Lawrence Welch

TEM Golgi for @lucygdornan.bsky.social imaged @pasteur.fr
#cryoEM #Golgi #MembraneTrafficking #IwontstaycalmitstheGolgi

Reform UK is proposing a "Britannia card" that would let wealthy foreigners pay a £250k fee to move to the UK, and live here exempt from all tax on their foreign assets

What they don't say: it would cost the UK £34bn

Report here, and thread below: buff.ly/gpe2Dpf

YouTube video by Miran Božičević BBC - Just Another Day - The Seaside (1983)

I am a big John Pitman fan. This episode of his classic series Just Another Day is an utter delight. The CHAOS! It is a fever dream in seaside form.

And directed by one Adam Curtis...

Show this to any American, or anyone really, to explain "the British".

youtu.be/Zb93Ki6nxVM?...

Coventry is doing something that many thought impossible: building a tram line in Britain quickly and cheaply.

Read David Milner of @createstreets.bsky.social on how they've done it and what we can learn from it.

capx.co/coventrys-tr...

Structural basis of DNA recombination catalysis and regulation by phiC31 integrase Large serine integrases catalyse the insertion (integration) and excision of bacteriophage genomes into and from the genomes of their bacterial hosts via site-specific recombination. The recombination...

Our work on phiC31 integrase is now on bioRxiv. Joint University of Glasgow and Research Complex at Harwell effort. Funded by BBSRC. @uofglasgow.bsky.social #researchcomplexatharwell #BBSRC

www.biorxiv.org/content/10.1...

🚨 Membrane Trafficking Seminar 🚨
Two great talks this Thursday!

📆 Thursday, April 24
🕔 5.00PM CET / 11.00AM EST

Hesso Farhan (Innsbruck)
Mechanosensing at the ER

Kelly Ten Hagen (NIH)
Secretory granule biogenesis in vivo

Details at
felixcampelo.wixsite.com/membranetraf...

Mark Zuckerberg’s new house has strong “we won a five year planning battle with Alderley Edge council for permission to demolish the bungalow that used to stand here” vibes.

On April 19, 1898, Camillo Golgi described what we now know as the #Golgi apparatus - a structure so pretty and unusual it took over fifty years for the scientific community to agree it wasn’t just an artefact.
April 19 is #GolgiDay! Mark your calendars to honour the best organelle.

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...

Fascinated by the different stock pictures of dogs that various outlets have gone for to illustrate this story.

Out now in The EMBO Journal: Our collaborative new #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh

Lawrence Welch on LinkedIn: My retirement from the bench This year, I have been on a journey. Not a journey that requires a car, train or plane; but rather a journey inward. Read here why I have made the decision to…

This year, I have been on a journey. Not a journey that requires a car, train or plane; but rather a journey inward. Read here why I have made the decision to retire from the bench.

www.linkedin.com/posts/lawren...

One of my favourite tweets about academia

Everyone saying “no we can’t let the NHS use a proper joined up digital patient database, it’s all part of a plot to privatise British healthcare and sell your data” should be forced to read the dozens (hundreds?) of case studies like these www.bbc.co.uk/news/health-...