Aurélien Doucet

Aedes albopictus (asian tiger mosquito)

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes Group II Introns (G2Is) are large self-splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2,...

Have you ever wanted to design large and complex ribozymes from scratch? I know I have!

We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!

#intron #RNAsky #SynBio 🧬🧵(1/n)

Congrats Paula !!!

🌊 Tout le mois de juin, dans le cadre de l'Année de la Mer et en marge de l' #UNOC3, retrouvez la très belle exposition du @cnrs.fr "L'océan si fort et si fragile" sur la Promenade de l'Octroi à Villefranche-sur-Mer !

Les experts décryptent ce monde bleu, clé de l’équilibre de notre planète 🌎

Ce 22 mai, le campus Valrose d’Université Côte d’Azur a accueilli plus de 500 élèves issus de 25 classes de collèges et lycées pour la grande restitution de fin d’année des projets scolaires "Science et Société".
Une journée placée sous le signe de la curiosité scientifique et de la créativité !

Our paper is now published in its final form: rdcu.be/elV6u @biomedcentral.bsky.social @salehlabparis.bsky.social @merklinglab.bsky.social @pasteur.fr

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Celebrating DNA Day with transposable elements Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...

go.nature.com/3S27sLp

Interested in the analysis on Transposable elements? 🧬
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social

We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.

www.physalia-courses.org/courses-work...

Hoping for a gig on the Cote d'Azur in 2026 !!! Many ladies of a certain age are waiting for you !!!

Fantastic talk by @aktast.bsky.social unraveling how RNA binding proteins tame the TE transcriptome, control their exonization and allow for the peaceful co-existence of TE and host genes.
LOVE IT. #TECSHA

Great talk by @emiliebrasset.bsky.social at #TECSHA on the regulation of piRNA production in germline vs somatic compartments of Drosophila ovary. Sophisticated mechanisms have evolved to control different sets of TEs, to the benefit (I think) of both host and TEs.

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

Un scientifique utilise la chimie pour créer des œuvres d'art visuelles époustouflantes. En combinant différents éléments et réactions chimiques, il produit des images fascinantes dans une goutte d'eau 💧!

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide Nature Structural & Molecular Biology - Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA...

Our study with Anjana Rao's lab was just published at NSMB 🥳 Shows how OGT prevents TET proteins from activating retrotransposons, particularly those in heterochromatin. Paper has 6-base and ONT sequencing data from OGT iKO mESCs, and also interesting OGT inhibitor data 👀.

rdcu.be/efuho

Le mot du mois #Recherche 📚
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs

@insermpacacorse.bsky.social

Hi! Here is a PhD opportunity at Montpellier, IGH institute with Séverine Chambeyron to study endogenous retroviruses ! #TEsky #PhD

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2

Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...

🧑‍🔬 Moins de bruit, plus de Science !

Tous les 15 jours, explorez la science autrement avec nos chefs de rubrique @bentonson.bsky.social et Elsa Couderc : découvertes inédites, nouvelles voix, décryptages exclusifs et bien plus encore.

⭐️ Abonnez-vous gratuitement : urlr.me/bnsS7G

Une nouvelle cible pour lutter contre les maladies chroniques liées au vieillissement Le vieillissement entraîne une accumulation de cellules sénescentes qui échappent au système immunitaire et contribuent à des maladies chroniques telles que l

#RésultatScientifique🔎 | Vieillissement : un bouclier levé ?

@juliencherfils.bsky.social et ses collaborateurs ont découvert comment un glycolipide protège les cellules sénescentes du système immunitaire. En le ciblant, ils parviennent à réduire les effets du vieillissement chez la souris ! 🧪

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Here, we demonstrate that Starships, a newly discovered group of cargo-mobilizing transposable elements, are active vectors of horizontally transferred DNA among eukaryotic species.

Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch

Université Côte d'Azur s’associe à l'initiative @standupforscifr.bsky.social au sein de l'alliance @udice.bsky.social pour dénoncer les menaces pesant sur la science et la recherche.

Mobilisation 7/03 à 13h sur le campus Valrose

Le communiqué : swll.to/StandForScie...

#StandUpForScience

Place Jussieu at 1:30PM on Friday for the Parisians! @standupforscifr.bsky.social @sufs-paris-rp.bsky.social

📲 Vendredi 28 février 2025 de 14h à 21h, SCIENCE AZUR propose un événement en ligne "DM une scientifique : échange par tchat avec une scientifique" pour inspirer les jeunes à envisager des carrières scientifiques et à promouvoir la place des femmes dans ce domaine.

RDV ici : lnkd.in/ej23CBG3

The mobile genome: genetic and physiological impacts of transposable elements

Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

We are recruiting an enthusiastic engineer to identify isoform-splicing regulation in the developing Drosophila embryo with transcriptomics & genetics in our lively team in @igmm-montpel.bsky.social
Please reshare! #jobOffer #RNA #hox #Drosophila #Nanopore #splicing
emploi.cnrs.fr/Offres/CDD/U...