Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study This study found important regional differences in AKI severity, phenotype, management, and outcomes in patients with decompensated cirrhosis. Health-care coverage remains an important driver of survi...

📣 ICA GLOBAL AKI study published in @lancetgastrohep.bsky.social

🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality

🎯Need for equitable & standardized care

www.thelancet.com/journals/lan...

Always a pleasure to hear from @eddievl.bsky.social and what a treat you have him at WashU IBD symposium.
#gisky #medsky

First IBD symposium at @washumedrheum.bsky.social kicks off with thought-provoking method of treatment ➡️ stem cell transplant. @mountsinaigi.bsky.social
#gisky #medsky

🔥Nivolumab and Ipilimuma approved by EMA for advanced hepatocellular carcinoma 🔥
👇https://ec.europa.eu/health/documents/community-register/html/h1014.htm
👉great news for our patients > more options in 1st line
😅amazing: approval in 🇪🇺by EMA before 🇺🇸by FDA
@myESMO @EASLedu @ILCAnews #livertwitter

🔥off the press
Precision surgery for hepatocellular carcinoma
@LancetGastroHep
doi.org/10.1016/S246...
👉the field is moving to precision medicine
👉Our thoughts on current strategies & future opportunities > team work is key for personalized therapy
@myESMO

Pregnancy and the liver

1. Comorbid disease
2. Liver disease caused by pregnancy
3. Drug safety
4. Ongoing trials

@thelancet.bsky.social

doi.org/10.1016/s014...

Why Should We Prescribe Medications to Treat Alcohol Use Disorder? | AASLD The prevalence of alcohol-related liver disease (ALD) is increasing. Still, f ew gastroenterology (GI) and hepatology providers are prescribing medications to...

Fantastic 📰 @liverthedream.bsky.social

✨ALD is📈prevalent!
✨Abstinence from🍸🍺 is the ONLY available tx to 🛑 progression of 🍸-related injury
✨#liversky MUST🪜up to treat AUD, 💊 are safe➕ effective

@rbataller.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social

www.aasld.org/liver-fellow...

Advances in liquid biopsy: From exploration to practical application
@Cancer_Cell
doi.org/10.1016/j.cc...
👏Excellent review on liquid biopsy
👉LP will be key for disease monitoring and to understand resistence mechanisms
@myESMO

Liver metastases do not predict resistance to the addition of atezolizumab to FOLFOXIRI + bevacizumab in proficient MMR mCRC
@ESMO_Open
doi.org/10.1016/j.es...
🔎 Post-hoc AtezoTRIBE study
👉LM prognostic, not predictive
🧐Do we need to rethink LM & ICI efficacy in mCRC?
@myESMO

Aptamer-directed, nanovesicle-mediated targeting of... : Hepatology ranscriptome-targeting therapeutics. Approach & Results: Milk-derived nanovesicles (MNVs) were loaded with short interfering RNAs targeting YAP, the downstream effector of the Hippo pathway; LCK, a...

Aptamer-directed, nanovesicle-mediated potentiates chemosensitivity in 2 cholangiocarcinoma models.
#liversky #oncsky #sciencesky

journals.lww.com/hep/abstract...

Long-term liver outcomes after metabolic surgery in compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis - Nature Medicine In individuals with obesity and compensated metabolic dysfunction-associated steatohepatitis-related cirrhosis, metabolic surgery was associated with a lower risk of major adverse liver outcomes, comp...

Among patients with compensated MASH cirrhosis and obesity, metabolic surgery was associated with an 80% lower risk of progression to decompensation
#liversky #medsky

www.nature.com/articles/s41...

NIH slashes overhead payments for research, sparking outrage Move to cut indirect cost rate to 15% could cost universities billions of dollars

“This is a surefire way to cripple lifesaving research and innovation."
#sciencesky #medsky

www.science.org/content/arti...

Mismatch repair andMSI phenotypes across solid tumors: A comprehensive cBioPortal study on prevalence & prognostic impact
European Journal of Cancer
doi.org/10.1016/j.ej...
🔎🗺️RWD, 23.893 pts
👉MMR-m status not associated with MSI in 48.9 % of cases
🧐need of comprehensive testing

Atezolizumab Plus CTx With or Without Bevacizumab in BTC
🔎 Clinical & Biomarker Data From Phs II IMbrave151 Trial
@JCO_ASCO
👉ORR 26 vs 26%
👉mPFS 8.3 vs 7.9 mo
👉mOS 14.9 vs 14.6 mo
👉High VEGFA may be a predictive biomarker
🧐❌trail, not sure whether to proceed...

