(3/3) We conclude by examining various design principles used to engineer condensates in cells and in vitro, highlighting both tested and potential enzyme-hosting condensates. We finish with an outlook in which we envision the future of the field.
08.04.2025 09:27 — 👍 0 🔁 0 💬 0 📌 0
(2/3) These principles also influence enzymatic cascade reactions. Condensates offer possibilities for substrate channeling, hierarchical structures, and communication between condensates. The size of substrates also plays a significant role in enzymatic dynamics.
08.04.2025 09:27 — 👍 2 🔁 0 💬 1 📌 0
(1/3) This review focuses on the role of small molecular metabolites within condensates, with an example case study on glycolysis. We then explore how condensates affect single enzymatic reactions through the chemical environment, mass action, protein stability, scaffolding, and diffusion.
08.04.2025 09:27 — 👍 0 🔁 0 💬 1 📌 0
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Biomolecular condensates are membrane-less compartments found through-out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying...
🚀Excited to share our latest review in Adv Biol!
Discover how biomolecular condensates enhance biochemical processes and their potential in biotech.
Shout out to Nikita, Ankush, and Magnus for making this possible.🌟
doi.org/10.1002/adbi...
@proteinmagnus.bsky.social & @nikitarehnberg.bsky.social
08.04.2025 09:27 — 👍 3 🔁 0 💬 1 📌 1
Huge thanks to Magnus Kjærgaard for his invaluable guidance in writing this proposal, my PhD supervisor Evan Spruijt @spruijtlab.bsky.social for his mentorship, and my (former) colleagues Maria, Ankush, Tiemei, & Karina for sharing great examples and support!
Excited for the journey ahead! 🚀🔬
25.02.2025 09:44 — 👍 2 🔁 0 💬 0 📌 0
After just a year transitioning from Radboud University to Aarhus University, I’m excited to continue exploring my interest in coacervates, aiming to design Synthetic Programmable Artificial Condensates for Enzymatic Reactions - gaining insights into metabolic engineering & synthetic biology
25.02.2025 09:44 — 👍 2 🔁 0 💬 1 📌 0
🌟 Exciting News! 🌟
I’m thrilled to share that I’ve been awarded the Marie Skłodowska-Curie Postdoctoral Fellowship for my project SPACER at @molbiolau.bsky.social with @proteinmagnus.bsky.social ! 🎉
#MarieCurieFellowship #BiomolecularCondensates #SyntheticBiology #MSCA #Coacervates
25.02.2025 09:44 — 👍 6 🔁 0 💬 1 📌 1
Auteur van De Zijkant van de Macht | Eigenaar Julia Wouters Leading Women | FD Columnist | Podcast De Spindoctors | www.juliawouters.nl |
De novo evolved proteins. @bornberglab.bsky.social. he/him.
bornberglab.org/people/eicholt/
Scientist and educator. PostDoc investigating spaghetti proteins and reactions within. Enthusiast of microbes (al. B. (it) subtilily), intrinsic disorder and rheology of cats #IDRs #cats #EDI 🏳️🌈
Welcome to the UK Physics of Life network, a vibrant, community-driven collaboration of scientists from the physical and life sciences. For more information, visit our webpage: https://www.physicsoflife.org.uk/
Assistant professor at Radboud University.
Interested in everything chromatin, from single-molecule biophysics to cell biology.
www.eeftenslab.com
Biophotonics, Biophysics & Innovation
@KITkarlsruhe
Lorenzo Di Michele's research group at @cebcambridge.bsky.social University of Cambridge (and also a bit at Imperial College). Working on DNA/RNA nanotechnology and Synthetic Cells
Group leader @embl.org European Molecular Biology Laboratory
#RNA biology | #single-molecule #biophysics | #structural biology | #biochemistry | #quantitative biology | #chemical biology | #synthetic biology - https://www.embl.org/groups/duss/
Schraderlab.org - Enjoying all things related to RNA, RNPs, biomolecular condensates, and bacteriology. Rebuilding our lab at IU in 2025.
Scientist by day (drummondlab.org), artist by night (dadrummond.art). Sculpture, drawings, and other works. Obsessed with the details of the natural world. Lab posts at @drummondlab.bsky.social 🧪
TLM is an initiative to build a network for researchers interested in theory and modelling of biological phenomena. We are on X (old twitter) @TLM_Cambridge, @TLM_Cambridge@mstdn.science. Or follow our website for more details: tlmcambridge.blog
Astrobiology is an exciting interdisciplinary field about the origins, evolution and distribution of life in the universe. We are based at the University of Arizona in Tucson, AZ.
Scientists using microscopes, math, physics and fun to discover how cells work @Duke Cell Biology/BME. https://gladfelterlab.net
I am a Cori Fellow at WashU Medical School. We study how IDRs help keep time while contributing plasticity and robustness to the circadian clock. She/Her opinions are my own.
www.jackiepelhamphd.com
Organic chemist interested in the origins of life. Moranlab.com
🇨🇦 CRC1 and Prof @uottawa.ca
🇫🇷 part-time @unistra.fr
Physics PhD candidate @umontreal.ca.
Visiting scholar at ASU Biodesign Mathis Group.
Complexity, information theory & origins of life.
https://alexandrechampagne.io
Also maintains the OoL digest: https://buttondown.com/ooldigest
International network of early-career researchers on the origin of life. Join us and subscribe to our newsletter: http://eepurl.com/iCsDR2
Assistant Prof. University of Birmingham School of Chemistry. Systems Chemistry, Physical Organic Chemistry and Soft Matter
https://www.maguire-research-group.com/
