Pluchino lab - Regenerative Neuroimmunology

Dual lineage origins contribute to neocortical astrocyte diversity - Nature Communications Astrocytes display diverse molecular and functional features in the brain, but the developmental origins of this heterogeneity are not well understood. Here, the authors show that two separate progeni...

Dual lineage origins contribute to neocortical astrocyte diversity

www.nature.com/articles/s41...

Hot off the press! 🔥 Review in the Journal of Neurochemistry exploring neural stem cell-derived extracellular vesicles (NSC-EVs) as a promising therapy for neurodegenerative diseases!
We discuss how they fight inflammation & boost repair in the brain.

onlinelibrary.wiley.com/doi/10.1111/...

📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉  rupress.org/jem/pages/ea...

Dietary patterns and accelerated multimorbidity in older adults - Nature Aging In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...

Dietary patterns and accelerated multimorbidity in older adults | Nature Aging

www.nature.com/articles/s43...

Senolytics under scrutiny in the quest to slow aging | Nature Biotechnology

www.nature.com/articles/s41...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures: Cell

www.cell.com/cell/abstrac...

Methods and applications of in vivo CRISPR screening - Nature Reviews Genetics In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review outlines key criteria for understanding...

Methods and applications of in vivo CRISPR screening | Nature Reviews Genetics

www.nature.com/articles/s41...

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity - Nature Communications Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA repair pathways, overcoming drug...

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity | Nature Communications

www.nature.com/articles/s41...

The brain fires up immune cells when sick people are nearby When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.

The brain fires up immune cells when sick people are nearby

www.nature.com/articles/d41...

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an Al...

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4: Cell Reports

www.cell.com/cell-reports...

Lost in translation: rethinking animal models of progressive MS (an industry perspective) While multiple sclerosis (MS) therapies have successfully reduced relapse rates and new lesion development in the brain, people with MS continue to ex…

Lost in translation: rethinking animal models of progressive MS (an industry perspective) - ScienceDirect

www.sciencedirect.com/science/arti...

Resilience and brain health in global populations - Nature Medicine Unique biological, exposomal, economic and sociocultural factors shape resilience and brain health across the globe; this Review discusses underlying mechanisms of resilience, measurement approaches, ...

Resilience and brain health in global populations | Nature Medicine

www.nature.com/articles/s41...

Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Neural anticipation of virtual infection triggers an immune response | Nature Neuroscience

www.nature.com/articles/s41...

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Oxidative Phosphorylation in Uncoupled Mitochondria

onlinelibrary.wiley.com/doi/10.1002/...

Profiling Epigenetic Aging at Cell‐Type Resolution Through Long‐Read Sequencing Here we introduce LongReadAge, a probabilistic method leveraging long-read sequencing to profile epigenetic aging at cell-type resolution from a bulk sample, without cell sorting. Applied to bulk whi...

Profiling Epigenetic Aging at Cell‐Type Resolution Through Long‐Read Sequencing - Eames - Aging Cell - Wiley Online Library

onlinelibrary.wiley.com/doi/full/10....

Repair, Reset, Reimagine: Stem Cell Therapies for Multiple Sclerosis Podcast Episode · MS Living Well: Key Info from Multiple Sclerosis Experts · 07/22/2025 · 46m

📢 🎧New podcast alert: Stefano Pluchino features in Repair, Reset, Reimagine: Stem Cell Therapies for Multiple Sclerosis. Listen now ⬇️

Apple podcast: podcasts.apple.com/us/podcast/r...

MS Living Well: www.mslivingwell.org/2025/07/22/s...

How stem cells respond to infection, inflammation and ageing - Nature Reviews Immunology This Review by Poirier highlights the intrinsic mechanisms that protect stem cells from infection. The author also explains how stem cell populations in different tissue sites respond to infection or ...

How stem cells respond to infection, inflammation and ageing

www.nature.com/articles/s41...

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Mast cells regulate the brain-dura interface and CSF dynamics

www.cell.com/cell/fulltex...

Great seminar by @kajastelab.bsky.social on innate anti-viral immunity, inflammation & next-gen gene therapies! Implications for understanding cell function in new treatments for degenerative conditions like #progressiveMS

#multiplesclerosis #geneTherapy #immunology @camneurodept.bsky.social

A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors - Nature Aging Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting s...

A blood-based epigenetic clock for intrinsic capacity (IC) predicts mortality and is associated with clinical, immunological and lifestyle factors | ... and declines with age

www.nature.com/articles/s43...

Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...

Top-down and bottom-up neuroscience: overcoming the clash of research cultures

www.nature.com/articles/s41...

Loving the visit so far @cam.ac.uk Always nice to catch up with friends @guipap.bsky.social & meet new ones @prudentlab.bsky.social The #PhD VIVA went well, looking forward to my seminar and more interactions @camneurodept.bsky.social tomorrow. Thank you @pluchinolab.bsky.social for the invitation!

Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis Ditzer, Senoglu, et al. report that epigenetic factors of the Polycomb group regulate not only neurogenic gene expression programs but also the composition of the extracellular matrix in the human dev...

Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis

www.cell.com/neuron/fullt...

Advancing multiple sclerosis management in older adults - Nature Reviews Neurology Approximately half of the people currently with multiple sclerosis (MS) are ≥50 years of age, yet guidelines for management of MS in older age are lacking. This Consensus statement presents the outcom...

Advancing multiple sclerosis management in older adults

www.nature.com/articles/s41...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

www.cell.com/cell/fulltex...

What a night!
Our lab traded pipettes for axes, and let's just say we honed our missing skills with expert precision! 😉
It was an absolute blast seeing everyone de-stress and have a laugh, no matter where the axes landed 🪓🎯
Huge thanks to everyone! 👏
#Neuroscience #AxeThrowing #TeamBuilding

Spatial proteomics of Alzheimer’s disease-specific human microglial states - Nature Immunology In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.

Spatial proteomics of Alzheimer’s disease-specific human microglial states

www.nature.com/articles/s41...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

I think I have shared this already but this is indeed a fantastic piece of extremely elegant cell biology with profound potential implications in development, physiology and disease

www.science.org/doi/10.1126/...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects Walsh et al. establish a human forebrain assembloid protocol that supports the derivation of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in disease-associated structura...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects

www.cell.com/neuron/fullt...