Krzisch Lab

Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds on FindAPhD.com PhD Project - Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds, listed on FindAPhD.com

A PhD project co-supervised by Dr. Jamie Johnston is available in my lab.

This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.

To know more and apply: www.findaphd.com/phds/project...

Deadline: 07.01.2026, 5pm (UK time)

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake

go.nature.com/3X5lbUg

Dr. Matthew Livesey (main supervisor), Dr. Scott Allen (co-supervisor), I (co-supervisor) and Prof. Dame Pamela Shaw (co-supervisor) are advertising a PhD project on the role of astrocytes in Motor Neuron Disease. It is open to UK and international students.

www.findaphd.com/phds/project...

I am advertising a PhD project on the role of microglia in Parkinson's, using cryoEM and transplantation models. It is open to UK and international students.

www.findaphd.com/phds/project...

Deadline for applications: Thursday 4th December 2025 at 1pm.

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may...

www.nature.com/articles/s41...

Our Master student Abigail King just passed her viva with flying colours. During her stay, she cultured and differentiated hiPSC into microglia before analysing them using immunofluorescence stainings, and made excellent contributions to our lab. She is now looking for a PhD position in the UK.

The Krzisch Lab just received the LEAF Gold award! This award rewards laboratories that take actions to improve their environmental sustainability and efficiency. Our sustainability efforts have allowed us to save a good amount of money as a lab.

krzischlab.wordpress.com/wp-admin/pos...

The Krzisch lab’s website has been launched! Welcome!

The Krzisch lab’s website has been launched! krzischlab.wordpress.com/2025/07/14/h...

University granted Sanctuary status An academic who left his home country of Afghanistan with his wife and young daughter to pursue a new life in the UK has hailed the support from the Sanctuary scholarship scheme as “a window of hope”.

www.leeds.ac.uk/main-index/n...

In the face of anti-science politics, silence is not without cost More scientific leaders need to speak out about anti-science agendas and threats to academic freedom across the world.

www.nature.com/articles/d41...

Vote for your favourite image!  

Reflections of Research is BHF’s annual scientific image competition. Which do you think is the most creative? Like your favourite below, and the image that receives the most likes will be crowned the Supporter’s Favourite!    

Voting closes 25 June.

Role of Microglia in Fragile X Syndrome Exploring the Role of Microglia in Fragile X Syndrome Using an in Vivo Human Induced Pluripotent Stem Cell-Based Model Marine Anais Krzisch, PhD Principal

I am honored to receive funding from the Autism Science Foundation/FRAXA. Our project will explore the role of microglia in Fragile X syndrome, a leading cause of autism and intellectual disability, by transplanting human microglia into mouse brains.

www.fraxa.org?p=38876&prev...

The Krzisch lab just received the LEAF Bronze award! This award rewards laboratories that improve their environmental sustainability. We are now working towards the Silver award.

Here is more information about the LEAF:

www.ucl.ac.uk/sustainable/...

@universityofleeds.bsky.social

The Autism Science Foundation just released a podcast where Dr. Alycia Halladay was joined by I and Dr. Michael Tranfaglia from the FRAXA Research Foundation. We discussed Fragile X syndrome and how microglia, the brain's immune cells, might be a key player in this disorder: lnkd.in/eZfKsHJw

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All Fired Up: Microglial Neuroinflammation in Parkinson’s Disease Parkinson’s disease (PD), the second most common neurodegenerative disorder, has a clear genetic cause in only 5% to 10% of cases. Variants in SNCA, which encodes α-synuclein, are responsible for the ...

I really enjoyed reading the early-career investigator commentary by Dr. Claudia Z. Han (WashU) on our recent paper in Biological Psychiatry: www.biologicalpsychiatryjournal.com/article/S000... . We are indeed planning to follow some of the further research directions that were suggested.

To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.

We found that human microglia that carry a mutation involved in familial Parkinson's disease get more reactive than control when stimulated with an inflammatory component. This suggests that they could worsen neuronal death.

To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.

Microglia are the brain immune cells. In stress or disease conditions, they can get reactive, and this can potentially make them damage neurons.

Our article has now been published in Biological Psychiatry, and one of our pictures made the cover again :)

www.biologicalpsychiatryjournal.com/article/S000...

More diverse investigators could help diversify clinical trials | Cornell Chronicle Black Americans are more willing to participate in medical studies led by Black doctors and researchers, perceiving them as more trustworthy, finds new research co-authored by a Cornell economist.

"Black Americans are more willing to participate in medical studies led by Black doctors and researchers, perceiving them as more trustworthy, finds a new study co-authored by a Cornell economist."

news.cornell.edu/stories/2025...

Postdoctoral fellowship in in vitro human iPS cell-based neurodegenerative disease modeling (274391) | University of Oslo Job title: Postdoctoral fellowship in in vitro human iPS cell-based neurodegenerative disease modeling (274391), Employer: University of Oslo, Deadline: Friday, February 28, 2025

A post-doctoral position is available in the lab of Dr. Kaja Nordengen at the University of Oslo: www.jobbnorge.no/en/available...