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@sgrosche.bsky.social

17 Followers  |  67 Following  |  1 Posts  |  Joined: 18.11.2024  |  1.3231

Latest posts by sgrosche.bsky.social on Bluesky


DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.

Our new preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint: www.biorxiv.org/content/10.6...

16.01.2026 13:08 — 👍 1    🔁 2    💬 0    📌 0
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FDA grants accelerated approval to zongertinib for non-squamous NSCLC On August 8, 2025, the Food and Drug Administration granted accelerated approval to zongertinib (Hernexeos, Boehringer Ingelheim Pharmaceuticals, Inc.), a kinas

The @fda.gov granted accelerated approval to the HER2 inhibitor zongertinib for certain adults with unresectable or metastatic non-squamous non-small cell lung cancer whose tumors harbored mutations in the tyrosine kinase domain of HER2: buff.ly/Fq0u3yt

08.08.2025 18:50 — 👍 3    🔁 1    💬 0    📌 1
Celebrating our #WomenInSTEM: Ana Pombo
YouTube video by Max Delbrück Center Celebrating our #WomenInSTEM: Ana Pombo

"There’s really only one advice: work as hard as you can. [...] If more of us are trying, more of us are succeeding, and others are being carried through", says @apombo1.bsky.social Pombo, group leader at the #mdcBerlin | #mdcBIMSB.

👇 Watch the video and share to inspire others!

17.02.2025 08:31 — 👍 14    🔁 4    💬 0    📌 0
Introduction | EACR-Boehringer Ingelheim Conference: Drugging and Regulating the MAP Kinase Pathway | The European Association for Cancer Research

Starting soon @helloeacr.bsky.social

eacr.org/conference/b...

11.02.2025 11:54 — 👍 3    🔁 1    💬 0    📌 0
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Ref2501: Master thesis in Translational Cancer Research (Zuber lab) | Research Institute of Molecular Pathology

Are you a student with an interest in translational #cancer research? The lab of our Johannes Zuber (@johanneszuber.bsky.social) is recruiting a #masters student: www.imp.ac.at/career/open-...

#oncology, #cancerresearch, #masters

07.01.2025 16:28 — 👍 7    🔁 3    💬 0    📌 0

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