Irene Cantone

Advice needed: can you distinguish splicing variants by commercial #spatialtranscriptomic (eg visium)? #singlecell #omics

The #Nobel prize has been assigned to the discovery of #Treg peripheral tolerance. We are humbly greatful for this discovery as we recently described a subtype of Tregs associated with worse breast cancer prognosis

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

Molecular determinants underlying functional divergence of TBP homologs The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

#Xcromosome paper on the role of the #human specific long noncoding RNA #XACT!

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression https://www.biorxiv.org/content/10.1101/2025.10.02.680155v1

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Lysosomes signal through the epigenome to regulate longevity across generations The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

Metabolism changes the epigenome across generations via lysosome Supercool! www.science.org/doi/10.1126/...

The original publications on #XIST ruled out there were ORF matching the sequence and showed accumulation of the RNA in the nucleus but are these sufficient to rule out protein coding regions? I assume if there were they should have been discovered… or not?

To the #XchromosomeInactivation field: anyone knows Xist is a long #noncodingRNA Which publication has ruled out that there are protein coding regions within it? And how?

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

The story of sex determination from a woman’s life perspective. Beautiful thread for #WomenInternationalDay

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

A #computational #Postdoc position is available in my lab to dive into #chromatin mediated #epigenetic mechanisms underlying #autoimmune reactions in #MultipleSclerosis! Please circulate

a drawing of a tree with a heart shaped trunk and two books with the letters x and y on them . ALT: a drawing of a tree with a heart shaped trunk and two books with the letters x and y on them .

FUNDED! I will be recruiting soon a computational #postdoc. If you fancy working on exceptional #singlecell #omics datasets to explore the role of #XChromosomeInactivation in the #sexdifferences of #autoimmune diseases contact me! Predoc fellows with prior experience are also invited to apply!

Happy #womenInSTEM day!

Our university has hoghlighted our recent work on #Treg and breast #cancer. Italian only www.unina.it/-/66774917-l...

Fellowships, grants and career support – Postdoctoral Fellowships – EMBO Supporting internationally mobile postdoctoral researchers in Europe and around the world

Get in touch if you are passionate for science and want to learn more about #epigenetic of sex differences in human disease www.embo.org/funding/fell...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.

These findings pave the way for novel super targeted immune therapies. Thanks to all friends and colleagues involved 6/

We demonstrate that the tumor micro environment (TME) induces FOXP3E2 via CXCL12 and these Treg subtype has higher immunosuppressive capacity 5/

FOXP3E2 high tumours were associated with defective mismatch repair stem cell-like signatures 4/

TCGA analysis of over 1000 breast cancers showed that higher FOXP3E2/FOXP3 ratio is a prognostic marker for all breast cancer subtypes

We analysed Tregs from a new cohort of hormone-positive breast cancer patients and found that FOXP3E2 Tregs are enriched in primary tumours and blood of patients with worse prognosis 2/

CD4+FOXP3Exon2+ regulatory T cell frequency predicts breast cancer prognosis and survival FOXP3E2+ Treg enrichment reflects an increased tumor-immune suppression and predicts prognosis in breast cancer.

Our first #immunology paper is out! We show that Tregs with FOXP3 splicing variants retaining exon 2 are a prognostic marker for breast cancer www.science.org/doi/10.1126/...

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused:

sciencedirect.com/science/arti...

A big thank you to Tom Fillot for his efforts on this and to
@hansen_lab

@marcelonollmann
for their help as editors.

🚨🚨🚨
Call is now open!!! Deadline approaching...
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