Clemens Mauksch (he/him)

Ich habe das ungute Gefühl, dass das keine Konsequenzen haben wird. #Gießen #GI2911

Die Polizei ist komplett entfesselt! Sie kennt keine Zivilisation mehr: Schädel-Hirn-Trauma, offene Brüche, sehr viele Krankenwagen danach. Die Polizei ENTZIEHT den friedlichen Demonstrierenden sogar den Schutz. So ist ein Auto in eine Menge gefahren!
Das Ganze muss ein Nachspiel haben!

Doctoral hat surrounded by icons representing genome science fields: math, bioimaging, genomics, bioinformatics & more. Logos for Uni Göttingen, GönomiX & IMPRS-GS.

Want to shape the future of genome science? 🧬 PhD positions available at Max Planck Institute & Uni Göttingen (IMPRS-GS/GönomiX)! Join a vibrant, interdisciplinary research community. Apply by Jan 14, 2026: www.uni-goettingen.de/de/applicati... #GenomeScience #Research

This is misinformation by default, so if you're a journal and you use AI slop for your cover or your announcements, you're not scientific in any way and should be shamed mercilessly 🧪

🧬 PhD Position: Evolutionary & Comparative Genomics 🕷️
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics

Very excited to present OpenCGChromatin🔥🔥🔥

A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation

Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

POV: you are a young woman celebrating a recent academic success

🧬 10 @dfg.de-funded PhD positions at @goettingen-campus.de 🧬
❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians).
💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging.
📌Start: June 2026.
#EvoDevo #Genomics #Bioinformatics

Tumblr-Post: exwife-of-frankenstein Yesterday Youtube is full of ads, spotify is full of ads, tumblr is full of ads, pinterest is full of ads. Everything uses ai. Every new update makes the website/app worse. Youtube auto translates almost every video I want to watch. Sometimes pinterest only loads ads for me. Check out this new ai feature. Here's a new update that breaks ur phone. Why are u complaining about ur phone, just get the newest iphone lol. Join my patreon. Join my membership. Pay a monthly membership to get all features. Upgrade your membership to get even more features. Subscribe to netflix. Subscribe to disney. Subscribe to amazon. Subscribe to hulu. This content isn't available in ur country. This content was removed. This website was removed. This feature only exists for apple. U need a WiFi connection to play this game. This app only exists for apple. U need an account. We need your email to finish creating an account. We need your number to finish creating your account. We need your id to finish creating your account. In order to delete your account please write an email. In order to delete your account you need a laptop. Oops our database was hacked and ur information was stolen. Ur data was sold from this random website u used 10 years ago. Spam call. Spam call. Spam call.

The Closing Scientific Retreat of @spp2202.bsky.social is under way in Goettingen with Gerd Blobel delivering the first Keynote lecture on LDB11-mediated looping of chromatin.

📢 Last days to apply for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...

Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

JD Vance claims that diversity weakens unions, as people end up distrusting each other and not organizing.

Let me tell you two menswear stories related to this claim. 🧵

Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....

Happy to report that the first part of my PhD work is published! Thank you to everyone involved!

"Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research"

Frequently the trans and intersex communities are excluded from population-based genomics studies because they cannot be put in a neat box. But sex is a complex trait, like many other traits we study #ASHG25

Deutsche Hunger Games

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

Neues Polizeigesetz in Berlin: „Abkehr von der grundrechtsfreundlichen Politik“ Die schwarz-rote Berliner Landesregierung bastelt an einem neuen Polizeigesetz, das mehr Videoüberwachung, Staatstrojaner und viele weitere Befugnisse für die Polizei bereit hält. Dafür gab es…

Gesetzesnovelle von 700 Seiten: Grundrechtsfreundliche Politik vorbei. Nun biometrische Massenüberwachung & #Staatstrojaner für Polizei Berlin netzpolitik.org/2025/neues-p...

How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

✨Exciting news: the main story of my PhD is out in Science!

Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.

📖 Read the full story here: www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

www.science.org/doi/10.1126/...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...

Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...

Grafik, welche die Entwicklung der Vermögensverteilung in Deutschland seit 2010 zeigt. Der Anteil des Vermögens der oberen zehn Prozent am Gesamtvermögen steigt kontinuierlich an. Aktuell besitzen die oberen zehn Prozent der Bevölkerung 11,4 Billionen Euro, die unteren 50 Prozent lediglich 0,48 Billionen Euro (Stand: 1. Quartal 2025, Quelle: EZB).

In kaum einem Land ist Vermögen so ungleich verteilt wie in Deutschland. Die reichsten zehn Prozent der Bevölkerung besitzen sagenhafte 11,4 Billionen Euro – und werden immer reicher. Sparen aber will die Regierung bei den Ärmsten.
www.t-online.de/nachrichten/...

PhD position in Gene Regulation Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...

Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing

Full story & movies👇

YouTube video by SWR Wissen Was ihr noch NICHT über den Eisprung wusstet! | SWR Wissen

Tabea Marx from the Department of Meiosis @schuhlab.bsky.social talks about the group’s ovulation research in the new SWR Wissen video (in German)! Why is ovulation research so challenging for scientists? What did the team find out? Watch the video to learn more👇
www.youtube.com/watch?v=UDz-...

Oscillatory pattern of chain extension and nucleosome self-association with variation in protein-free DNA linker length in simulated nucleosome-decorated DNA chains. Regular structures bearing 15 nucleosomes constructed from the mean rigid-body parameters between successive base pairs; nucleosomal cores depicted as wedge-shaped objects and color-coded to highlight the two- and three-start organization of the structures. Nucleosomal DNA constrained to the 147-bp pathway found in the best-resolved core particle structure, pdb_id 1kx5

Distortions in the average structures of simulated nucleosome-decorated DNA chains introduced by changes in the positioning of a singe nucleosome. A. Local opening and unpacking of a compact array introduced by a single 2-bp increment in the spacing between nucleosomes. B. Kinking of an extended array by a single 5-bp increment in nucleosome spacing.

Effects of the nucleosomal DNA pathway on the average configurations of simulated 12-nucleosome arrays. Average structures bearing the undertwisted DNA found in the best-resolved core particle structure, pdb_id 1kx5, compared to the overtwisted DNA found in the RCC1-nucleosome complex, pdb_id 3mvd. The regulatory protein is not included in the simulations. Upper views looking perpendicular to the chromatin axis and lower views down the axis

Molecular 'snapshots' illustrating the potential effects of chain length and nucleosome positioning on large-scale chromatin folding. A. Smoothly deformed array of 78 nucleosomes with uniform 177-bp spacing. B. 77-nucleosome chromatin 'copolymer' containing three stretches of nucleosomes with different spacings: a compact array of 26 nucleosomes (deep brown) with 172-bp spacing at the 5́-end of the chain; an extended array of 26 nucleosomes (light brown) with 177-bp spacing in the middle; an opened array of 25 nucleosomes (yellow) with 207-bp spacing and a nucleosome-free gap at the 3́-end of the chain. Note the more pronounced junction between ‘helical’ stretches when the spacing changes by roughly a half turn of DNA (172 – 177 = –5 bp) than when altered by a multiple of the double-helical repeat (207 – 177 = 30 bp). The presence of a nucleosome-free gap, within the stretch of nucleosomes spaced at 207-bp intervals, enhances the flexibility of the modeled structure, allowing the chain to bend in various directions

Contributions of local structural and energetic features of DNA to large-scale genomic organization [perspective by Wilma Olson & Co) www.sciencedirect.com/science/arti...

MLL2 facilitates long-range gene regulation through LINE1 elements Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...

#Preprint alert! 📣

We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements

www.biorxiv.org/cgi/content/...

Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression

www.biorxiv.org/content/10.1...