Kaabir Ali

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇

Registration is open for the next Genome Dynamics course at @institutcurie.bsky.social! This course will explore the full spectrum of genome biology bringing together international experts to share the latest experimental and computational advances ▶️ training.institut-curie.org/courses/Geno...

1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

🔬 Postdoctoral Opportunity in Biomedical Research. #Organoids & #Organs-on-Chip for #IBD and #Personalized #Medicine at #i2mc in #Toulouse, #France at the crossroads of #stem cell biology, #microphysiological systems, and translational medicine.

👉 Apply before Nov. 1rst at audrey.ferrand@inserm.fr

What We Learned From 150 Episodes of the Epigenetics Podcast, An Introduction to the Series In late 2017 I pressed record on the very first episode of the Epigenetics Podcast. My goal was to speak with the field’s leading voices and uncover the stories behind their discoveries. Since then th...

In 2017 I recorded the first episode of the @epigeneticspod.bsky.social. In this article I invite you to explore highlights from 150 episodes and starting a series of Articles that summarises the key lessons I learned from those conversations. #podcast

www.activemotif.com/blog-epigene...

How can we use cell shapes and geometry to study mechanics of tissues?

I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

Visual of segmented human induced pluripotent stem cells with the key workshop dates: Symposium on November 10-11, Hackathon on November 12-14th in Zurich Switzerland

We're happy to announce the 2025 International OME-NGFF workshop 🎉

📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025

📍 Location: Zurich, Switzerland

Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up... 

#bioimaging #openscience #OMENGFF #OMEZarr

(1/x 🧵)

The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...

Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳

Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻

Enjoy the reading www.nature.com/articles/s41...

YouTube video by The Ezra Klein Show Is Israel Committing Genocide in Gaza? | The Ezra Klein Show

Vous pouvez écouter la discussion sur l'indifférence plus en détail ici. C'est le manuel qui a déjà été utilisé.

youtu.be/RrhBypHFYPY?...

Pas tout à fait! Les gens sont conscients de la situation, mais ils sont indifférents à la souffrance humaine. Lors d'un récent sondage, interrogés sur les informations faisant état de famine et de souffrances au sein de la population, la majorité des personnes interrogées n'étaient pas inquiètes.

To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.

I think the honest answer (but a sceptical one) to this question is: probably not (we can't know right now). But I can answer two other questions. (1) Is Avi Loeb's late alien work serious and honest? NO. (2) Is this damaging science when Loeb uses his authority as a Harvard academic? YES.

The front page of Le Monde newspaper today.

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos?

I’m @amichaut.bsky.social, and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

BREAKING: Zeteo has released, globally, the film the BBC so controversially refused to air.

"Gaza: Doctors Under Attack" is now available to watch in full at gazadoctors.film and zeteo.com.

Here's the trailer:

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1
www.nature.com/articles/s41...

Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion i...

Boom!!! 💥💥💥💥
EpiSci - 🧬 - 🧪 - Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
@Zachary D. Chiang. @Ajay S.Labade @jbuenrostro.bsky.social

www.science.org/doi/10.1126/...

A man smiles at a lectern, talking towards a room. Behind him, a PowerPoint screen is shown with a blue background and the words 'AlphaFold Education Summit. 14 – 16 January 2025. Hinxton, United Kingdom. The EMBL's European Bioinformatics Institute and Google DeepMind logos are also shown on screen.

Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase and strengthen global capacity through train-the-trainer sessions & the co-development of further #AlphaFold training.

Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat...
🧪🖥️🧬

Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

Genetically encoded reporters of actin filament organization in living cells and tissues Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...

Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...

🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !

A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌

🧵⤵️

Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes...

I think the link was broken
elifesciences.org/articles/99149

A tension-induced morphological transition shapes the avian extra-embryonic territory Michaut et al. show that the tension produced during epiboly elastically stretches the extra-embryonic (EE) territory, while the embryo proper (EP) remains unaffected. Although the whole epiblast (EP ...

I am delighted to share with you my first postdoc paper, which has now been published in @currentbiology.bsky.social!
www.cell.com/current-biol...
Thanks to everyone who contributed: A. Chamolly, @aurelienvilledieu.bsky.social, F. Corson and @jeromegros.bsky.

A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

Measuring and manipulating mechanical forces during development - Nature Cell Biology This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !

Great one-day meeting on #cancer #mechanobiology in Paris (March 14th).

Getting tissue stress from images is tough, and elastic tension sensors are a way to solve this. Still, the analysis is complex. Try our GUI gitlab.gwdg.de/betzlab_publ... implementing analytical solutions to obtain surface stresses AND shape parameters of beads and nuclei.

New collection from @jcb.org examines the mechanical properties and interactions that shape the fundamental operations and structures of cells. Delve into diverse mechanical properties of membranes, organelles and other structures within & among cells 👉 https://buff.ly/3EK0uaq