Daniël P Melters

Epigenetics Society Special Symposium 2025 | Epigenetics Society
Our exciting conference on epigenetics will be held in Chicago, Oct. 15- 17, 2025. We have an outstanding set of 7 Keynote Speakers. www.esconference25.com/events/epige...

Single-Molecule Studies with AFM and High-Speed AFM: From Nucleosomes to Chromosomes Atomic force microscopy (AFM) is a single-molecule imaging technique invented in 1985. Development of high-speed AFM (HS-AFM) in 2001 now allows for the direct visualization of the dynamics and kineti...

Interested in studying #nucleosomes, #chromatin, or #chromosomes at the single molecule level, atomic force microscopy (#AFM) is easy to use technique. Here is a great methods paper to guide you through the whole process. Big thanks to Keir Neuman and Yamini Dalal.

link.springer.com/protocol/10....

It’s a honor to see my first cover ever. Thank you to the co-authors, reviewers, and editors.

www.life-science-alliance.org/content/8/4/...

You are missing the gem of a last point if you do decide to reply.

A card that a 6-year-old made this weekend for an NIH employee.

a poster that says if life gives you lemon make lemonade on it ALT: a poster that says if life gives you lemon make lemonade on it

ATTENTION (PLEASE SHARE)

If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.

There are lots of talented and accomplished people who may be looking for new opportunities.

Our latest work. We identified two structurally distinct CENP-A nucleosomes at the centromere. One is associated with the CCAN and both are important for regulating centromeric transcription.

Our latest work is now online.

I’m sorry to hear about the lost samples. That’s terrible.

Not being helped bc any of the other shenanigans.

Centromere inactivation during aging can be rescued in human cells Sikder et al. uncover how centromere function is depleted during human aging. They report reduced CENP-A/C levels and centromeric transcription in aged cells. Using knockdown approaches, they identify...

The latest work from the Dalal lab. @sweta_sikder and co show how p53, CENP-B, and LSD1 can help rescue CENP-A and CENP-C levels in aged cels.

www.cell.com/molecular-ce...

Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs Chromatin architecture governs DNA accessibility and gene expression. Thus, any perturbations to chromatin can significantly alter gene expression programs and promote disease. Prior studies demonstra...

I’m proud to have contributed to this beautiful work by Yvonne Fondufe-Mittendorf lab, a project led by now Dr. Wesley Saintilnord and co — Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs www.biorxiv.org/content/10.1...