Thanks to everyone involved in this study, this would have not been possible without you!

27.11.2025 06:13 — 👍 0    🔁 0    💬 0    📌 0

Across multiple examples we find that inhibitors can tilt the balance towards less stable protein states. This triggers kinase destabilisation via native degradation routes. Spoiler: this also works for non-kinases (following soon)...

27.11.2025 06:13 — 👍 1    🔁 0    💬 1    📌 0

Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...

27.11.2025 06:13 — 👍 29    🔁 6    💬 1    📌 1

🧬 Kinase Inhibitors can do more than block their targets!
A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential.

Out in @nature.com
➡️ bit.ly/43SD9xj

26.11.2025 16:05 — 👍 15    🔁 7    💬 1    📌 1

🧬Kinase inhibitors that degrade?
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1

26.11.2025 16:08 — 👍 11    🔁 7    💬 0    📌 0

Georg Winter and first author Natalie Scholes (c) Barbara Bachmann/CeMM

New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD

26.11.2025 16:14 — 👍 17    🔁 6    💬 0    📌 0

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

02.09.2025 17:26 — 👍 58    🔁 24    💬 0    📌 0

Integration of diverse bioactivity data into the Chemical Checker compound universe - Nature Protocols The Chemical Checker is a collection of small-molecule bioactivity signatures organized in increasing levels of biological complexity. This protocol describes how to incorporate new data, create novel...

🔬A new computational protocol to explore bioactivity spaces and signatures, out now in @natprot.nature.com!

Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker

Article ➡️ www.nature.com/articles/s41...

29.05.2025 08:30 — 👍 10    🔁 6    💬 1    📌 2

Primed for degradation: How weak protein interactions enable molecular glue degraders Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…

📝 🚨 Review alert from the Thomä Lab

@alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action.
tinyurl.com/mpmbuuky

08.05.2025 09:08 — 👍 15    🔁 7    💬 0    📌 0

Hello, we are AITHYRA!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.

Check out the brand design video (sound on!) to learn more.

**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!

28.04.2025 08:38 — 👍 19    🔁 8    💬 0    📌 0

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

10.04.2025 01:22 — 👍 210    🔁 198    💬 6    📌 1

AITHYRA

🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds

Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz

07.04.2025 12:52 — 👍 14    🔁 9    💬 0    📌 0