BiologyTechnion

CARMIL2 deficiency disrupts activation-induced metabolic reprogramming in T cells, and is partially rescued by glutamine supplementation T-cell activation requires signaling through the T-cell receptor and costimulatory molecules, including CD28, triggering metabolic reprogramming to su…

CARMIL2 deficiency disrupts activation-induced metabolic reprogramming in T cells, and is partially rescued by glutamine supplementation www.sciencedirect.com/science/arti...

Excited to share our new paper in Nature! 'Transcriptomic neuron types vary topographically in function and morphology' explores how neurons in the zebrafish optic tectum exhibit diverse functions and shapes despite similar transcriptional profiles.

🔗 rdcu.be/d9GVM

Meet Sheila and Alina, graduates of our faculty and EMBO postdoctoral fellows - פקולטה לביולוגיה Biology Faculty biology.technion.ac.il/en/meet-shei...

our new paper on pelagic #Asgard archaea that use #rhodopsins with carotenoid antennas to harvest light energy in the oceans.
Structural insights into light-harvesting by antenna-containing rhodopsins in marine Asgard archaea www.nature.com/articles/s41... @galitzlil.bsky.social

Scientific bedlam at the world’s weirdest and wildest research conference Woodstock Bio2 + Night Science aimed to encourage collaborations through creativity. The walk-on music for presentations was fun, too.

Scientific bedlam at the world’s weirdest and wildest research conference www.nature.com/articles/d41... @odedrechavi.bsky.social @sheilaroitman.bsky.social @alinapi.bsky.social @barakrotblat.bsky.social

Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others

Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests | Science | AAAS www.science.org/content/arti...

A Resilient Journey Through Science – People – EMBO Meet Sheila Roitman, EMBO Postdoctoral Fellow at Max Planck Institute for Biology

A Resilient Journey Through Science www.embo.org/people/a-res...

Frank Stahl, screen capture from: https://youtu.be/7-tnuAqEp9g

RIP Franklin W. Stahl (1929–2025)

here is Frank explaining semiconservative replication of DNA in the marvelous interview from 2020 together with Matt Meselson (youtu.be/7-tnuAqEp9g)

Thinking out of the box – People – EMBO Meet Alina Pushkarev, EMBO Postdoctoral Fellow, Humboldt University of Berlin

Thinking out of the box www.embo.org/people/think...

YouTube video by Science Communication Lab The Most Beautiful Experiment: Meselson and Stahl

Frank Stahl died today at 95. He and his colleague Matt Meselson found a way to demonstrate how DNA replicated. Their lab experiment has been called the "most beautiful experiment". Here's a video of them describing how they did it. Video h/t NYT. #science
www.youtube.com/watch?v=7-tn...

Harvey Prize Symposium on Cancer Epigenetics. Honoring the 2022–2023 Laureates

Intrinsically disordered regions facilitate Msn2 target search to drive promoter selectivity Transcription factors (TFs) regulate gene expression by binding specific DNA motifs, yet only a fraction of putative sites is occupied in vivo. Intrinsically disordered regions (IDRs) have emerged as ...

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New preprint!
How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites?

www.biorxiv.org/content/10.1...
#TranscriptionFactors #IDPs #SingleMolecule #Biophysics

Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics www.biorxiv.org/content/10.1...

Seasonal Enhancement of the Viral Shunt Catalyzes a Subsurface Oxygen Maximum in the Sargasso Sea www.biorxiv.org/content/10.1...

Design, synthesis, and screening of an RNA optimized fluorinated fragment library Fragment-based screening is an efficient method for early-stage drug discovery. In this study, we aimed to create a fragment library optimized for pro…

Design, synthesis, and screening of an RNA optimized fluorinated fragment library www.sciencedirect.com/science/arti...

Emerging implications for ribosomes in proximity to mitochondria Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are local…

Emerging implications for ribosomes in proximity to mitochondria www.sciencedirect.com/science/arti...

Resilience and charge-dependent fibrillation of functional amyloid: Interactions of Pseudomonas biofilm-associated FapB and FapC amyloids FapC and FapB are biofilm-associated amyloids involved in the virulence of Pseudomonas and other bacteria. We herein demonstrate their exceptional thermal and chemical resilience, suggesting that thei...

Resilience and charge-dependent fibrillation of functional amyloid: Interactions of Pseudomonas biofilm-associated FapB and FapC amyloids www.jbc.org/article/S002...

Consolidation of behavioral synchronization with the developmental clock is impaired by the degeneration of a mechanosensory circuit in C. elegans www.biorxiv.org/content/10.1...

Transcriptomic neuron types vary topographically in function and morphology - Nature Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...

Transcriptomic neuron types vary topographically in function and morphology www.nature.com/articles/s41...

Inferring single-cell and spatial microRNA activity from transcriptomics data - Communications Biology This study introduces miTEA-HiRes, a method designed to facilitate the evaluation of miRNA activity at high resolution. The method applies to single cell transcriptomics, type-specific single cell pop...

Inferring single-cell and spatial microRNA activity from transcriptomics data www.nature.com/articles/s42...

Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states www.sciencedirect.com/science/arti...

Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins elifesciences.org/articles/83973

The PVD neuron has male-specific structure and mating function in Caenorhabditis elegans www.pnas.org/doi/10.1073/...

outdoor lab cleaning. north shores of Lake Kinneret....

The PVD neuron has male-specific structure and mating function in Caenorhabditis elegans | PNAS Neurons display unique shapes and establish intricate networks, which may differ between sexes. In complex organisms, studying sex differences in s...

Paper of the month. The winner of February’s article is Yael Iosilevskii from Prof. Benjamin Podbilewicz Lab. CONGRATULATIONS!!
www.pnas.org/doi/10.1073/...

sampling some sinkholes near the Dead Sea.....

Huge congratulations to my first PhD student—and truly one-of-a-kind scientist and person—Einav Tayeb-Fligelman, on accepting a faculty position at the Hebrew University of Jerusalem! Reminiscent of the path - from Technion's synchrotron trips, to celebrating your new role in my CSSB/DESY lab💕

פיתוח בצפון הארץ: הדובדבן שמקדים את זמנו חוקרים ממו"פ צפון הצליחו להקדים בחודש את מועדי הפריחה וההבשלה של דובדבן מזן "רויאל דון" - ופתחו תחרות בין המגדלים: מי שיקדים לשווק את תוצרתו יקצור את הפירות הכלכליים

פיתוח בצפון הארץ: הדובדבן שמקדים את זמנו www.ynet.co.il/environment-...

Congratulations to Prof. Yoav Arava on receiving the FEBS Federation of European Biochemical Societies education award!

עוד מהסיור המקדים בים המלח ובבולענים. שרית אברני, אלינה פושקרב ושירלי לרום. פרוייקט ות״ת