Lewis Taylor

Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.

17.07.2025 11:54 — 👍 21    🔁 8    💬 1    📌 0

'People think my wife is drunk but she's living with a rare brain disease' Edinburgh couple hope for treatment for rare neurological condition progressive supranuclear palsy.

See a lovely piece on STV highlighting the impacts of this disease on families . While our new findings will not lead to a new treatment today, we aim to bring hope to people living with PSP for the future news.stv.tv/east-central...

17.07.2025 11:56 — 👍 8    🔁 6    💬 0    📌 0

📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.

Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠

16.07.2025 13:10 — 👍 11    🔁 4    💬 0    📌 1

Amazing work by the Booker lab here in Edinburgh! Another demonstration of the power of live human brain tissue 🧠.

07.05.2025 08:21 — 👍 2    🔁 1    💬 0    📌 0

Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...

What, what! We just published our work studying GABAB receptors in human and rat brain.

www.nature.com/articles/s41...

07.05.2025 07:27 — 👍 22    🔁 8    💬 2    📌 2

The Resilient Mind: Fighting Against Dementia Join us for an insightful event exploring the fascinating world of the brain. The first talk dives into the science of neurodegeneration, where brain cells…

Curious about how the brain might adapt to neurodegeneration? Come hear me talk about gold, guns and brain cells at @pintofscience.uk in Edinburgh! 🧠🍻 #pint25

14.04.2025 10:30 — 👍 21    🔁 11    💬 0    📌 0

Thanks for the support @pichaelmichael.bsky.social !

30.04.2025 18:44 — 👍 1    🔁 0    💬 0    📌 0

Fantastic coverage of our recent work using living human brain slices to study Alzheimer’s disease from @itvnews.bsky.social

www.itv.com/news/2025-04...

30.04.2025 15:38 — 👍 13    🔁 4    💬 0    📌 0

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures - Nature Communications Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects...

Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...

30.04.2025 12:02 — 👍 38    🔁 12    💬 0    📌 0

Grateful for the chance to share my work at #BNA2025 yesterday 🧠 Loved all the insightful chats and feedback I received! @britishneuro.bsky.social @alzheimersresearchuk.org

30.04.2025 09:14 — 👍 12    🔁 2    💬 1    📌 0

Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.

01.04.2025 08:18 — 👍 27    🔁 11    💬 2    📌 1

No eating accidents here it’s all calculated 📈

31.01.2025 14:29 — 👍 2    🔁 0    💬 0    📌 0

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

We just published a thing!
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.

www.nature.com/articles/s41...

07.01.2025 10:22 — 👍 32    🔁 15    💬 1    📌 1

Paper acceptance mornings are the best!!!!! :) Watch this space 💃🏽💃🏽💃🏽

08.01.2025 10:27 — 👍 24    🔁 1    💬 0    📌 0