SorrentinoLab

Centrosome architecture and m6A-dependent gating of p53 surveillanceafter whole-genome doubling https://www.biorxiv.org/content/10.64898/2026.02.25.707964v1

An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells Chronic liver injury triggers the ductular reaction, where biliary cells expand to repair damage but can drive disease progression when persistent. Anfuso et al. model this process ex vivo within a native microenvironment using precision-cut liver slices and uncover a metabolic vulnerability targeted by statins in experimental systems and patients.

An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells

An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells Chronic liver injury triggers the ductular reaction, where biliary cells expand to repair damage but can drive disease progression when persistent. Anfuso et al. model this process ex vivo within a na...

www.cell.com/cell-reports...

🎉 Our lab’s first paper is out in Cell Reports! We present a novel organotypic model of ductular reaction that recapitulates epithelial remodeling within a native microenvironment using precision cut liver slices. Huge thanks to AIRC for the support!⁦‪

www.mdpi.com/1424-8247/18...

Can engineered hydrogels reshape the future of biliary organoids?
Our new review explores how next-generation, fully tunable hydrogels are transforming the way we model biliary diseases in vitro.