Roger Castells

Bugs on Flowers

Verano de bachillerato en el laboratorio: Aitana Soler y Jan Magem viven la realidad de la investigación científica en #CNIOStopCancer con el programa ‘Jóvenes y ciencia’ de la Fundació Catalunya La Pedrera. Han trabajado un mes junto a @rcastellsg.bsky.social, que también participó en el programa

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

Why I’m skipping the Congress this year (And why you should still publish your posters) Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…

I just published: Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a citable record and protects you from bad actors.

#ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat

medium.com/p/why-im-ski...

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

There is no better feeling than to see people in your lab succeed!

In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex @cp-cellreports.bsky.social @rcastellsg.bsky.social
www.cell.com/cell-reports...

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

My last day at the @gmivienna.bsky.social & @viennabiocenter.bsky.social. Here’s what I accumulated at my (office) 🚪 🧵 1/advice from my daughters

Thanks a lot Mart! :)

Muchas gracias JC! :)

Thanks a lot Charles! :)

Honored and grateful to receive the Hawk Biosystems Award from the Spanish Biophysical Society 🙏 Thank you very much for this recognition! :)

Roger Castells-Graells recibe el premio Hawk Biosystems de la Sociedad de Biofísica de España El investigador Roger Castells-Graells, del Centro Nacional de Investigaciones Oncológicas (CNIO), ha recibido el premio “Hawk Biosystems”, que otorga la Sociedad de Biofísica de España (SBE) en el marco de su XVIII Congreso Internacional. Castells-Graells se incorporó recientemente al CNIO para dirigir el nuevo Grupo de Diseño Biomolecular y Nanomedicina Estructural, dedicado a crear nanopartículas […]

Roger Castells-Graells, Premio Hawk Biosystems de la Sociedad de Biofísica de España a la trayectoria de investigadores de menos de 33 años.

@rcastellsg.bsky.social dirige el Grupo de Diseño Biomolecular y Nanomedicina Estructural de #CNIOstopcancer.

El CNIO crea 'nanopartículas de proteínas' para acelerar el desarrollo de fármacos contra el cáncer Las proteínas son moléculas complejas que realizan funciones cruciales en el organismo. Conocerlas es esencial para comprender e intentar curar enfermedades: si se conoce la estructura tridimensional de una proteína implicada en cáncer, por ejemplo, se puede intentar diseñar una molécula capaz de modificar esa proteína para tratarlo.     El Grupo de Diseño Biomolecular y […]

El #CNIOStopCancer crea ‘nanopartículas de proteínas’ para acelerar el desarrollo de fármacos contra el cáncer y detectar antes la enfermedad. Es el objetivo del nuevo Grupo de Diseño Biomolecular y Nanomedicina Estructural, dirigido por @rcastellsg.bsky.social  

Our lab at CNIO is featured in its first press release! So proud of the team! 😊

#CancerResearch #Nanomedicine #RCGLab #CNIO

@cniostopcancer.bsky.social

The surprising power of your nature photos Scott Loarie has a challenge for you: go outside and take a picture of a living thing. He introduces the global community of people building a living atlas of the natural world by sharing their nature...

Super cool: “The surprising power of your nature photos” 🌱🍀🌷🦋
@inaturalist.bsky.social

www.ted.com/talks/scott_...

Drowning Doesn’t Look Like Drowning Drowning is not the violent, splashing call for help that most people expect.

Thanks for the reminder @janemunday.bsky.social. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on.

slate.com/technology/2...

Super cool! 🤩

The diatom tree of life.

Diatoms are tiny but ecologically important eukaryotes. After over a million years of relative stasis, the lineage of diatoms exploded into diversity, with innovations in ecology, morphology, and life history still seen today. In PNAS: www.pnas.org/doi/10.1073/...

We added Boltz-2 to our protein design package! Under the hood this relies on a JAX translation, which, thanks to @jeremywohlwend.bsky.social and @gcorso.bsky.social ’s clean code, was fairly easy to write. We’ve been getting great results -- and we have yet to explore the most exciting new features

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

🤩🤩🤩 Boltz-2!!

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n
📄 www.biorxiv.org/content/10.1...
💾 github.com/steineggerla...

Hi everyone! I’m new to Bluesky. At the beginning of the year, I moved to Zurich @UZH_en to start a postdoc with #CyrilZipfel and @pedrobeltrao.bsky.social, investigating protein phosphorylation in plants 🌱

If you’re nearby or working on something similar, let’s connect 😀

We’re now working on a database. It’s the first time we do it, so still learning. :)

The easiest way for us to know if we have a model for that specific protein is to search by the sequence. In an excel file, we would include the sequence in one of the columns. Or it is also possible to use tools like the “grep” command in Linux to search for specific text.

The selected designs we list them on an excel file. Each project has its directory structure.

In our case, for the designs we generate thousands of sequences, run predictions and use multiple filters, using a pipeline similar to the one described in the Bindcraft manuscript. For each sequence we generate we make a prediction.