Dave Shechner

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

A day late but STILL IMPORTANT

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

Woohoo! So psyched to see this awesome work from the Jovanovic lab out in the world! Congrats to all the authors on this tour-de-force!

www.cell.com/cell/fulltex...

Aw man, the pleasure was all mine!! 🙏🙏🙏

What is Phthalo Bluegrass?

Thanks, Dan!!

Thanks!! I hope you enjoy it!

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac

They will take over the middle parts of our feeds, surely.

when you love the em-dash #punctuation #grammar #writing #comedy TikTok video by Alexis Gay

www.tiktok.com/@yayalexisga...

Invariably there’s a moment in all of my trainees’ careers where I have to explain the difference between hyphens, en-dashes, and em-dashes, and they look at me like, “what happened to you?!” And I just kinda’ stare off to space and wonder the same thing…

Ridiculous. There’s no fourth month…

FUN FACT:
In Europe, they celebrate #PiDay on the 3rd day of the 14th month.

Who is the Grammar Hammer?

But that pentavalent carbon though…

TOP FIVE METABOLIC PATHWAYS
…Based on whether they sound like the name of an old-school anime:

5. The Pentose-Phosphate Shunt

4. Peptidoglycan Degradation

3. Fatty Acid Beta-Oxidation

2. The Dark Reactions of the Calvin Cycle

1. Gluconeogenesis

Such awesome work from @nandangokhale.bsky.social, @ramlabuw.bsky.social, and colleagues! Fantastic seeing this paradigm-changing study out in the wild. Congrats, everyone!

Good gravy, I have the keyboard shortcuts for all of these memorized, and I just don't know what to do with my life.

See also, 5' ≠ 5´

Indeed,

– ≠ —

(Welcome, welcome, @bartellab.bsky.social!)

Aw, yeah! It’s en-dash time, people!

No joke, I *have* been invited to present my work at a “conference” on food preservation and storage technologies… which I assume would include salted, canned ham.

Oh, they definitely will. I've also seen many protocols (including some commercial kits) that use amine-modified oligos, which are coupled by some sort of sequential coupling rxn. But they all require *gobs* of oligo to synthesize, which gets pricey when you're working with 90mers...

Ooh! This looks quite Interesting; thanks!!

Thanks! I’ll give this a read!

Oh man, Ribosome Display jumps to my mind reliably 2-3x per day. 🤣 But here I feel like it’s overkill.

Alas, it is Cys-free. So we could try to make a recombinant variant with an added Cys, but that becomes a whole project…