Raphaël Pantier

TriRhena Gene Regulation Club The TriRhena Gene Regulation Club is a one-day symposium that brings together researchers from France (IGBMC), Germany (MPI-IE) and Switzerland (FMI) who share a common interest in gene regulation.

👉 The next TriRhena Gene Regulation Club takes place at the Friedrich Miescher Institute @fmiscience.bsky.social in Basel.

📅 Nov. 5th, 2025 (14:00-20:00)
📌 FMI, Basel
✍️ Registration deadline: Oct. 20th, 2025

Attendance is free 💸 , but registration mandatory:
www.ie-freiburg.mpg.de/gene-regulat...

Could I be added to the list as well? Thanks Alexis :)

Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...

Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.

The human proteome with direct physical access to DNA Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-aci...

Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵

🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...

Low overlap of transcription factor DNA binding and regulatory targets - Nature A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.

Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets

https://go.nature.com/4jedGUz

Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602 The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

🚨3 weeks left to apply!🚨
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...

Hey! Check out our latest publication. A great collaboration with @longchrom.bsky.social and a nice example of how a negative result, the absence of a response to a transcriptional perturbation, can actually reveal an intriguing gene-specific buffering mechanism.
www.science.org/doi/10.1126/...

Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter LSI PHD studentship – start September 2025 or January 2026 Project 1: Title of Project: Control of chromatin remodeller activity...

Fully funded (at UK home rate) #PhD studentships to start 2025/2026 at University of Exeter, UK. #Chromatin #StemCells #Signalling #ProteinStructure #LineageCommitment #Transcription

Please spread the word, and anyone interested please contact me.

lsi.exeter.ac.uk/groups/hendr...

Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602 The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...

Hey! This was the result of a fantastic collaboration with the @longchrom.bsky.social lab, where we found evidence for a gene-specific buffering mechanism to compensate for transcriptional perturbations.

This schematic illustrates the interplay between transcription coactivator perturbations (e.g., TIP60 or ATAC complex depletion) and RNA homeostasis. Perturbations lead to alterations in mRNA synthesis, which are counterbalanced by changes in mRNA export and cytoplasmic decay of specific transcripts, thereby maintaining RNA homeostasis.

Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs

Cohesin as an essential disruptor of chromosome organization Chromosomes are long strings of DNA carrying multiple genes. A chromosomal factor called cohesin creates loops of DNA proposed to be functional units of the genome. By contrast, it is proposed here th...

This is not my normal field but it was written by my husband- he is meant to be promoting it but doesn't do social media so you have to make do with me instead 😄

Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...

The next TriRhena Gene Regulation Club takes place at
IGBMC #Strasbourg. Save your seat & submit a talk. Strengthen your local #epigenetics network & collaborate with peers.

📅 5 Feb. 2025 | 14:00
🎟️ Free entry, registration required
✍️ Register by: 24. Jan.

www.ie-freiburg.mpg.de/gene-regulat...

Edinburgh skyline with Calton Hill

Loved being back in Edinburgh. Such a beautiful city, such great science. Great to catch up with Adrian, @cathyabbott.bsky.social @cellysally.bsky.social @hannahlong.bsky.social @kashyapchhatbar.bsky.social @r-pantier.bsky.social et al. Thanks Cath+Adrian for the hospitality and Congrats Sara!