Yixuan He's Avatar

Yixuan He

@heyix.bsky.social

Assistant Professor @UTHealth, human genetics and clinical informatics🧬 previously @Harvard

24 Followers  |  25 Following  |  2 Posts  |  Joined: 26.05.2025  |  1.343

Latest posts by heyix.bsky.social on Bluesky


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Dissecting pleiotropy to gain mechanistic insights into human disease Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...

Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

28.11.2025 13:10 — 👍 41    🔁 15    💬 0    📌 0

Our work leverages large clinical biobank data (>35K patients across five cancers) from Dana Farber Cancer Institute (PI @sashagusevposts.bsky.social ) and MD Anderson (PI David Qian), very grateful for their help and support. There’s lots of interesting results, so come by to learn more! 🤩

14.10.2025 17:33 — 👍 1    🔁 0    💬 0    📌 0
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Very happy to be back in Boston for #ASHG25🧬 this time as a PI! Very proud of my stellar PhD student Jiawei who’s giving a platform talk on her work quantifying influences of genetic ancestry and the environment on tumor somatic alterations and survival.
🗓️ Wed Oct 15 11:15AM

14.10.2025 17:32 — 👍 5    🔁 1    💬 2    📌 0

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