Improving Oversight of Federal Grantmaking By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

This is literally some of the craziest shit I have ever read.

And that's saying a lot.

www.whitehouse.gov/presidential...

Senator Murray Opening Remarks at Full Committee Mark Up of Defense and Labor, Health and Human Services, and Education Bills | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

Some good news. NIH budget to get $400M bump not the 40% cut requested. Hopefully not just ignored ... www.appropriations.senate.gov/news/minorit...

A Quiet Policy Shift That Could Devastate American Science Why NIH’s sudden move to multi-year grant funding should alarm every principal investigator and university

A little known - but hugely consequential - part of the government’s changes to science funding:

open.substack.com/pub/sciencea...

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan - PubMed Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is u...

Thank you! It's been a fun project for sure. Have enjoyed your work on ribosome heterogeneity and aging as well! pubmed.ncbi.nlm.nih.gov/25635753/, pubmed.ncbi.nlm.nih.gov/33289480/

This work was spearheaded by M. Hafiz Rothi, Gautam Sarkar and Joseph Alhaddad who were helped by Wayne Mitchell, @kejunying.bsky.social, Nancy Pohl, Roberto Mena, Julia Natale, Scarlett Dellacono, and @gladyshev.bsky.social. Thanks to all the authors! 8/8

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span - PubMed During C. elegans development, animals must choose between reproductive growth or dauer diapause in response to sensory cues. Insulin/IGF-I and TGF-beta signaling converge on the orphan nuclear recept...

DAF-9 was previously shown by @antebilab.bsky.social to produce the signaling lipid dafachronic acid to signal from the germline to the soma to regulate lifespan. pubmed.ncbi.nlm.nih.gov/11740945/ pubmed.ncbi.nlm.nih.gov/17360327/ . dimt-1 induced lifespan extension was dependent on this pathway 7/8

We also found that DIMT-1 regulates selective translation of stress resistance and lifespan regulating transcripts in the worm's germline but not in the muscle. One transcript which we identified as displaying differential ribosome occupancy was the cytochrome P450 enzyme DAF-9. 6/8

We found that dimt-1 deficiency requires the TOR signaling pathway and an intact germline to extend lifespan. Using auxin-inducible degron tagged dimt-1 and tissue specific RNAi we found DIMT-1 functions in the worms' germline after mid-life to regulate organismal lifespan 5/8

18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis - PubMed Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific non-genetic cues are transmitted from parents to their descendants are poorly understood. Here, w...

An RNAi screen identified that dimt-1 KD caused lifespan extension. We had previously shown that DIMT-1 is an 18S rRNA m62A methylase and that methylated rRNAs are transmitted to subsequent generations to drive intergenerational response to starvation pubmed.ncbi.nlm.nih.gov/37689068/ 4/8

We found that DIMT-1 functions in the germline and works after mid-life to extend lifespan. This reveals a new layer of regulation of lifespan, which transcripts are selectively translated, and found that ribosome heterogeneity is critical later in life to promote healthy aging. 3/8

As we age there is a dysregulation of which proteins are degraded and which proteins are produced. We showed that DIMT-1 methylation of the ribosome selectively regulates the production of stress resistance and longevity regulating proteins and regulates aging. 2/8

The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life - PubMed Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknow...

Excited to see our manuscript out @natcomms.nature.com pubmed.ncbi.nlm.nih.gov/40721431/. We identified that the 18S rRNA methylase DIMT-1 regulates lifespan by functioning in the germline after midlife. 1/8

My lab name is EZE. Was nicknamed easy-E cause I like rap and am relatively easy going.

I was born in the McCarthy era, but this is McCarthyism on steroids.

Our democracy is under dire threat. But we have a government of laws, not men. And NO ONE is above the law.

Congratulations! Looking forward to reading it.

New Academy Members Elected in 2025

Congratulations to Anne @brunetlab.bsky.social for being elected to the AAAS www.amacad.org/new-members-...! And congratulations to all the other new members

Congratulations. Looking forward to reading it!

Chromatin and epigenetics in aging biology Abstract. This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are dec

New WormBook Chapter: Chromatin and epigenetics in aging biology

academic.oup.com/genetics/adv...

Don't become Vichy France

Last week, House Democrats opposed giving Elon Musk and Trump a blank check funding bill that would allow them to gut programs and services families rely on.

The Senate must pass a short-term spending bill so we can pass bipartisan bills that protect programs for our communities.

Senate Democrats if you need a playbook for how to vote, simply look to what Mitch McConnell did when Barack Obama was proposing very centrist legislation. You are the opposition party now, act like it!
@schumer.senate.gov @democrats.senate.gov

They literally just told everyone in the dept of education to not come to work!!! They are already doing this!!!

KEEP CALLING. PEEL OFF ALL DEM SENATORS YOU CAN.

☎️: (202) 224-3121

Tell them to vote NO on Cloture and NO on CR. Vote is pushed to after 1:15ish for now. Situation is fluid.

The only public YES votes are Schumer and Fetterman. They need 7-8 total. KEEP CALLING.

Call retiring Senators too!

CALLS ARE WORKING - it has bought us precious time, but we NEED to keep the pressure up.

Tomorrow is the cloture vote.

KEEP CALLING: (202) 224-3121 ☎️☎️☎️

Tell your Dem Senator to vote NO on Cloture and NO on the Republican spending bill.

Do NOT assume your Senator will be good on this. Trust me.

Donna Lieberman, @dlnyclu.bsky.social Executive Director of the New York Civil Liberties Union @nyclu.org on Mahmoud Khalil: "There is not a hint of a claim that he did any of those things. The idea that he should be deported is illegal, wrong, and reeks of McCarthyism."

18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis - PubMed Heritable non-genetic information can regulate a variety of complex phenotypes. However, what specific non-genetic cues are transmitted from parents to their descendants are poorly understood. Here, w...

We actually had a paper on that in case you're interested!
pubmed.ncbi.nlm.nih.gov/37689068/

YouTube video by rutaloot Woody Guthrie- This Land Is Your Land

Healthcare is our right,
For which we must fight.
Our vision's global
Our cause is noble.
It's our insistence-
Join the resistance!
Science is good for you and me.

7/7

#standupforscience

www.youtube.com/watch?v=wxiM...

You huddled masses-
Come take our classes.
If you are yearning-
Come here for learning.
And after college-
Please share your knowledge.
Science is good for you and me.

6/7

Don't de-fund science-
Join our alliance!
New forms of energy-
It's time for synergy.
To protect our planet,
Science- don't ban it!!!
Science is good for you and me.

5/7

For global warming,
The facts come swarming.
Climate denial-
It's suicidal!
You might deny it-
We just don't buy it.
Science is good for you and me.

4/7