Trompouki lab Ircan Nice France

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation This study reveals that composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs.

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation: Cell www.cell.com/cell/fulltex...

Thank you Matthias!!!

Congratulations!!!!

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses, inclu...

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy: Cell www.cell.com/cell/fulltex...

A nucleosome switch primes hepatitis B virus infection A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...

www.cell.com/cell/abstrac...

Multiscale footprints reveal the organization of cis-regulatory elements - Nature We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

www.nature.com/articles/s41...

A new hypothesis to explain disease dominance The onset and progression of dominant diseases are thought to result from haploinsufficiency or dominant negative effects. Here, we propose transcript…

www.sciencedirect.com/science/arti...

Monoallelic expression can govern penetrance of inborn errors of immunity - Nature Somatically determined preferential allelic expression of select genes that when mutated cause inborn errors of immunity corresponds with disease phenotypes, suggesting that the penetrance and express...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing Down-regulation of BCL11A protein reverses the fetal (HbF, α2γ2) to adult (HbA, α2β2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo ...

A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing

doi.org/10.1126/scie...