Joyce Ohm

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

“I believe he has ideas about becoming a scientist; on his present showing, this is quite ridiculous.”

A privilege to have known John. He always listened to what one had to say with great intent. If you knew him, you know what I mean.
🧪

www.nature.com/articles/d41...

I wrote a really cool grant this week.

Cartoon showing a stick figure looking toward an end goal w/ a bumpy path to it.

Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

new out in Nature www.nature.com/articles/s41...

Megabase-scale human genome rearrangement with programmable bridge recombinases Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...

📣 CRISPR had its day... meet Bridge RNA recombinases from the brilliant Patrick Hsu lab - 3rd Generation Gene Editing is HERE! 🔥🔥🔥🔥🔥🔥🔥 www.science.org/doi/10.1126/...

Compression causes cancer cells to start spreading The switch between proliferation and invasion is triggered by mechanical force.

new out in Nature www.nature.com/articles/d41...

Look at this cute little guy! #lakelife

If you think a golden ballroom is more important than childhood cancer research… I have nothing left to say to you. Please unfollow me.

#pediatriccancer #cancermom

Congratulations. That is so exciting.

Hmmm… so… 1/5 after a 40% budget cut and the starting point was already a 7% payline at NCI. So a payline somewhere around 0.8%? 🤣🤣🤣

This sounds ominous. Do I even want to know?

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop

I learned this week that my MPI prostate cancer disparities R01 will be terminated this September at the end of year 1. Sounds like they are killing the whole disparities NOFO it was awarded under. Sigh… I am not surprised. I just hate all of this.

That’s fine, but it’s still Ohm’s law.

Wow, 7% depressing. In other news, please check your compiled grants in ERA Commons. 129 pages of our P50 missing going between the final preview of submitted Grant in ASSIST to the compiled grant in Commons. No errors. Put in ticket. Fixed. Still 2 pages missing. The NIH is not alright. 🙁

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
🧵

Congratulations!!!!🍾🎊

Buffalo is 99% Midwest. Too much good food and other east coast amenities to completely make the cut.

Epic review on all things cell surface-ome, great resource for the community 🙏

I am enjoying watching 80’s dinner week!

Thank you for being my favorite thing on the internet!

Just had the pleasure of sitting in front of a dental hygienist dispensing medical advice to their seat mate with the confidence of a heart surgeon, pharmacist, and neurologist all rolled into one. Thank God it was only a 1 hour flight. ✈️

The cognitive dissonance required to do (and enjoy) regular fun Friday night things things in the world today is mind boggling. And necessary. Alcohol helps.

Nice job, Mike! It was an important step forward!

Donate to Honor Jordan: Support for funeral expenses., organized by Heather La Forme Jordan’s beautiful and gentle soul was tragically taken from his family, … Heather La Forme needs your support for Honor Jordan: Support for funeral expenses.

For those who want to help.

gofund.me/4abf93f0

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

@mikefeigin.bsky.social you have no idea the power you have on this site. I like one pizza week post from you and now I have an entire feed of pizza photos from around the world. In other news, now I want pizza for breakfast.

I got an email from the SRO yesterday RE: our R01 study section for tomorrow being cancelled. I appreciated it. I’ve never spent this much time obsessively checking ERA commons before a study section. 🤣

Hello Buffalo friends! It’s rally for science time! March 7, 2-6PM, Niagara Square! Sign up below and please spread the word!

www.eventbrite.com/e/stand-up-f...

Congratulations on an amazing score. (I am sorry about all the rest!)