Ary Shalizi's Avatar

Ary Shalizi

@unsequenced.bsky.social

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

144 Followers  |  178 Following  |  699 Posts  |  Joined: 12.11.2024  |  1.9146

Latest posts by unsequenced.bsky.social on Bluesky

A linkedin post from a Stanford AI researcher describing using generative AI to come up with "alternatives" to a big mac that discovers people prefer homemade hamburgers to mcdonalds hamburgers, and that portobello burgers and bean burgers can, in fact, be tasty an nutritious.

A linkedin post from a Stanford AI researcher describing using generative AI to come up with "alternatives" to a big mac that discovers people prefer homemade hamburgers to mcdonalds hamburgers, and that portobello burgers and bean burgers can, in fact, be tasty an nutritious.

In a double whammy, generative AI solves both nutrition and sustainability crises by discovering that people prefer homemade burgers to big macs AND that portobello or bean burgers can be delicious while having a smaller environmental footprint than beef?

NO WAY.

06.02.2026 05:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I get that the Superbowl is a high profile event, but having two Coast Guard speedboats with bow-mounted machine guns escort every Marin-SF commuter ferry seems like the definition of security theater?

05.02.2026 19:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I love this. I have a reminder set for when Colossal should be announcing an elephant pregnant with a mammoth...

30.01.2026 00:47 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

the synthesis of red and blue?

28.01.2026 20:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

2026 book thread, pt. 2.

Wherein I read my older daughter's favorite books series, and learn that it's pretty fun.

πŸ’™πŸ“š

25.01.2026 05:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

As a biologist who grew up in the shadow of an older brother who is physicist, this is the burn I wish I'd had handy in our school days.

22.01.2026 01:18 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Books You’ve Always Pretended to Have Read and Now It’s Time to Sit Down and Really Read Them My first review of this year is actually of the last book I finished last year. A book that’s been on my to-be-read pile since 2006, but that I wasn’t ready for until 2025.

Here's a 2026 books thread.

First review this year is one I'm surprised doesn't get referenced more often by critics of genAI. It even talks about the "electronic production of homogenized literary works," which is remarkably on the nose for something published more than four decades ago...

πŸ’™πŸ“š

16.01.2026 03:06 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Works ok for me if the books are different enough (e.g., one fiction and one non-fiction, or two different non-fiction genres like history and pop sci), but can't do two of the same type at the same time without getting confused...

13.01.2026 18:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Cannot possibly be accurate.

03.01.2026 23:27 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

disappointing.

03.01.2026 05:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Did that reporter ever get back to you with an explanation? I am so curious!

02.01.2026 20:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hey #booksky, this year I got myself off of Audible in favor of Libro, Libby, and Hoopla. I tried leaving GoodReads, but never really came around to StoryGraph. Has anyone tried Bookwyrm, or Bookworm, or know of other reading trackers they enjoy? Or should I give the StoryGraph another go in 2026?

31.12.2025 05:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

To be fair, Rodriques IS a scientist (PhD with Ed Boyden at MIT, did solid doctoral work, and was faculty at the Crick before starting Future House), but he is also a True Believer.

31.12.2025 00:16 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I’ve been reading a lot of what I can only describe as β€œbiotech evangelism” over the last few years, and I’ve noticed that β€œtheoretically possible” is usually conflated with β€œpractically inevitable,” even by accomplished researchers…

30.12.2025 22:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

It’s that #vibephysics we’ve been hearing so much about.

29.12.2025 16:08 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Join now, and your home also receives a discount code from the ever loyal and true security experts at Boromir Protective Services, LLC.

29.12.2025 15:36 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I wouldn’t call the people scooped up by Operation Paperclip β€œrefugees.” It was more β€œwe need to collect them before the Soviets do, war crimes be damned.”

29.12.2025 14:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

OTOH, first to the Moon thanks to importing a bunch of barely reformed Nazis from Pennemunde…

29.12.2025 14:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Digging for Utopia | Kwame Anthony Appiah That the history of our species came in stages was an idea that came in stages. Aristotle saw the formation of political entities as a tripartite process:
29.12.2025 05:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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β€˜Wrong About (Almost) Everything’ – a review of β€˜The Dawn of Everything’ by David Graeber & David Wengrow 'The Dawn of Everything: A New History of Humanity', David Graeber and David Wengrow (2021) - reviewed by Chris Knight.
29.12.2025 05:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Against Method The Dawn of Everything: A New History of Humanity, by David Graeber and David Wengrow. New York: Farrar, Straus and Giroux 2021. Pp. 704. $35. ISBN 9780374157357 (paper). | American Jou...

DoE has problems of its own…

(It’s intellectually provocative and well researched, but as Henry Farrell puts it, probably best considered as β€œspeculative non-fiction.”)

29.12.2025 05:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

The economist Jeff Sachs would be another example. Definitely not right wing, but super into the lab leak idea.

29.12.2025 02:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0

I don’t know, there’s a certain class of centrist who believes intelligence reports are superior to scientific evidence (eg, the former obama national security staffer and author Jaime Metzl), and Stewart is one of those.

29.12.2025 02:12 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Know the differences between the various tools, they just find β€œAI” a useful general label.

29.12.2025 02:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

And unfortunately ARE referred to as AI by practitioners using them. I am a cell/molecular biologist, and have computational biologist colleagues who refer to all kinds of AI tools in exactly the kind of undifferentiated way critics find so problematic. These are sophisticated professionals who

29.12.2025 02:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Ok, but what about systems that propose de novo proteins, a la David Baker’s work? That is also considered generative AI, and a class of language model. Or the use of LLMs for annotating large sequencing datasets, often done with tools like GPT-4? Even the β€œbad” tools have narrow use cases,

29.12.2025 02:01 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Had to stop listening to him once he went full lab leak…

28.12.2025 21:17 β€” πŸ‘ 13    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
Older man with two girls looking through window to design studio where he studied six decades earlier

Older man with two girls looking through window to design studio where he studied six decades earlier

Man shows stream on Berkeley campus to his granddaughter while reminiscing about his time as a student radical.

Man shows stream on Berkeley campus to his granddaughter while reminiscing about his time as a student radical.

My father’s first visit to CA since the girls were born, showing his grandkids around the Berkeley campus.

β€œI think those are the same tables they had when I was studying architecture.”

β€œYes, we ran down to that stream after Reagan ordered the soldiers to teargas the protestors.”

28.12.2025 21:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Oh, and @annaleen.bsky.social and @charliejane.bsky.social have a great podcast about the intersection of pop culture and tech, but you’re probably aware of that already.

28.12.2025 16:14 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I think @adambecker.bsky.social does a great job of exploring the cultural influences on the same iteration of Silicon Valley that Daub discusses, and if Disney was an influence, I don’t think any of the tech titans are going to admit to that…

28.12.2025 16:08 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@unsequenced is following 19 prominent accounts