Sten Linnarsson

If you were alive in the 1980s, this is among the most wonderful & truly incredible things you have ever witnessed in your lifetime.

Trump team axes contracts with publishing giant Springer Nature The action comes as high-ranking US officials criticize top journals as ‘woke’ and ‘corrupt’.

”All contracts with Springer Nature are terminated or no longer active. Precious taxpayer dollars should be [sic] not be used on unused subscriptions to junk science.” the NIH spokesperson said. www.nature.com/articles/d41...

Assistant Professor in Experimental Tumor Biology Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universitie

We're looking for a new Assistant Professor in Experimental Tumor Biology to join us at Karolinska Institutet (MTC) @ki.se .
Generous funding package and part of a 20 Assistant Prof recruitment in a wide range of subject areas.
📅 Deadline: Sep 2nd, 2025
ki.varbi.com/en/what:job/...

1/3 I spent 10 years running a lab in Philadelphia and then decided to return to Europe and continue in a more family friendly environment. Best decision of my life! You can now do the same by applying to one of these 20 assistant professor positions at Karolinska Institutet ki.se/en/about-ki/...

Assistant Professor in Biomedical Science Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,

Come join our department at the Karolinska Institute! ki.varbi.com/what:job/job...

There are no h-index requirements. We will assess your proposal, CV, and the eligibility requirements (e.g. max 7 years after PhD with time allowed for certain activities). The key is to adress an important challenge, with a novel approach, reasonably feasible. But each position has its own profile!

The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...

These are the ads from my departments (as dean) but there are many more across the institute: ki.se/en/about-ki/...

Assistant Professor in epidemiology or biostatistics at MEB Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,

The Department of Medical Epidemiology will recruit in epidemiology and biostatistics. Six years, 9 MSEK startup package.

ki.varbi.com/what:job/job...

Assistant Professor in Environmental Medicine Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,

The Institute of Environmental Medicine will recruit in, yes, environmental medicine. Six years, 12 MSEK startup package.

ki.varbi.com/se/what:job/...

Assistant Professor in Experimental Tumor Biology Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universitie

The Department of Department of Microbiology, Tumor and Cell Biology will recruit in Experimental Tumor Biology. Six years, 12 MSEK startup package.

ki.varbi.com/en/what:job/...

Assistant Professor in Human physiology or medicine of extreme environments Assistant Professor in Human physiology or medicine of extreme environments Karolinska Institutet, Department of Physiology and Pharmacology Join a global community of excellence Are you a bold, creat

The Department of Physiology and Pharmacology will recruit in ”physiology or medicine of extreme environments”. Six years, 12 MSEK startup package.

ki.varbi.com/se/what:job/...

Assistant Professor in Cell and Molecular Biology Join a global community of excellence Karolinska Institutet, Department of Cell and Molecular Biology Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Insti

The Department of Cell and Molecular Biology will recruit broadly in… cell and molecular biology: ”long-term projects with the prospect of leading to groundbreaking discoveries” Six years, 12 MSEK startup package.

ki.varbi.com/what:job/job...

Assistant Professor in Biomedical Science Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,

The Department of Medical Biochemistry and Biophysics (my dept) will recruit broadly in molecular experimental biomedicine: Fundamental human biology, disease and technology development. Six years, 12 MSEK startup package

ki.varbi.com/what:job/job...

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

In these turbulent times, beautiful microscopy always cheers me up 😍. Here's a quail neural tube just doing its thing for #FluorescenceFriday. Imaged by the very talented
@vanderspuy.bsky.social
#devbio 🧪🔬👩‍🔬

In vivo CAR T cell generation to treat cancer and autoimmune disease Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...

🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease @capstantx.bsky.social direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery www.science.org/doi/10.1126/...

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

Very cool work from James Zou. Link to paper: www.nature.com/articles/s41...

⚡️Really thrilled that #textgrad is published in @nature.com today!⚡️

We present a general method for genAI to self-improve via our new *calculus of text*.

We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

Single-step discovery of high-affinity RNA ligands by UltraSelex | Nature Chemical Biology Aptamers, nucleic acid ligands targeting specific molecules, have emerged as drug candidates, sensors, imaging tools and nanotechnology building blocks. The predominant method for their discovery, systematic evolution of ligands by exponential enrichment, while successful, is laborious, time-consuming and often results in candidates enriched for unintended criteria. Here we present UltraSelex, a noniterative method that combines biochemical partitioning, high-throughput sequencing and computational signal-to-background rank modeling for discovering RNA aptamers in about 1 day. UltraSelex identified high-affinity RNA aptamers capable of binding a fluorogenic silicon rhodamine dye and two protein targets, the SARS-CoV-2 RNA-dependent RNA polymerase and HIV reverse transcriptase, enabling live-cell RNA imaging and efficient enzyme inhibition, respectively. From the ranked sequences, minimal aptamer motifs could be easily inferred. UltraSelex provides a rapid route to reveal new drug candi

Discover aptamers faster! UltraSelex combines partitioning, high-throughput sequencing & computation in 1 step. Revolutionize drug discovery! PMID:40164941, Nat Chem Biol 2025, @nchembio https://doi.org/10.1038/s41589-025-01868-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

So we’ll be vibecoding science soon enough, and not just for DNA! The AI models need access to all of the literature, code and data of course. We’ll have to build fully autonomous labs for all common types of experiments. And then we hook it all up in a loop. Exciting times!

In all seriousness though, the tools already know enough of the literature to develop novel ideas, and can definitely reason about how to design DNA vectors and perform experiments. They just fall apart when actually writing DNA or protein sequences. That’s fixable.

Translated to DNA by ChatGPT:

en.m.wikipedia.org/wiki/Vibe_co...

New paper out in @pnas.org

We followed cells migrating along signalling gradients in 3D, and found they collectively behave as a living droplet - a self-propelling fluid that grows.

www.pnas.org/doi/10.1073/...

In my attempts to vibecode DNA, ChatGPT tends to just make up plausible-looking but random sequences, whereas Gemini sometimes just gets stuck in a nonstop flood of ”GCGCGCGCGC…”. Related, when Claude talks to itself it tends to ”spiral into poetic bliss” 😀 simonwillison.net/2025/May/25/...

Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection https://www.biorxiv.org/content/10.1101/2025.05.19.654765v1