Pluchino lab - Regenerative Neuroimmunology

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

www.eurekalert.org/news-release...

Unusual Brain Cell Type Linked to Progressive MS, Could Point to Therapeutics “Disease in a dish” study indicates DARG cells may be contribute to persistent inflammation characteristic of progressive MS.

Unusual Brain Cell Type Linked to Progressive MS, Could Point to Therapeutics

www.genengnews.com/topics/trans...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science

www.science.org/doi/10.1126/...

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with...

Delighted to see this out in @NeuroCellPress!!!

Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS

www.cell.com/neuron/fullt...

A deep single cell mass cytometry approach to capture canonical and noncanonical cell cycle states - Nature Communications Amouzgar and colleagues present a deep, single-cell mass cytometry approach to capture canonical and noncanonical cell cycle states using protein, phospho-protein, and DNA labelling measurements for high-throughput, multiplexed cell cycle quantification.

A deep single cell mass cytometry approach to capture canonical and noncanonical cell cycle states

www.nature.com/articles/s41...

Engineered neural stem cell vesicles activating Wnt promote blood–brain barrier repair after cerebral haemorrhage Li et al. engineered neural stem cell-derived extracellular vesicles carrying a modified Wnt7a ligand to target the blood-brain barrier (BBB). These vesicl

Engineered neural stem cell vesicles activating Wnt promote blood–brain barrier repair after cerebral haemorrhage

academic.oup.com/brain/advanc...

Data-driven fine-grained region discovery in the mouse brain with transformers - Nature Communications Defining the spatial organization of tissues and organs like the brain from large datasets is a major challenge. Here, authors introduce CellTransformer, an AI tool that defines spatial domains in the mouse brain based on spatial transcriptomics, a technology that measures which genes are active in different parts of tissue.

Data-driven fine-grained region discovery in the mouse brain with transformers

www.nature.com/articles/s41...

Aging: the wound that never starts healing - Nature Communications Aging is a complex process resulting in a decline in organ function. Here the authors proposes that chronic activation of tissue damage response mechanisms drives aging, with aged organs displaying features similar to those seen after acute injury. This provides a unifying framework for understanding the aging process and suggests new directions for treating age-related diseases.

Aging: the wound that never starts healing | Nature Communications

www.nature.com/articles/s41...

Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial The MS-STAT2 trial did not show a treatment effect of simvastatin in slowing disability progression in SPMS. Simvastatin use in multiple sclerosis should be confined to existing vascular indications.

As @Cambridge_Uni PI, I am delighted to have contributed to the @MsStat2 trial on simvastatin for secondary progressive MS.

It highlights the REAL challenges of running efficacy trials in progressive MS.
#ClinicalTrials #ProgressiveMS

www.thelancet.com/journals/lan...

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis

www.science.org/doi/10.1126/...

Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors Márquez-Valadez and colleagues show that neuropsychiatric disorders alter the generation of new neurons in the adult human brain. Major depression, schizophrenia, and bipolar disorder disrupt early st...

Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors

www.cell.com/cell-stem-ce...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects Walsh et al. establish a human forebrain assembloid protocol that supports the derivation of bona fide PVALB+ cortical interneurons and employ it to model schizophrenia in disease-associated structura...

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects: Neuron

www.cell.com/neuron/fullt...

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

A comprehensive genetic catalog of human double-strand break repair | Science

www.science.org/doi/10.1126/...

Artificial intelligence in metabolic research - Nature Metabolism The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

Artificial intelligence in metabolic research | Nature Metabolism

www.nature.com/articles/s42...

Human brain organoids record the passage of time over multiple years in culture The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain devel...

Human brain organoids record the passage of time over multiple years in culture | bioRxiv

www.biorxiv.org/content/10.1...

Aging in mice alters regionally enriched striatal astrocytes - Nature Communications Aging drives distinct molecular changes in the brain. Here, the authors use scRNAseq and MERFISH and find that in mice, aging induces subtype-specific, regionally biased changes in striatal astrocytes, marked by transcriptional repression, inflammation, and impaired neuronal interactions.

Aging in mice alters regionally enriched striatal astrocytes | Nature Communications

www.nature.com/articles/s41...

Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway | PNAS The homeostatic link between the production of mitochondrial ROS (mtROS) and mitophagy plays a significant role in how cells respond to various phy...

Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway | PNAS

www.pnas.org/doi/10.1073/...

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis - Nature An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

www.nature.com/articles/s41...

Feeling inspired and recharged after the EMBO Workshop on Mitochondria in the Nervous System in Engelberg! Thanks to Elisa Motori, Angelika Harbauer, Tatjana Kleele, Julien Courchet, and everyone involved for the fantastic program. Excited for future collaborations!

Can ChatGPT help science writers?

Can ChatGPT help science writers? Not yet ready for “prime time”

www.science.org/content/blog...

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species.

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution | Nature

www.nature.com/articles/s41...

Decoding immune aging at single-cell resolution Advances in single-cell sequencing have transformed our understanding of immune aging by enabling high-resolution dissection of age-associated changes in cellular composition and function. Recent year...

Decoding immune aging at single-cell resolution: Trends in Immunology

www.cell.com/trends/immun...

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

Reprogramming neuroblastoma by diet-enhanced polyamine depletion | Nature

www.nature.com/articles/s41...

The multiomics blueprint of the individual with the most extreme lifespan In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

The multiomics blueprint of the individual with the most extreme lifespan

www.cell.com/cell-reports...

Astrocytes functionally integrate multiple synapses via specialized leaflet domains Volumetric high-resolution electron microscopy reveals thin astrocyte leaflets form gap-junction-interconnected domains that contain minuscule endoplasmic reticulum saccules and enwrap synapses in clu...

Astrocytes functionally integrate multiple synapses via specialized leaflet domains: Cell

www.cell.com/cell/fulltex...

On astrocyte-neuron interactions: Broad insights from the striatum In this review, Khakh discusses the mechanisms, physiology, and pathophysiological relevance of astrocyte-neuron interactions across biological scales from molecules to whole organisms. By highlightin...

On astrocyte-neuron interactions: Broad insights from the striatum: Neuron

www.cell.com/neuron/fullt...

Journals infiltrated with ‘copycat’ papers that can be written by AI Tools such as ChatGPT can be used to generate almost-identical research papers that pass standard plagiarism checks. Hundreds are thought to have been published.

Journals infiltrated with ‘copycat’ papers that can be written by AI

www.nature.com/articles/d41...

Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...

Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties | bioRxiv

www.biorxiv.org/content/10.1...

Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging Oligodendrocyte progenitor cells (OPCs) have the capacity to self-renew, differentiate into mature myelinating cells, and remyelinate the central nervous system in response to demyelination. Normal ag...

Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging | bioRxiv

www.biorxiv.org/content/10.1...

Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial - Nature Medicine Interim trial results of MYR-101, a novel recombinant vector with selective tropism for oligodendrocytes, support its tolerability and indicate improved myelination and reduced cerebrospinal fluid N-acetyl-aspartic acid concentrations in children with Canavan disease.

Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial

www.nature.com/articles/s41...