Philipp Zimmer

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns | Neurology Neuroimmunology & Neuroinflammation Background and ObjectivesKynurenine pathway (KP) metabolites modulate inflammatory activity and neuronal viability. The consequences of KP imbalance partly resemble the molecular mechanisms of multipl...

In this fantastic collaborative project with colleagues from Norway, @tu-dortmund.bsky.social @au.dk @uni-saarland.de, our outstanding PhD student @mkupjetz.bsky.social has shed light on distinct kynurenine pathway patterns in persons with #multiplesclerosis.

www.neurology.org/doi/10.1212/...

YouTube video by TU Dortmund Research Snapshots: Sportimmunologie

Welchen Einfluss hat Sport auf unsere Gesundheit? Lassen sich Immunzellen durch gezieltes Training beeinflussen? Kann man Sport sogar MS-Patienten Linderung verschaffen? Daran forschen Prof. Philipp Zimmer vom Institut für Sport und Sportwissenschaft & sein Team. www.youtube.com/watch?v=h58Y...

@agingdoc.bsky.social something for you;)

Exercise training restores longevity‐associated tryptophan metabolite 3‐hydroxyanthranilic acid levels in middle‐aged adults Aim Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated ...

Check out our new paper now out in Acta Physiologica on the tryptophan metabolite 3-HAA in the aging and exercise context 👇
@50823zimmer.bsky.social @davidwalzik.bsky.social

onlinelibrary.wiley.com/doi/full/10....

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

Acute exercise rewires the proteomic landscape of human immune cells Exercise-driven alterations of the immune system are a key mechanism in the prevention and treatment of various diseases. Here, we performed mass spectrometry-based proteomics analysis on peripheral b...

Happy to share our new preprint, where we investigate the impact of acute exercise on the proteome of immune cell! Comparing high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), we found numerous proteins that were differentially expressed in PBMCs. (1/12)

Acute exercise rewires the proteomic landscape of human immune cells https://www.medrxiv.org/content/10.1101/2025.01.30.25321196v1

Over 100 German Universities Partner with MDPI in New National Agreement More than 100 German universities and research institutions have entered into a national agreement with MDPI. The publication agreement negotiated...

While first countries blacklisted MDPI for their unserious and harmful publishing culture, German universities signed contracts with this china hosted predator publisher…what a waste of tax payer money!

www.mdpi.com/about/announ...

And there is this.... bsky.app/profile/carl...

Scientific publishing cannot be free but an annual $2.5 billion seems excessive to me

The strain on scientific publishing Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...

Finding the right journal is crucial and may influence careers! Of note first countries have blacklisted some publishers. A must read for all PIs, Post Docs and PhD Students:

direct.mit.edu/qss/article/...

Unbelievable to see our second @BrainBehavImm paper out in 2024🍾 @S_Proschinger @SergenBelen @maritschlagheck @TU_Dortmund and @SpohoKoeln 💪 Here we show that multimodal exercise training provokes Natalizumab-like effects in MS:
sciencedirect.com/science/articl…

I fully agree that null results are equally important and should be published. Still do not see any reason to support MDPI and Frontiers…neither with money, nor intellectual input as reviewer or author…In the end they undermine the integrity of our labs, PhDs, etc.

Is MDPI a predatory publisher? Edit April 20th, 2021: thanks to Christos Petrou I found a bug in my code. I was considering both “Section” and “Collection” articles as Speical Issue. The whole analysis ha…

paolocrosetto.wordpress.com/2021/04/12/i...

Impossible😂 But why the hell submitting there??? Publishing in MDPI may be the best way to kill a PhD students career before it even started:

predatoryreports.org/news/f/list-...

t.co/1NaeJXfSwx

How does exercise exert preventive and therapeutic effects in different diseases? What is the molecular basis of these effects and how are exercise signals mediated on a cellular level? A 🧵on our lates review in Signal Transduction and Targeted Therapy:
(1/13)

Thanks a lot to @50823zimmer.bsky.social and @niklasjoisten.bsky.social for the great supervision and input along the way and to Tiffany for the endless hours discussing mechanistic details! Cheers!🥂 (13/13)

As always this project would not have been possible without the help of numerous collaborators. A special thanks to @50823zimmer.bsky.social , Alan Metcalfe and @niklasjoisten.bsky.social who planned and conducted the trials and to Alexander Schenk, who performed hundreds of PCRs. (12/13)

6/ Writing or reviewing a manuscript? Watch out for these ten common statistical mistakes 👇
https://elifesciences.org/articles/48175?utm_source=bluesky&utm_medium=social&utm_campaign=organic

Recently, I have been on a grant review panel and a few members judged applications by the PI’s H index and impact factor of the previous papers - I objected. What has that to do with the strength of the proposed project?