Philip Ahern

Studying ecoimmunology? 🌍🧬

Submit your work to Discovery Immunology’s new Ecoimmunology Special Collection, exploring how ecological factors shape immune responses in humans & animals.

📢 Editors: Dr Iris Mair & Prof Kathryn Else

🔗 https://bit.ly/4lZX3NM

#Ecoimmunology #Immunology

Does anyone have any recommendations for a company/service that can sequence a mouse genome (B6 background) and provide analysis to a reference genome?

I'm also expecting that the number of submissions from "the elite" will increase as their hit rate drops, and so the effective payline will likely be worse as the competition within a given study section increases.

And what is a reviewer morally obligated to do? Is scoring the way we're meant to a bigger dereliction of duty than driving score compression.

🐭 How does microbial exposure shape mouse model outcomes?

A new Discovery Immunology study compares naturalization methods - co-housing, feralization, or both, and reveals distinct effects on gut immunity and microbiota.

🔗 https://bit.ly/44md5LQ

#Microbiome #Immunology

Centre to study how exposome causes chronic inflammatory disease A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Writing a paper?

Join us tomorrow at 12:00 BST for a free webinar with OUP Publisher Rachel Moriarty & our very own EIC Simon Milling.

Essential tips on journal selection, peer review, and maximising impact.

Register here: https://bit.ly/44ARC1p

100%. There are so many things need saving, that constituents aren't going to be calling their Senators about NIH, and "I saved NIH" isn't going to buy any points if everything else goes through. Nobody is saving NIH.

The negative impacts of “impact” Recent articles in several scientific journals highlight the troubling upsurge in retractions and data manipulation impacting the integrity of peer-reviewe

Great piece re how to tackle reproducibility/fraud in science. Like many things in life, policing is a blunt tool, we should tackle the underlying causes of these issues.

academic.oup.com/jimmunol/art...

Does anyone have DNA/ear biopsy from SJL (CD45.1) mice from Taconic or Charles River (originating from there, even if they've been in-house for a long time that's fine) that they can share? I don't have much reach here, would appreciate people sharing the post.

New immunological discoveries deserve wide reach.

With read & publish deals, eligible authors can publish open access in Discovery Immunology for free! 🚀

Find out if you’re eligible here: bit.ly/4no9OTy

Lawmakers in Congress should not be buying, trading, and owning individual stocks. Period.

It’s long past time to BAN Congressional stock trading.

📢 Final call! Submissions for the Re-discovering Myeloid Cells Special Collection close end of June 2025.

Share your latest insights into myeloid cell biology, function, and pathology. Don’t miss out!

🔗 https://bit.ly/43OULe9

Somatic hypermutation generates antibody specificities beyond the primary repertoire Initial specificity is thought to be required for somatic hypermutation (SHM)-driven antibody evolution. Zuo, Gautam, et al. demonstrate that non-cognate B cells can enter germinal centers, undergo SH...

I thought this was really interesting. Somatic hypermutation can generate new specificities not present in the germline. Hard to quantify how prevalent such specificities are in the immune repertoire, but it would help prevent holes in the repertoire

www.cell.com/immunity/ful...

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social

www.pnas.org/doi/10.1073/...

Yeah, should be stated as such. Seems pretty ok to me. Not everyone can afford to power an omics study as needed, but still recognise that they can be used to point in the right direction even if not a statistically solid determination of differences in all things measured (heuristic approach).

From bench to bedside, better models mean better arthritis therapies! 💡🧬

Explore this open access guide to standardizing murine arthritis scoring for clearer, comparable results.

Full article: https://bit.ly/4mEgigp

#InflammatoryArthritis #RheumatoidArthritis #AnimalModels #Immunology

Is it unreasonable to say "we did this omics in a statistically sub par way, so only signals where we show follow up data should be considered to be robust"? Seems ok to me. Maybe this would be more powerful if a followup studied a predicted null effect and something considered to be significant?

Discovery Immunology publishes sound science on novel immune mechanisms in humans and animals. We've published some great papers. Publishing here, with the British Society for Immunology @britsocimm.bsky.social also helps support the immunology community

@discovimmunol.bsky.social

⏳ Final call! The Re-discovering Myeloid Cells collection closes for submissions at the end of this month.

Got research on monocytes, macrophages, or other myeloid cells? 🧬 Now’s the time to submit!

📢 Don’t miss out, submit today: https://bit.ly/4kLSs0L

#Immunology #MyeloidCells #Macrophages

📢 Calling all immunology researchers! Submit your ground-breaking discoveries to Discovery Immunology - an Open Access journal by @britsocimm.bsky.social

Fast online publication, expert editorial board, and global visibility await! 🔬🌍

📝 Learn more: https://bit.ly/3TXQOgF

#Immunology

Our open access journal @discovimmunol.bsky.social is waiting for your immunology research and review papers. Submitting to this journal is a great way to get your research out there and to support the immunology community.

Are you working in cellular, molecular or comparative immunology? If yes, do consider the BSI's newest open access journal @discovimmunol.bsky.social

NIH Extends the ESI eligibility window A tiny ray of positive news has sunbeamed through the storm clouds. The NIH has announced (NOT-OD-25-114) that Early Stage Investigators (ESI) who reached the end of their eligibility from the Fall…

NIH Extends the ESI eligibility window drugmonkey.wordpress.com/2025/05/21/n...

Have novel findings in cellular, molecular or comparative immunology?

Discovery Immunology is accepting submissions!

🔍 Original research, reviews, short reports & more

💡 Veterinary studies now welcome

🔗 Call for papers: bit.ly/3WmPhl3

What do rewilding, dirty mice & tidal rhythms have to do with immunity?

"Context matters: Immunology meets ecology" introduces ecoimmunology - a field exploring immune variation in the real world.

A must-read for researchers rethinking immunity 🌱

🔗 bit.ly/3Sg9rvC

Lets introduce #ecoimmunology - a field exploring immune variation in the real world. Take a look @discovimmunol.bsky.social

2/2 Does this sound fine to you as there is no anti-male response possible, or is it heretical? We have not noticed a sex difference in the assay, and would compare conditions where everything was seeded from this one common pool of cells, so all comparisons would be impacted (if at all) equally.

1/2 T cells friends. We are doing some in vitro experiments with a TCR transgenic that's on a RAG-/- background, so there is no endogenous TCR rearrangement. It breeds poorly. What do you think about an experiment where our input cells are a pool from male and female mice together with female BMDC?

Emerging evidence links Gamma Delta (γδ) T cell changes in the uterus to pregnancy disorders like recurrent miscarriage and preterm birth.

Could they be targets for future therapies?

🔍 Full review: bit.ly/44xC6Uu

#Fertility #Immunology #WomensHealth