Ary Shalizi's Avatar

Ary Shalizi

@unsequenced.bsky.social

Biologist, book nerd, parent, hype skeptic in no particular order. Phenotypic screening for cell and chemical biology. Also, random book reviews at link. unsequenced.life

130 Followers  |  160 Following  |  552 Posts  |  Joined: 12.11.2024  |  2.3381

Latest posts by unsequenced.bsky.social on Bluesky

When I TA’d intro neurobiology I always enjoyed dropping the fact that skin and brain derive from the same layer of the embryo, but this is taking that trivia to some next level weird.

14.11.2025 05:50 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Going to try this approach next time I coach my daughter’s team.

14.11.2025 05:00 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If memory serves, Trivers was married to at least one Jamaican woman, and did fieldwork on Jamaican lizards?

14.11.2025 01:10 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I think it was the great philosopher Skeletor who said β€œPunishable by fine means legal for a price.”

13.11.2025 20:49 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

And β€œan LLM remixed and regurgitated famous scientists at me” makes a mockery of the concept of mentoring and advising.

12.11.2025 03:14 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I dunno, I am making fun of it because all three named individuals wrote books that can reasonably be construed as falling in the β€œadvice or mentoring” category, and you know, you could just read those and come up with your own thoughts? The LLM is some unnecessary intermediation.

12.11.2025 03:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Tell me you’re too lazy to read, and think very little of your colleagues, without saying β€œI’m too lazy to read, and think very little of my colleagues.”

12.11.2025 00:50 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Wait, which Jon Favreau?

11.11.2025 02:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 1

It's truly an evergreen idea...

This proposal is short and manages to get biology so, so wrong.

Keeping some cells and biometric data isn't "backing up" a person, any more than keeping a recipe, some tasting notes, and a slice in the freezer, is "backing up" a cake.

10.11.2025 18:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
2025 High-Content Imaging Symposium Join our 2025 High-Content Imaging Symposium, showcasing our latest innovations in high-content imaging and analysis!

Curious about how scientists at Bay Area universities and biotech companies are using high-content imaging to better understand health and disease? Join me at the @revvity.bsky.social High-Content Imaging Symposium on 11/12 at The Hangar in South San Francisco.

Details at the link!

10.11.2025 15:18 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
10.11.2025 02:56 β€” πŸ‘ 109    πŸ” 34    πŸ’¬ 2    πŸ“Œ 0

It really feels like there were obvious, relatable ways to drum up support for continuing the shutdown.

10.11.2025 03:28 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I remember seeing Watson talk as a postbac at the NIH. I’ll never forget him saying how β€œstupid” the triplet code was, compared to the hypothetical codes other people proposed, and that it was deciphered by l β€œinelegant, brute-force methods.”

Marshall Nirenberg was sitting in the front row.

08.11.2025 16:08 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 1
Post image

Text I received from a former labmate last night. Roughly sums up the vibe among molecular biologists I know.

08.11.2025 16:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Jeff Goldblum plays JD Watson! One of my grad school roommates had it on VHS.

08.11.2025 15:56 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Wife once asked our 10yo if she would be interested in taking an improv class:

Daughter: β€œNo thanks.”

Mom: β€œWell, do you know what improv is?”

Daughter, narrowing her eyes for emphasis: β€œYes AND, I don’t want to take the class.”

02.11.2025 20:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

despite spending all this money” feels like a super simplistic framing that elides a lot of other contingent factors.

02.11.2025 02:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Fair enough.I was thinking more of the fact that African countries have had comparatively more exploitative relationships with donor countries than, say, pacific rim nations (Malaysia, Thailand, Korea) that also received substantial development aid. My point is more that β€œno progress was made

02.11.2025 02:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

If we spent a trillion on cigarettes, we’d really constrain the space of diseases we needed to work on…

01.11.2025 23:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I’m curious as to which examples she uses? My father was a development economist (overlapped with both Sachs and Moyo at the World Bank), and my impression is that the relationship between development spending and poverty reduction is contingent on a lot more than just β€œwe gave this many dollars.”

01.11.2025 23:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

It’s possible Africa would be worse off if it was still a playground for extractive industries AND received no development aid.

Also, it feels a bit like saying β€œwe spent nearly a trillion dollars on the NIH in the last 30 yeara, but we haven’t ended disease.”

01.11.2025 22:47 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0

Can she provide a counterfactual? Like β€œhere’s a group of countries that received no development aid, and is doing great?”

01.11.2025 22:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

Are you a time traveler?! I haven’t even finished October!!

01.11.2025 00:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I initially read the title as β€œDon of the Dead”, and mentally swapped in a cadaverous Richard Dawkins in the thumbnail…

31.10.2025 05:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

As a scientist, I am immensely pleased that my 8yo says β€œdad, I have a hypothesis about the next Kpop Demon Hunters movie”, and not β€œdad, I have a theory about the next Kpop Demon Hunters movie.”

31.10.2025 03:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Yeah, that was the point.

26.10.2025 17:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

β€œCorrect” word meaning, or β€œmutually agreed upon” meaning?

25.10.2025 18:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Came to say the same thing.

25.10.2025 05:50 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Man, whenever tech bros wax speculative about the latest work in biology, I really want to bring them to the lab to see how hard most things are to do, and how poorly any of it scales.

24.10.2025 19:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Could have reasonably followed up with something about Buddhism, coming from nothing and going to nothing, maybe some Bhagavad Gita for good measure?

23.10.2025 01:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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