The Brain-Gut-Microbiome Axis Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and inte...

🏅Top downloaded article CMGH

📞3-way call b/t your brain, gut & microbiota!

🦠Gut microbes talk via nerves, hormones & immune signals
🧠The brain shapes gut microbiota & function
✂️Cuts to these calls influence IBS, obesity & neuro disorders

#GIsky

www.cmghjournal.org/article/S235...

Hemodynamic profile of terlipressin and octreotide in patients with cirrhosis and portal hypertension: A randomized, single-blind clinical trial Continuous infusion (CI) of terlipressin may result in a more sustained reduction in portal pressure with fewer adverse effects than administered as a bolus. This study aimed to compare the hepatic an...

No significant reduction in HVPG with terlipressin use, but CO and HR significantly decreased. #liversky @jhepatology.bsky.social

www.jhep-reports.eu/article/S258...

Hiring Alert!

We’re looking for a fellow to join our lab at @Stanford_GI and work on cutting-edge research in liver cancer immunobiology.

Help me spread the word, know someone interested? Send them my way! #HCC

postdocs.stanford.edu/prospective/...

🔥off the press
Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data
@JHEP_Reports
doi.org/10.1016/j.jh...
👉Many trials in 1st line BTC, but not much progress
🤨we need to do better
@myESMO @EASLedu

Figure 3. Seroprotection Response to the Hepatitis B Vaccine by Scheduled Study Weeks

Both a 2-dose and a 3-dose hepatitis B vaccine with a cytosine phosphoguanine adjuvant showed a superior seroprotection response compared to 3 doses of the conventional HepB-alum vaccine.

➡️ ja.ma/40A6EBf

#MedSky

Head‐to‐Head Comparison Between Phosphatidylethanol Versus Indirect Alcohol Biomarkers for Diagnosis of MetALD Versus MASLD: A Prospective Study Using a well-phenotyped prospective cohort with systematic assessment through MRI-PDFF, MRE, and PEth testing, this study demonstrates that PEth is an accurate, quantitative, objective alcohol biomar...

💡PEth gets another win!

Compared to previously used non-invasive tests in differentiating MetALD from MASLD

#liversky

onlinelibrary.wiley.com/doi/abs/10.1...

How Our Gut Microbiome Can Drive Sugar Cravings More Evidence for Our Gut Taking Center Stage for What We Eat

We ought to change "sweet tooth" to "sweet gut"! erictopol.substack.com/p/how-our-gu...

Akero Therapeutics Reports Preliminary Topline Results Showing Statistically Significant Reversal of Compensated Cirrhosis (F4) Due to MASH—by Both Completer and ITT Analyses—at Week 96 in Phase 2b SY... Among patients with baseline and week 96 biopsies, 39% of the 50mg EFX group (p=0.009) demonstrated ≥1 stage improvement in fibrosis with no worsening of...

Significant Reversal of Compensated Cirrhosis (F4) Due to MASH
#LiverSky #MedSky

www.globenewswire.com/news-release...

CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

Nature research paper: CD45-PET is a robust, non-invasive tool for imaging inflammation

https://go.nature.com/4jmStIF

When my patients show up with accessories that make my day...

#goals #medicine

Love the logo!

Utility of methylated DNA markers for the diagnosis of malignant biliary strictures
doi.org/10.1097/HEP....
@HEP_Journal
👉identification of malignant biliary strictures is challenging
👉Bile can be valuable for NGS & methylated DNA markers
@myESMO @EASLedu @ILCAnews #livertwitter @curecc

Concerned about Hepatitis B reactivation? New guidelines @amergastroassn.bsky.social 👇🏼

#liversky #medicine

It only seems fitting to start my post series @bsky.app with a positive note.
Transplant Hepatology BOARD CERTIFIED! 🥳🥳
Looking forward to interacting with all of you here on #medicine #science and a sprinkle of #sports