Michal Minczuk

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

Mechanisms of Mitochondrial DNA Mutation and Repair - MitoWorld If our website is MitoWorld, the Mechanisms of Mitochondrial DNA Mutation and Repair conference was the introductory gathering of what could be called “mtDNA World.” The organizers, Patrick Chinnery (...

The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville!

From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event.

See the full recap 👇

mitoworld.org/mechanisms-o...

Image of Professor Michal Minczuk and his biography. Michal Minczuk will be speaking at Euromit on Wednesday 3 of June 2026 during the Session 5 entiteld "Innovative technologies". Michal Minczuk is a professor of Mitochondrial Genetics in the Department of Clinical Neurosciences at the University of Cambridge, UK. His research is focused on mitochondrial genetics, as well as on the development of innovative genome engineering technologies, to bring future therapies for diseases caused by mitochondrial dysfunction.

🎙️ Focus Speakers – Michal Minczuk
@mitogene.bsky.social

👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing Michal Minczuk who will be taking the stage at the congress.
#euromit2026 #mitochondria #angers @univangers.bsky.social @ua-recherche.bsky.social

Coverage of this important work led by @daniellahock.bsky.social and @dstroudlab.bsky.social who support our @lifearc.bsky.social research to replicate this

@medicalsciencesncl.bsky.social
@neygenomics.bsky.social
@mitocamb.bsky.social
@londonmito.bsky.social
@lilyfoundation.bsky.social

Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Postdoctoral fellowship (2 years) to study mitochondrial DNA stability

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research

We led a workshop on making complex science clear – because involving patients is key to success

#mitochondrialdisease #mitoresearch #patientvoice #raredisease

Thanks for organising @mrcmitocluster.bsky.social and @robpitceathly.bsky.social

Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬

#mitochondria #MouseModels #ECR

🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social

🗞️ doi.org/10.1038/s443...

Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...

Great opportunity!

Thanks Ramon!

It would not be possible without: Keira Turner, Chris Powell, @lindseyvanhaute.bsky.social Pedro Pinheiro, Felix Bubeck, Ellen Wiedtke, @ryanlab.bsky.social Dirk Grimm @mito-oncogene.bsky.social - Thank you!!

A decisive technical leap forward for personalized medicine to treat mitochondrial diseases | EMBO Molecular Medicine EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Many thanks to Abi Ghifari and Martin Ott @mitolab.bsky.social for featuring our paper in News & Views (and calling it a "decisive technical leap forward" in #MitochondrialDisease treatment development!) 🙌
www.embopress.org/doi/full/10....

Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...

Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....

Thanks Mike!

Thanks Lawrence

Pretzel Therapeutics Initiates Phase 1 Clinical Study Evaluating PX578, Lead Therapeutic in its Bioenergetics Restoration Franchise » Pretzel Therapeutics First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes

Exciting news from Pretzel Therapeutics! We’ve launched a Phase 1 trial for our POLG activator—PX578—targeting rare mitochondrial syndromes with potential for Parkinson’s & Alzheimer’s diseases.
Congratulations to the entire team—proud to be part of this journey!
www.pretzeltx.com/pretzel-ther...

We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/

Beacon's role in the LifeArc Translational Centres for Rare Disease - Beacon for rare diseases This week's blog is written by our CEO, Rick Thompson. He discusses our role in the new LifeArc Translational Centres for Rare Disease.

Really interesting read from #Beacon for RD about their involvement in the @lifearc.bsky.social centres for #raredisease Read it here:

www.rarebeacon.org/blog/beacons...

@lilyfoundation.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @mrc-mbu.bsky.social

Exciting News: Learn about the Speakers of Euromit 2026!
We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨
📢 See the full list ! 👇
#euromit2026 #mitochondria #science #innovation #angers

Looking forward to #IMGC2025 Glasgow next month!

MitoCluster will be delivering an #ECR Workshop on Mouse Models of #Mitochondrial DNA Disease, featuring cluster lead @robpitceathly.bsky.social and investigators Carlo Viscomi, @jim-ca.bsky.social, and @mitogene.bsky.social🐁

🌍Euromit 2026 is coming to Angers!🌍

✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨

📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch...
Please re-post!

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...