Roger Castells

Check out our latest work on the discovery and engineering of PiggyBac transposases! 🧵

Postdoctoral Research Assistant for the Biomolecular Design and Structural Nanomedicine Group DescriptionWe are looking for a Postdoctoral Researcher to join Roger Castells-Graells’ lab at the Spanish National Cancer Research Centre (CNIO). The successful candidate will work on innovative biom...

We’re looking for an enthusiastic postdoc to join our team. 😊

The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪

The position is fully funded for 3 years.

Please share 🙏

Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.

I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions.

@aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social

www.nature.com/articles/s41...

🤩🤩

Happy anniversary!! :)

Wow! So cool to see new mysterious protein complexes 🤩 so much to discover 🔬

🥳Congrats to Prof. David Eisenberg, who has been awarded the 2026 Gregori Aminoff Prize in Crystallography by the Royal Swedish Academy of Sciences! www.chemistry.ucla.edu/news/david-e...

This is super cool and great investigative work! Thanks Oli and co! #smallparticles #cryoEM

One mother for two species via obligate cross-species cloning in ants - Nature In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

Look at this crazy thing!
www.nature.com/articles/s41...

I love the symmetry of the library! 🤩

Bugs on Flowers

Verano de bachillerato en el laboratorio: Aitana Soler y Jan Magem viven la realidad de la investigación científica en #CNIOStopCancer con el programa ‘Jóvenes y ciencia’ de la Fundació Catalunya La Pedrera. Han trabajado un mes junto a @rcastellsg.bsky.social, que también participó en el programa

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

Why I’m skipping the Congress this year (And why you should still publish your posters) Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…

I just published: Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a citable record and protects you from bad actors.

#ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat

medium.com/p/why-im-ski...

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

There is no better feeling than to see people in your lab succeed!

In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex @cp-cellreports.bsky.social @rcastellsg.bsky.social
www.cell.com/cell-reports...

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

My last day at the @gmivienna.bsky.social & @viennabiocenter.bsky.social. Here’s what I accumulated at my (office) 🚪 🧵 1/advice from my daughters

Thanks a lot Mart! :)

Muchas gracias JC! :)

Thanks a lot Charles! :)

Honored and grateful to receive the Hawk Biosystems Award from the Spanish Biophysical Society 🙏 Thank you very much for this recognition! :)

Roger Castells-Graells recibe el premio Hawk Biosystems de la Sociedad de Biofísica de España El investigador Roger Castells-Graells, del Centro Nacional de Investigaciones Oncológicas (CNIO), ha recibido el premio “Hawk Biosystems”, que otorga la Sociedad de Biofísica de España (SBE) en el marco de su XVIII Congreso Internacional. Castells-Graells se incorporó recientemente al CNIO para dirigir el nuevo Grupo de Diseño Biomolecular y Nanomedicina Estructural, dedicado a crear nanopartículas […]

Roger Castells-Graells, Premio Hawk Biosystems de la Sociedad de Biofísica de España a la trayectoria de investigadores de menos de 33 años.

@rcastellsg.bsky.social dirige el Grupo de Diseño Biomolecular y Nanomedicina Estructural de #CNIOstopcancer.

El CNIO crea 'nanopartículas de proteínas' para acelerar el desarrollo de fármacos contra el cáncer Las proteínas son moléculas complejas que realizan funciones cruciales en el organismo. Conocerlas es esencial para comprender e intentar curar enfermedades: si se conoce la estructura tridimensional de una proteína implicada en cáncer, por ejemplo, se puede intentar diseñar una molécula capaz de modificar esa proteína para tratarlo.     El Grupo de Diseño Biomolecular y […]

El #CNIOStopCancer crea ‘nanopartículas de proteínas’ para acelerar el desarrollo de fármacos contra el cáncer y detectar antes la enfermedad. Es el objetivo del nuevo Grupo de Diseño Biomolecular y Nanomedicina Estructural, dirigido por @rcastellsg.bsky.social  

Our lab at CNIO is featured in its first press release! So proud of the team! 😊

#CancerResearch #Nanomedicine #RCGLab #CNIO

@cniostopcancer.bsky.social

The surprising power of your nature photos Scott Loarie has a challenge for you: go outside and take a picture of a living thing. He introduces the global community of people building a living atlas of the natural world by sharing their nature...

Super cool: “The surprising power of your nature photos” 🌱🍀🌷🦋
@inaturalist.bsky.social

www.ted.com/talks/scott_...

Drowning Doesn’t Look Like Drowning Drowning is not the violent, splashing call for help that most people expect.

Thanks for the reminder @janemunday.bsky.social. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on.

slate.com/technology/2...