@temt-icr.bsky.social
Target Evaluation & Molecular Therapeutics lab at the Institute of Cancer Research, London. Unironically passionate about target validation π― and drug discovery π in oncology.
Charity-funded research is a cornerstone of innovation in our universities β but it needs the right support to thrive.
Ahead of the #Budget, our Advocacy Manager, @ollierichards.bsky.social, shares whatβs needed to keep the Charity Research Support Fund strong.
Read more ‡οΈ
www.icr.ac.uk/crsf-blog
Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.
01.07.2025 05:48 β π 11 π 2 π¬ 0 π 0
Unfinished Symphony
@icr.ac.uk @temt-icr.bsky.social
youtu.be/yjelh9iQWMA?...
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
Five people at a restaurant table, looking in to the camera and smiling.
Great day & night discussing how to design impactful drugs π with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers π»!
11. The Authority Gap by Mary Ann Sieghart.
Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap
The timing on this is perfect π as the #TEMTiversary merch arrived today! We are branded 𧬠π!!
02.06.2025 11:11 β π 3 π 0 π¬ 0 π 0
Capivasertib given to breast cancer patients in Wales for first time
01.06.2025 21:22 β π 4 π 3 π¬ 0 π 0LOL
02.06.2025 09:30 β π 0 π 0 π¬ 0 π 0Does it have a swear word in it?
02.06.2025 08:55 β π 0 π 0 π¬ 1 π 0
A logo with TEMT and our team name. It has a strand of DNA and a drug capsule.
Official one here π (only took us 10 yearsβ¦)
02.06.2025 08:40 β π 0 π 0 π¬ 0 π 0
A kinda symmetrical logo that reads TEMT forward and TMET if you turn it upside down. It has a drug capsule and a strand of DNA, consistent with our lab name.
Decided to celebrate lab anniversary by reenergising our social media & sharing lab highlights every day in Juneβ¦and forgot on the very 1st day π«
Anyway, itβs our 10th anniversary & weβve got a new official (see bio) and unofficial logo π; the latter has a story, b/c of course it doesβ¦ #TEMTiversary
Happy #InternationalClinicalTrialsDay! π
At DDU-IIT @icr.ac.uk , weβre proud to help turn cutting-edge science into real-world impact. π¬π
To the patients, families & teams behind every trialβyour courage fuels the future of medicine. β€οΈβπ₯
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP
In June, we are having 5-yr external scientific review & the lab celebrates 10-yr anniversary π! Both good things, but prep has me reflectingβ¦a lot. My time at the ICR is almost perfectly bisected by the pandemic & the two halves feel like different life times. Literally The Before Timesβ’οΈ & After.
21.05.2025 06:34 β π 4 π 0 π¬ 0 π 0A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
02.05.2025 08:51 β π 3 π 2 π¬ 0 π 0
A graphic with a photo of Clare Isacke smiling to camera. The text reads: #AACR25 Educational Session: Clare Isacke. The Institute of Cancer Research.
Get up to speed with the cancer dormancy field.
Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.
#AACR2025 | @icr.ac.uk
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky π§ͺ
doi.org/10.1038/s414...
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
19.03.2025 07:43 β π 10 π 2 π¬ 0 π 0
π‘ Thinking about a PhD?
β¨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.
Register now π humantechnopole.it/en/trainings... #phdlife
Recruitment brochure featuring a picture of our Centre for Cancer Drug Discovery and the same web address from the main post.
π¨Weβre recruiting!π¨
Looking directly at my oncology drug discovery biology folks π
3οΈβ£ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, youβve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
π£ Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 πππ
π World-class Speakers
π Cutting-edge Insights
π Networking Opportunities
π
Date: 21st March 2025
π Location: GSK Stevenage, UK
π Register here: www.smr.org.uk/Meetings/202...
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
31.01.2025 11:54 β π 5 π 2 π¬ 0 π 0
Recruitment brochure featuring a picture of our Centre for Cancer Drug Discovery and the same web address from the main post.
π¨Weβre recruiting!π¨
Looking directly at my oncology drug discovery biology folks π
3οΈβ£ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, youβve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact
We were delighted to host Shadow Secretary of State for Science, Innovation & Technology, Alan Mak MP at our Chester Beatty Labs last week π
We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology π§΅
#CancerResearch
A large round (frankly English) apple pie. Two mugs of coffee and a knife sit next to it on a conference room table.
Happy Pi Day ! Our lab has a long and frankly sit-com quality relationship with Pi Day due to the inevitable date confusion when I moved to the UK π¬π§. Yes, we also celebrate on 22 July as the closest fractional approximation of pi, why do you ask?
View from lab meeting this morning π₯§ βοΈ π
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites π) www.nature.com/articles/s41...
05.03.2025 14:44 β π 34 π 11 π¬ 2 π 0
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers donβt understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
12.03.2025 06:44 β π 14 π 2 π¬ 0 π 0
π What an exciting day! For a whole day, the children of HT employees became little scientists and learned so much about lab safety, blood and the immune system, water and more.
π The future of science is in their hands!
The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more:Β buff.ly/8a8WUn9 #AACRFellows
10.03.2025 14:09 β π 35 π 3 π¬ 1 π 11
Weβre hiring! Fancy working on cutting edge mouse models and single cell and spatial phenotyping to understand the evolution of therapy resistance in breast cancer? Join us! jobs.icr.ac.uk/vacancies/11...
07.03.2025 21:13 β π 4 π 3 π¬ 0 π 0
