Hannelore Longin's Avatar

Hannelore Longin

@hannelorelongin.bsky.social

PhD student @ Computational Systems Biology & Lab of Gene Technology. Investigating PTMs in viruses and bacteria with bioinformatics πŸ’»πŸ¦ 

98 Followers  |  121 Following  |  3 Posts  |  Joined: 19.11.2024  |  1.4894

Latest posts by hannelorelongin.bsky.social on Bluesky

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Protein Structure Informed Bacteriophage Genome Annotation with Phold Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n

www.biorxiv.org/content/10.1...

08.08.2025 07:10 β€” πŸ‘ 131    πŸ” 65    πŸ’¬ 5    πŸ“Œ 3
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Synteny-aware functional annotation of bacteriophage genomes with Phynteny Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...

🚨 New preprint 🚨

My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky

www.biorxiv.org/content/10.1...

30.07.2025 06:00 β€” πŸ‘ 83    πŸ” 42    πŸ’¬ 4    πŸ“Œ 1

Curious about our findings and where we're headed? Happen to be at #ISMB2025 ? Come check out
my poster (A-229, function COSI) today!

21.07.2025 06:51 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...

πŸ“£ New preprint alert!

Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.

πŸ“„ doi.org/10.1101/2025...

21.07.2025 06:51 β€” πŸ‘ 41    πŸ” 17    πŸ’¬ 1    πŸ“Œ 0

We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social

07.07.2025 08:49 β€” πŸ‘ 13    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
FLAMS – Find Lysine Acylations & other Modification Sites

Hip hip hooray: our #PTM conservation tool FLAMS turns 1 πŸŽ‚

To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.

Come check it out @ tinyurl.com/flamsweb & let us know what you think!

28.01.2025 08:55 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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1/11 - With Karin Mitosch and ClΓ©ment Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...

23.12.2024 07:29 β€” πŸ‘ 37    πŸ” 16    πŸ’¬ 1    πŸ“Œ 2

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