@danmaclean.bsky.social
Head of Bioinformatics at The Sainsbury Laboratory, Hon Professor UEA Computer Science. Likes genomics, stats, proteomics, bioinformatics, R user, Python wrangler. Wiganer.
Penguin Classics cover of John Marr and other Sailors by Herman Melville. Cover image is a b/w promo photo of The Smiths
18.10.2024 20:45 β π 80 π 10 π¬ 2 π 1Have we not eaten while another starved? Will you punish us for that? Will you reward us for the virtue of starving while others ate? No man earns punishment, no man earns reward. Free your mind of the idea of deserving, the idea of earning, and you will begin to be able to think
29.11.2025 18:40 β π 50 π 17 π¬ 0 π 1LLMs are now widely used in social science as stand-ins for humansβassuming they can produce realistic, human-like text
But... can they? We donβt actually know.
In our new study, we develop a Computational Turing Test.
And our findings are striking:
LLMs may be far less human-like than we think.π§΅
Thank you very much, Gaurav, I appreciate you taking the time to say so.
27.10.2025 09:54 β π 0 π 0 π¬ 1 π 0(With apologies to Randall Munroe)
15.10.2025 07:36 β π 84 π 18 π¬ 1 π 0I really really really liked The Oatmealβs take on AI here theoatmeal.com/comics/ai_art
08.10.2025 13:57 β π 71 π 23 π¬ 3 π 2New pre-print from our group showing remarkable synchrony of proliferative growth and regulated cell death during plant infection- each conidial cell has a different fate - by the rice blast fungus. Led by Alice Eseola with @osesmir.bsky.social Lauren Ryder @danmaclean.bsky.social and Martin Egan
07.10.2025 15:29 β π 20 π 10 π¬ 1 π 02οΈβ£ For the love of all that remains sane in the world.
02.10.2025 16:49 β π 1 π 0 π¬ 0 π 0Great to hear Burnham's been to Mancwalk 2000.
25.09.2025 09:41 β π 22 π 8 π¬ 0 π 0Normalize never saying "leverage" or "utilize" as a verb. Tempted? "Use" is right there!
Simple words are better words
"It has never been clearer: this is a class war, mediated through one person."
Love this article from @zoesqwilliams.bsky.social. I snorted several times, but she makes some serious points: in the eyes of the tabloids, the working class Rayner can't win, whatever she does.
$ ls -laht
drwxrwsr-x 3 uname grp 27 Nov 16 2006 .nautilus
drwxrws--- 3 uname grp 26 Nov 16 2006 .metacity
-rwxrwx--- 1 uname grp 26 Nov 16 2006 .dmrc
π
Chris outlining the different AI coding agents that can be used for ontology development. Working on documenting best practices for this ai4curation.GitHub.io/aidocs #BOSC2025 #ISMBECCB2025
22.07.2025 10:59 β π 5 π 3 π¬ 0 π 0Today #BOSC2025 and #BOKR (formerly Bioontologies) COSIβs, Chris Mungall is doing the keynote on Open KBs in the age of generative AI #ISMBECCB2025
22.07.2025 10:32 β π 2 π 3 π¬ 1 π 0*Learning visualization in Python as an R user*
#ggplot
I work with a lot of very intelligent people - the experts in a very select field - yet every morning they fight over the parking spots in the shade. By lunchtime they're all in full sun and my unwanted "sunny" spot keeps my car nice and cool. They never learn.
21.07.2025 07:20 β π 420 π 12 π¬ 13 π 1AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...
I recently ran a session at CSAMA with Laurent Gatto and this is the way. "Good enough" with knowledge of the tools that can help you get there. Here's some of the recs from the paper.
13.07.2025 05:13 β π 37 π 8 π¬ 1 π 0π This is good to hear. My kid is past kpop phase so won't choose it, but I put it on my mental watchlist as a candidate for one of those nothing else on, dad can still choose some good things, type evenings.
10.07.2025 13:13 β π 1 π 0 π¬ 0 π 0Nice. An API is like a structured set of URLs for querying data that you can send to someone's computer and they'll send you an appropriate response. Eg api.mcdonalds.com/menu/sold/cheeseburger might return 31234543219494938263628 (some big number, anyway)
19.06.2025 16:59 β π 1 π 0 π¬ 1 π 0I told you weβd be back
12.06.2025 16:15 β π 42833 π 12652 π¬ 1564 π 5140If it was a small sample I might try Internet archives set of scanned magazines, iirc they have ads scanned or you might find it in reviews archive.org/details/comp...
23.05.2025 07:33 β π 2 π 0 π¬ 0 π 0I use this yihui.org/tinytex/ (mostly through quarto so ymmv) but it's ok for that.
22.05.2025 16:56 β π 0 π 0 π¬ 0 π 0A SKLEATON RISIN UP OUT OF DA GRAVE 2 REMIND YOU THAT DA A.I SHIT THATS GOING AROUND NOW IS DA SAME AS EVERY OTHER COMPUTER SCAM , AND THE BEST ITS GOT AFTER TRILLION'S OF DOLLARS OF MONEY AND SO MANY COMPUTERS THAT WE HAD TO OPEN NEW POWER PLANTS TO RUN THEM , IS : 1. VIDEO'S OF PEOPLE WHO ARE MOVING AROUND SLOWLY IN A WEIRD WAY, 2. PHOTO'S OF JESUS WHERE HES IN A SHOPPING MALL WITH THE PRESEDENT, 3. CODE THAT DOSENT WORK, 4. INCORRECT SUMMARY OF INFOMATION THAT YOU PASTE INTO IT, 5. NOW DUMB GUYS THINK THAT THE COMPUTER IS SAD OR SMART!!! THERE ALL BAD BUT THE WORST PART IS THAT THE WORST GUYS IN THE WORLD ARE MAKEN A SHIT LOAD OF MONEY OFF OFF IT AND IT DOESNT EVEN WORK, ANYWAY THE TEXT SAYS " REMEMEBER NFT'S? SORT OF? NOT REALLY? THE SAME GUYS WHO MADE THAT BULLSHIT ARE NOW TELLIN US AUTO COMPLETE IS INTELEGENT AND IT HAS FEELINGS" - DASHARE.ZONE ADMIN
"AI" - dashare.zone ADMIN
14.05.2025 21:18 β π 4614 π 1820 π¬ 0 π 28Afternoon stroll
04.05.2025 20:42 β π 2 π 0 π¬ 1 π 0I would say don't. Take the opportunity to start per project libraries with renv.
24.04.2025 20:18 β π 0 π 0 π¬ 0 π 0