Yaroslav Sych

Very useful work for the community that study neuromodulation!

Separating cognitive and motor processes in the behaving mouse Nature Neuroscience - Using a novel method for isolating cognitive and motor neural dynamics, the authors show that dynamics often attributed to cognitive processes were corrupted by movements and...

Really proud and excited to share the final version of our paper, co-led by the Bluesky-less Munib Hasnain!!

We asked whether cognitive and motor neural dynamics can be isolated from one another, or whether they’re driven by common neural mechanisms 1/n

www.nature.com/articles/s41...

Hi, what did you use for extracellular matrix and why does it seem to be localized to L2/3?

A distinct hypothalamus–habenula circuit governs risk preference Nature Neuroscience - Groos et al. show that lateral habenula activity reflects individual risk preference before action selection. This activity is modulated by behavior-relevant synaptic input...

The #habenula in our brain tells us about the negative consequences of our actions, helping us avoid risky behaviors and problems with #addiction. My colleagues found neural pathways to the habenula that promoted consistency in the behavior of mice making risky or safe choices.

rdcu.be/d7g8d

Recurrent models of orientation selectivity enable robust early-vision processing in mixed-signal neuromorphic hardware Nature Communications - The authors present characterisations of highly-structured visual receptive fields of any phase symmetry, implemented in an event-based spiking neuromorphic processor. They...

Great start of the new year!
A new manuscript just published showing yet again how design principles and strategies from biological perceptive systems enable robust processing on analog #neuromorphic electronic systems, despite their variability!
rdcu.be/d5o0d

2024: A Review of the Year in Neuroscience Feeling a bit wired

Cutting it a bit fine, but here’s my review of the year in neuroscience for 2024

The eighth of these, would you believe? We’ve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much more…
Published on The Spike

Enjoy!

medium.com/the-spike/20...

GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments | PNAS The pathological deposition of proteins is a hallmark of several devastating neurodegenerative diseases. These pathological deposits comprise aggre...

GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments

www.pnas.org/doi/10.1073/...

Neuronal ‘Ensemble’ Recording and the Search for the Cell Assembly: A Personal History This contribution is part of the special issue on the Hippocampus focused on personal histories of advances in knowledge on the hippocampus and related structures. An account is offered of the author...

Fantastic journey through the history of hippocampal extra cellular recording techniques and the search for cell assemblies by Bruce McNaughton.

onlinelibrary.wiley.com/doi/10.1002/...

𝗧𝗵𝗲 𝗰𝗹𝗮𝘂𝘀𝘁𝗿𝘂𝗺 𝗮𝗻𝗱 𝘀𝘆𝗻𝗰𝗵𝗿𝗼𝗻𝗶𝘇𝗲𝗱 𝗯𝗿𝗮𝗶𝗻 𝘀𝘁𝗮𝘁𝗲𝘀
This is looking like a must read!
doi.org/10.1016/j.ti...
#neuroscience

Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵

Together with some friends we built an optical Brain Machine Interface to see if cortical activity (PPC) can control behaviour in real time, without animals having to learn to use it. Here's what happened:

www.biorxiv.org/content/10.1...

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...

🔵 blue spot alert: Anita Luethi's team reports a dual role of #locuscoeruleus in #sleep in Nature Neuroscience @natureportfolio.bsky.social

1) high LC activity facilitates cortical microarousals
2) low LC activity is required for NREMS-to-REMS transitions

doi.org/10.1038/s415...

A metabolic function of the hippocampal sharp wave-ripple - Nature Sharp wave-ripples from the hippocampus are shown to modulate peripheral glucose homeostasis in rats, offering insights into the mechanism that links sleep disruption and blood glucose regulation in t...

The main output of the hippocampus is subcortical.
Today, for the last class on the neurophys of navigation & mem, we will discuss this fantastic paper by @davidtingley.bsky.social (Buzsaki Lab) showing a link btw hippocampal sharp wave-ripples & glucose release.

www.nature.com/articles/s41...

1/n

Thrilled that our paper on the role of the rat prelimbic cortex (PLC) in decision making is finally out! Three main findings are described in this thread

Co-authors: Jensen Palmer, Samantha White, and Kevin Chavez Lopez

doi.org/10.1523/JNEU...

Heard this argument before and about so many brain regions. Agree with insula, but also claustrum, locus coeruleus, basal ganglia (direct/indirect pathways) and cortico-thalamic connectivity are amazing.