Adaptive Therapy
Abstract. A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy frequently fails due to emergence of re...
Of course, the original idea of Adaptive Therapy was from the visionary Robert (Bob) Gatenby at @moffittnews.bsky.social. His seminal paper:
aacrjournals.org/cancerres/ar...
& lots of work since, with the epicentre being @sandyanderson.bsky.social's Centre at @moffittnews.bsky.social
02.05.2025 12:58 — 👍 2 🔁 1 💬 0 📌 0
In other words - remarkably - it could be that less drug, less often leads to better outcomes for some patients with ovarian cancer.
We eagerly await the clinical trial results - they will be definitive.
02.05.2025 12:52 — 👍 3 🔁 1 💬 2 📌 0
Delighted that a major project of my post-doctoral fellowship in the de Bono lab has been published. A really interesting story, featuring the likes of @icrlordlab.bsky.social @boragurel.bsky.social among many others at @icrlondon.bsky.social and elsewhere.
05.12.2024 20:24 — 👍 11 🔁 5 💬 1 📌 0
Frequent evolution of BRCA2 reversion mutations during PARPi treatment in prostate cancer
22.11.2024 09:29 — 👍 2 🔁 0 💬 0 📌 0
Welcome to #bsky @alejandrapcelab.bsky.social ! Alejandra Bruna leads the paediatric cancer evolution (PCE) lab here in our @cec-icr.bsky.social. Focusing on dissecting the role of phenotypic plasticity in childhood cancer evolution and therapy response.
21.11.2024 14:58 — 👍 0 🔁 0 💬 0 📌 0
