinting everything!) : www.biorxiv.org/content/10.1...

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration Through in vitro and in vivo electrophysiology and super-resolution microscopy, Nascimento et al. identify early-stage alterations in pre-motor spinal recurrent inhibition and monosynaptic Ia excitati...

A very productive collaboration with the always-great Beato lab! www.cell.com/cell-reports...

Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study - Acta Neuropathologica Communications Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathe...

More neuropathology forays for us, and third paper with the Braaks : actaneurocomms.biomedcentral.com/articles/10....

Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia - Acta Neuropathologica Communications We quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied n = 9 cases without neur...

Forays into human neuropathology and the mistery of white-matter neurons (with the living legends Braak&delTredici): actaneurocomms.biomedcentral.com/articles/10....

Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1 Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the b...

Highlights from the last three months of RoselliLab work! Marker of synaptic damage and neuroinflammation in human severe TBI pmc.ncbi.nlm.nih.gov/articles/PMC...

Blood–CSF barrier integrity in amyotrophic lateral sclerosis The blood–CSF barrier helps to regulate inflammation in the CNS, and to shield the CNS from potentially toxic external factors. Klose et al. show that the

Blood-CSF barrier in ALS: patterns and alterations across >1000 patients
academic.oup.com/brain/articl...

Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation - Scientific Reports Scientific Reports - Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

Hypothalamic atrophy as a new imaging endophenotype in ALS: how does it change in ALS variants? www.nature.com/articles/s41...

Sub‐Microliter 1H Magnetic Resonance Spectroscopy for In Vivo High‐Spatial Resolution Metabolite Quantification in the Mouse Brain An optimized acquisition and post-processing pipeline for brain magnetic resonance spectroscopy based on the LASER sequence is reported, enabling metabolite spectra from 700 nL volume of interest in ...

A good start into 2025 for the RoselliLab. A refined MR spectroscopy pipeline for the definition of absolute metabolite concentration in the mouse brain with sub-microliter spatial resolution: onlinelibrary.wiley.com/doi/10.1111/...

Here comes the RoselliLab also on BlueSky !