Pluchino lab - Regenerative Neuroimmunology

Great fun working on this with the wonderful Evridiki Asimakidou, @pluchinolab.bsky.social and @lpjlab.org‬. l learned so much!🧠

🚨 Last CAJAL course of 2025 in Bordeaux!

Full list of speakers and their talks for “Neuroimmunology in Physiology and Disease” is now available.

@paolicellilab.bsky.social @agnesnadjar.bsky.social @pluchinolab.bsky.social

#Neuroimmunology #Neuroscience

Lymphoid gene expression supports neuroprotective microglia function - Nature PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...

Lymphoid gene expression supports neuroprotective microglia function

www.nature.com/articles/s41...

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

www.nature.com/articles/s42...

Evidence for improved DNA repair in long-lived bowhead whale - Nature Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

Evidence for improved DNA repair in long-lived bowhead whale

www.nature.com/articles/s41...

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

www.sciencedirect.com/science/arti...

Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders Liu et al. reveal that neutrophil extracellular traps (NETs) serve as markers of post-stroke emotional disorders. The infiltration of NETs into the brain parenchyma leads to the morphological and func...

Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders

www.cell.com/neuron/fullt...

Thrilled to welcome Chiara Garsia to the lab as a visiting PhD student.
With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells.
Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch

Artificial intelligence in metabolic research

www.nature.com/articles/s42...

A full life cycle biological clock based on routine clinical data and its impact in health and diseases - Nature Medicine The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

A full life cycle biological clock based on routine clinical data and its impact in health and diseases | Nature Medicine

www.nature.com/articles/s41...

Alzheimer’s disease causes bone marrow myelopoiesis dysfunction Accumulating evidence suggests that both innate and adaptive immunity play crucial roles in combating Alzheimer’s disease (AD). Specifically, enhancing the homing of monocyte-derived macrophages to th...

Alzheimer’s disease causes bone marrow myelopoiesis dysfunction | bioRxiv

www.biorxiv.org/content/10.1...

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function We previously reported that T96K is a gain-of-function mutation in TREM2 based on its ability to increase ligand-dependent activation. Here, we show t…

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

www.sciencedirect.com/science/arti...

Label-free robotic mitochondrial biopsy An automated nanoprobe system performs label-free mitochondrial sampling in living cells.

😮| Label-free robotic mitochondrial biopsy

www.science.org/doi/10.1126/...

Are these the happiest PhD students in the world? Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?

Are these the happiest PhD students in the world?

Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?

www.nature.com/articles/d41...

Transcriptional regulation of disease-relevant microglial activation programs Microglia, the brain’s innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders, and...

Transcriptional regulation of disease-relevant microglial activation programs

www.biorxiv.org/content/10.1...

Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice How can motor function be restored after stroke? This study shows in mice that combining robotic rehabilitation with non-invasive gamma band neuromodulation improves motor recovery by restoring moveme...

Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice | PLOS Biology

journals.plos.org/plosbiology/...

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis

www.nature.com/articles/s41...

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

John Gurdon obituary: Biologist who made cloning possible

He showed that specialized cells retain the genes to form an organism.

www.nature.com/articles/d41...

Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab - Koji Shinoda, Katsuhisa Masaki, Ayano Matsuyoshi, Yuu-ichi Kira, Kazunori Iwao, Eizo Tanaka, Mitsuru Watanabe, Daisuke ... We describe a case of tumefactive demyelinating lesion (TDL) that occurred during B-cell depletion therapy by ofatumumab and discuss its pathogenesis through se...

Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab

journals.sagepub.com/doi/10.1177/...

White matter in focus symposium: Exploring the role of myelin and oligodendrocytes in neurodegeneration Current research is increasingly highlighting the role of oligodendrocytes in neurodegeneration and specifically in dementia. Explore this theme across disease areas in the upcoming symposium White…

WHITE MATTER IN FOCUS SYMPOSIUM: EXPLORING THE ROLE OF MYELIN AND OLIGODENDROCYTES IN NEURODEGENERATION

neuroscience.cam.ac.uk/event-posts/...

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell - NIHR Cambridge Biomedical Research Centre Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the dis...

🚨Scientists have identified a rare brain cell that may drive inflammation in progressive multiple sclerosis (MS)
🔎This important discovery could pave the way for more effective therapies
🔗 For more info: bit.ly/48xJvW1
@cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function Pilat et al. show that the Alzheimer’s disease (AD)-associated gain-of-function mutation, T96K, in the microglial receptor Trem2 reduces levels of soluble Trem2 and Aβ uptake in microglial cells and i...

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

www.cell.com/neuron/fullt...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics

www.nature.com/articles/s42...

Preserving clinical skills in the age of AI assistance How are clinicians to preserve core clinical skills in an era of algorithmic assistance? As artificial intelligence (AI) assumes a growing role in clinical practice, concern is mounting that off-loadi...

Preserving clinical skills in the age of AI assistance

www.thelancet.com/journals/lan...

Scientists Identify Cells Driving Inflammation in Multiple Sclerosis

www.ibt.cas.cz/en/news/Scie...

MRI-based multi-organ clocks for healthy aging and disease assessment - Nature Medicine A new study combines MRI data with proteomic, metabolomic and RNA data to develop and examine seven organ-specific MRI-based aging clocks, uncovering links to overall mortality and organ-specific dise...

MRI-based multi-organ clocks for healthy aging and disease assessment | Nature Medicine

www.nature.com/articles/s41...

Aged mice exhibit widespread metabolic changes but preserved major fluxes Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and ...

Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...

Constructing artificial neurons with functional parameters comprehensively matching biological values - Nature Communications Artificial neurons typically have functional parameters that are mismatched with their biological counterpart. Here, the authors develop artificial neurons that emulate biological neurons in functions...

Constructing artificial neurons with functional parameters comprehensively matching biological values

www.nature.com/articles/s41...

The lipidomic architecture of the mouse brain Lipids are fundamental components of the brain, crucial for synaptic transmission and signal propagation. Altered brain lipid composition is associated with common and rare neuropathologies, yet, the ...

The lipidomic architecture of the mouse brain | bioRxiv

www.biorxiv.org/content/10.1...

Mechanisms of cellular fitness and cell competition: Towards an integrated view Cell competition is a fundamental mechanism of tissue quality control that enables the selective elimination of less fit, mis-specified, diseased or a…

Mechanisms of cellular fitness and cell competition: Towards an integrated view - ScienceDirect

www.sciencedirect.com/science/arti...