Jorge Iván Castillo-Quan

Altered translation elongation contributes to key hallmarks of aging in the killifish brain Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the...

Congratulations to our new postdoc Domenico DiFraia for his amazing paper in @science.org! 🥂 A tour de force on brain aging in the killifish. 🐟 Transcriptomics, proteomics, including ribosome profiling, PTMs, etc... Translation is key for understanding brain aging!🧬🎉
www.science.org/doi/10.1126/...

02.08.2025 08:41 — 👍 11    🔁 4    💬 0    📌 1

Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc

Different from prior connectomes - it is brain + cord (think spinal cord)

We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...

02.08.2025 14:30 — 👍 52    🔁 23    💬 2    📌 2

Nonuniversality of inflammaging across human populations - Nature Aging Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...

Nonuniversality of inflammaging across human populations
www.nature.com/articles/s43...

02.07.2025 12:15 — 👍 7    🔁 3    💬 0    📌 0

Very excited to share this Nature Comms publication: "Enhancing autophagy by redox regulation extends lifespan in Drosophila". From @cochemelab.bsky.social et al @imperialcollegeldn.bsky.social @ucl.ac.uk @mpiage.bsky.social. Congrats to all involved! #Redox #aging www.nature.com/articles/s41...

30.06.2025 18:58 — 👍 5    🔁 2    💬 1    📌 0

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila.
doi.org/10.1038/s414...

27.06.2025 12:32 — 👍 7    🔁 2    💬 0    📌 0

Project led by ⭐ #postdoc Claudia @claudialennicke.bsky.social and featuring a #collaboration with Linda Partridge 🪰⏳
Thanks to all our colleagues for their valuable contributions! #TeamScience @castilloquan-ji.bsky.social @lucievleeuwen.bsky.social @andreafoley.bsky.social @mitoredox.bsky.social

27.06.2025 11:21 — 👍 4    🔁 1    💬 0    📌 0

Last month I had the great privilege of presenting my work in this Lecture Hall at the Joslin Diabetes Center for the last time. The research labs at Joslin are moving to the Center for Life Science building. Looking forward to new memories in Joslin’s new home… pics to come.

09.04.2025 17:18 — 👍 1    🔁 0    💬 0    📌 0

WORKING LIFE Four lessons for being a great mentor to undergrads. Illustration shows two individuals walking through darkness, one using a flashlight that shines a light on various symbols

"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj

26.01.2025 15:07 — 👍 157    🔁 43    💬 1    📌 6

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

18.12.2024 22:40 — 👍 297    🔁 97    💬 22    📌 12

A list of the number of chromosomes of ten different organisms…

Fruit fly = 8
Housefly = 12
Snail = 24
Frog = 26
American badger = 32
Red fox = 34
Cat = 38
Dolphin = 44
Human = 46
Pineapple = 50

* I, for one, welcome our future pineapple overlords

19.12.2024 10:03 — 👍 13082    🔁 1260    💬 558    📌 152