Pluchino lab - Regenerative Neuroimmunology

Neuronal synapses are stabilised by activity-dependent vesicular release from oligodendrocyte precursor cells

www.biorxiv.org/content/10.6...

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that im...

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

www.cell.com/cell-metabol...

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses INTRODUCTION Microglia are macrophage-like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derive...

Generation and characterization of iPSC-derived microglia for in vitro modeling of stimuli-specific neuroimmune responses

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

academic.oup.com/nar/article/...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis

www.nature.com/articles/s41...

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

www.pnas.org/doi/10.1073/...

Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance

www.jci.org/articles/vie...

Mitochondrial specialization and signaling shape neuronal function Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need ...

Mitochondrial specialization and signaling shape neuronal function

www.cell.com/trends/neuro...

Dr Luca Peruzzotti Jametti has been appointed as one of two new Early Career Editors for Stem Cell Reports.

✍ The journal is actively seeking applications for the next generation of Early Career Editors. Apply by 13 March 2026.

www.clinical-neuroscience.cam.ac.uk/news/luca-pe...

Check out ISSCR's society journal, Stem Cell Reports!

I am delighted to share that I have been appointed as Early Career Editor for @stemcellreports.bsky.social, the official journal of the International Society for Stem Cell Research @isscr.org! 🔬🌍
I look forward to seeing your research in the field of stem cells!
Submit here: invt.io/1bxb9kpdtfj 👍

EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism Nature Metabolism - EMito-Metrix enables automated evaluation of mitochondrial morphology across species

EMito-Metrix enables automated evaluation of mitochondrial morphology across species

www.nature.com/articles/s42...

Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain The number and diversity of inhibitory neurons (INs) increased substantially during mammalian brain evolution. However, the generative mechanisms of the vast repertoire of human INs remain elusive. We...

Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain

www.science.org/doi/10.1126/...

Spatial Flux Balance Analysis reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

www.nature.com/articles/s41...

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

ER remodelling is a feature of ageing and depends on ER-phagy

www.nature.com/articles/s41...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

www.science.org/doi/10.1126/...

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynami...

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

elifesciences.org/articles/107...

Mito-nuclear communication: From cellular responses to organismal health Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...

Mito-nuclear communication: From cellular responses to organismal health

www.cell.com/molecular-ce...

Mitochondria as sources and targets of cellular signaling Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as bo...

Mitochondria as sources and targets of cellular signaling

www.cell.com/molecular-ce...

Lipoic Acid for Treatment of Progressive Multiple Sclerosis | Neurology Background and ObjectivesA pilot trial of the antioxidant lipoic acid (LA) in secondary progressive multiple sclerosis (MS) demonstrated a reduction in the whole-brain atrophy, suggesting neuroprotect...

Lipoic Acid for Treatment of Progressive Multiple Sclerosis
A Phase 2 Randomized Clinical Trial

www.neurology.org/doi/10.1212/...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis

www.nature.com/articles/s41...

Single-cell proteomic landscape of the developing human brain - Nature Biotechnology Single-cell proteomics maps protein dynamics in the developing human brain.

Single-cell proteomic landscape of the developing human brain
www.nature.com/articles/s41...

Scientists need more time to think | @nature.com

⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍

#CambridgeUniversity #PostdoctoralResearch #JobOpportunity

For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

If you're seeking an exciting opportunity to advance your research career, I highly recommend checking out this postdoctoral position advertised by my colleague @lpjlab.org .org at @camneurodept.bsky.social

Don't miss your chance!

Explore the details here: www.cam.ac.uk/jobs/postdoc...

🚀 Exciting Opportunity Alert! 🚀

The University of Cambridge is seeking a Postdoctoral Research Associate to join
@peruzzotti-123.bsky.social team!

Apply Here cam.ac.uk/jobs/postdoc...

More details on key requirements here www.linkedin.com/feed/update/...

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

REVIEW | E Asimakidou, @lpjlab.org et al. (U Cambridge)

How metabolic interactions between microglia and neurons shape brain health 🧪

Polyamine-dependent metabolic shielding regulates alternative splicing - Nature Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Polyamine-dependent metabolic shielding regulates alternative splicing

www.nature.com/articles/s41...

Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

Heterogeneity, dynamics and organelle interactions of lipid droplets

www.nature.com/articles/s41...

Great fun working on this with the wonderful Evridiki Asimakidou, @pluchinolab.bsky.social and @lpjlab.org‬. l learned so much!🧠