Agostinis Lab

Thank you so much Geert!

BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states - Nature Metabolism Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately a...

Do melanoma cells rewire interorganelle iron flow? ⚡️We found that BDH2 controls lysosome-to-mitochondria Fe2+ transport, coupling lysosomal pH to ferroptosis vulnerability. Huge congrats to @francirizz.bsky.social, thanks to @juliebonnereau.bsky.social and collabs 🙏

www.nature.com/articles/s42...

Looking forward to giving a lecture at the 5th #Endoplasmic #Reticulum International Symposium of @inserm.fr in Paris!

📢 Only 2 Weeks Left for Early Registration!
The early registration deadline for ECDO-2025 @ecdoorg.bsky.social is fast approaching — July 7th is just around the corner! Fantastic program and speaker lineup, you cannot miss it! www.ecdo.eu/ecdo2025/ #ECDO #CellDeathResearch

Thank you so much Pedro and Ancely for highlighting our study 🙏

Organelle conversations drive ferroptosis - Nature Cell Biology Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain....

Organelle conversations drive ferroptosis -

news and views on a recent study by @mariamls.bsky.social and colleagues

www.nature.com/articles/s41...

Honored to have our image @mariamls.bsky.social featured on the June cover of NCB! It's a stunning depiction of #ER-mitochondria hotspots in #ferroptosis. Huge thanks to @natcellbio.nature.com team for this awesome recognition of our work. @viblifesciences.bsky.social
www.nature.com/ncb/volumes/...

Thank you so much Antonio!

Thank you Alex!

Thank you Geert!

Thank you so much Jessalyn!

* Modulation of EMCS’s integrity and function emerges as a therapeutic strategy to control ferroptosis susceptibility in ferroptosis-resistant cancer cells.

*The vulnerability of triple-negative breast cancer cell phenotypes to ferroptosis directly correlates with EMCS’s structural integrity and contact site density.

* Oxi-lipidomics analysis of EMCS fractions reveals that these membranes are enriched in ferroptosis-prone phospholipid species, making these sites hotspots for initial phospholipid peroxidation.

* Phospholipid peroxide accumulation triggers expansion of EMCSs, facilitating the spreading of lipid-ROS to the mitochondria and inducing their fragmentation.

Highlights of the study
* Phospholipid peroxidation initiates within 5 minutes of ferroptosis induction, specifically at subdomains of the ER membrane in close contact with the mitochondria, called ER-mitochondria contact sites or EMCSs.

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...

Congratulations on your publication @francirizz.bsky.social! You revealed the secrets of mitochondria-lysosome contacts 👏👏👏 Another achievement .. soon the new one!

journals.sagepub.com/doi/10.1177/...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."

how it controls the melanoma drug tolerant persister state and the consequences of its perturbation on ferroptosis 2/2

Hi Bluesky crew! New here and excited to connect 😀 This is our most recent preprint where we describe the molecular machinery regulating iron transport between lysosomes and mitochondria.. 1/2
www.researchsquare.com/article/rs-5...