Philip Ahern

Aha, that fits.

Or love it, so they don't want it treated?!

I don't understand the basis of the NIDDK cut. Surely it fits the newly stated mission re chronic diseases/"out diet is killing us" quite well. Awful is right.

Attending #BSI25? 📣 Meet our Editor-in-Chief, Simon Milling!

Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Discovery Immunology. Come say hello! 👋

Eh, does anyone know why bovine serum albumin (from Sigma at least) has tripled in price?

Interesting 🧵. IANAE so won’t comment on the science beyond noting that phase separation (in biology) is highly contentious (see e.g. genesdev.cshlp.org/content/33/2...). But it does bring up issues around publishing and editorial decisions 1/n

Populist Dems won. Moderate Dems won. We won in blue states. We won in purple states.

Maybe the take is that (a) people think Trump is out of control; and (b) people like Dems when we're taking a stand and fighting for what we believe in - as we have been for the last month.

Love Nebraska so much, these lines always give me the chills:

"Now my ma she fingers her wedding band
And watches the salesman stare at my old man's hands
He's tellin' us all 'bout the break he'd give us
If he could but he just can't
Well if I could I swear I know just what I'd do"

2/2 So, some TCR may be more prone to become Tregs or whatnot, but without tracking responses to the same epitope for different TCR it's really hard to know if there is TCR determinism (which I have no issue with) versus some facet of the stimulation (loosely "environmental") that drives this.

1/2 This is a very nice paper but I'm not sure I agree fully with the conclusion (reading on the train on my phone, may have missed something). To my mind, this data shows that a given TCR will repeatedly adopt a particular cell fate when encountering the same antigen derived from the same source.

Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

Was it ever alive? I joined because I heard it was like old Twitter but I never see much in the way of decent science conversation on here. Maybe people have just abandoned social media.

It's more than 20 years old, so obviously doesn't discuss many of the amazing discoveries since, prominent among them being the tissue repair functions of Tregs, identifying them as immune system regulators not merely suppressor T cells.

Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses ▪ Abstract Naturally occurring CD4+ regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic sel...

I've noted for a long time a desire among many to try & write particular people out of the narrative of the history of Treg research. This review, by the one person everyone agrees is pivotal, provides an accurate assessment for those who don't know the field:

www.annualreviews.org/content/jour...

Séamus Heaney was also uncontactable as he was sailing when he won for literature in '95

I think, Fiona Powrie, Ethan Shevach, Jeff Bluestone, Diane Mathis and Christoph Benoist all would lay claim too. Don Mason is dead, but he probably started his studies in the area at a similar time to Sakaguchi.

All praise to him is well warranted.

It is strange that there hasn't been an award for T cells/B cells, given that there is sufficient consensus that Miller and Cooper could share it.

The mention of Sakaguchi alone was cold, Jeff 😂

Anyone have any expertise/experience with interrogating SNP/InDel in a mouse genome using a reference genome. We have an alignment and are using Integrated Genomics Viewer, but are having trouble figuring some stuff out.

With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.

Gianna Hammer & I are thrilled to co-Chair the 64th @midwinter-immun.bsky.social Conference of Immunologists Jan. 24-27, 2026. Join us & an amazing lineup of speakers including Carla Rothlin as Dan Campbell memorial lecturer for some exciting science in lovely Asilomar, CA!
www.midwconfimmunol.org

Ugh. So many businesses thrive only by amplifying insecurities and making us feel inadequate: Not good enough, not beautiful enough, not clean enough, not rich enough, not thin enough, not popular enough, not tech savvy enough. EFF THAT. Don’t buy what they’re selling. You’re wonderful as you are.

Studying ecoimmunology? 🌍🧬

Submit your work to Discovery Immunology’s new Ecoimmunology Special Collection, exploring how ecological factors shape immune responses in humans & animals.

📢 Editors: Dr Iris Mair & Prof Kathryn Else

🔗 https://bit.ly/4lZX3NM

#Ecoimmunology #Immunology

Does anyone have any recommendations for a company/service that can sequence a mouse genome (B6 background) and provide analysis to a reference genome?

I'm also expecting that the number of submissions from "the elite" will increase as their hit rate drops, and so the effective payline will likely be worse as the competition within a given study section increases.

And what is a reviewer morally obligated to do? Is scoring the way we're meant to a bigger dereliction of duty than driving score compression.

🐭 How does microbial exposure shape mouse model outcomes?

A new Discovery Immunology study compares naturalization methods - co-housing, feralization, or both, and reveals distinct effects on gut immunity and microbiota.

🔗 https://bit.ly/44md5LQ

#Microbiome #Immunology

Centre to study how exposome causes chronic inflammatory disease A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...